Browsing by Author "Orekhov, Alexander"
Now showing items 1-5 of 5
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Lipid-lowering therapies for atherosclerosis: Statins, fibrates, ezetimibe and pcsk9 monoclonal antibodies
Ali, A.H.; Younis, Nour; Abdallah, Rola; Shaer, Farah; Dakroub, Ali; Ayoub, Mohammed Akli; Iratni, Rabah; Yassine, Hadi Mohamad; Zibara, Kazem; Orekhov, Alexander; El-Yazbi, Ahmed Fawzy; Eid, Ali H.... more authors ... less authors ( Bentham Science Publishers , 2021 , Article Review)Cardiovascular disease (CVD) remains the primary cause of global morbidity and mortality. CVD includes various life-threatening conditions such as myocardial infarction, stroke and peripheral arterial diseases. In this ... -
Oxidative Stress-Induced Endothelial Dysfunction in Cardiovascular Diseases
Shaito, Abdullah; Aramouni, Karl; Assaf, Roland; Parenti, Astrid; Orekhov, Alexander; El Yazbi, Ahmed; Pintus, Gianfranco; Eid, Ali H.... more authors ... less authors ( IMR Press , 2022 , Article Review)Cardiovascular disease (CVD) is a major cause of mortality worldwide. A better understanding of the mechanisms underlying CVD is key for better management or prevention. Oxidative stress has been strongly implicated in the ... -
Proatherogenic sialidases and desialylated lipoproteins: 35 years of research and current state from bench to bedside
Mezentsev, Alexandre; Bezsonov, Evgeny; Kashirskikh, Dmitry; Baig, Mirza S.; Eid, Ali H.; Orekhov, Alexander... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2021 , Article)This review summarizes the main achievements in basic and clinical research of atheroscle-rosis. Focusing on desialylation as the first and the most important reaction of proatherogenic pathological cascade, we speak of ... -
Role of RhoA and Rho-associated kinase in phenotypic switching of vascular smooth muscle cells: Implications for vascular function
Tedy, Sawma; Shaito, Abdullah; Najm, Nicolas; Sidani, Munir; Orekhov, Alexander; El-Yazbi, Ahmed F.; Iratni, Rabah; Eid, Ali H.... more authors ... less authors ( Elsevier , 2022 , Article Review)Cardiovascular disease (CVD) continues to be the primary cause of global mortality. Vascular smooth muscle cells (VSMCs) are integral components of vascular structure and function, evident by their vital roles in modulating ... -
Visfatin : An emerging adipocytokine bridging the gap in the evolution of cardiovascular diseases
Dakroub, Ali; Nasser, Suzanne A; Kobeissy, Firas; Yassine, Hadi M; Orekhov, Alexander; Sharifi-Rad, Javad; Iratni, Rabah; El-Yazbi, Ahmed F; Eid, Ali H... more authors ... less authors ( Wiley , 2021 , Article)Visfatin/nicotinamide phosphoribosyltransferase (NAMPT) is an adipokine expressed predominately in visceral fat tissues. High circulating levels of visfatin/NAMPT have been implicated in vascular remodeling, vascular ...