تصفح حسب المؤلف "Shirai, Mikiyasu"
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Liraglutide treatment improves the coronary microcirculation in insulin resistant Zucker obese rats on a high salt diet.
Sukumaran, Vijayakumar; Tsuchimochi, Hirotsugu; Sonobe, Takashi; Waddingham, Mark T; Shirai, Mikiyasu; Pearson, James T... more authors ... less authors ( BMC , 2020 , Article)Obesity, hypertension and prediabetes contribute greatly to coronary artery disease, heart failure and vascular events, and are the leading cause of mortality and morbidity in developed societies. Salt sensitivity exacerbates ... -
β-blockade prevents coronary macro- and microvascular dysfunction induced by a high salt diet and insulin resistance in the Goto–Kakizaki rat
Pearson, James T.; Thambyah, Hamish P.; Waddingham, Mark T.; Inagaki, Tadakatsu; Sukumaran, Vijayakumar; Ngo, Jennifer P.; Ow, Connie p.C.; Sonobe, Takashi; Chen, Yi Ching; Edgley, Amanda J.; Fujii, Yutaka; Du, Cheng-Kun; Zhan, Dong-Yun; Umetani, Keiji; Kelly, Darren J.; Tsuchimochi, Hirotsugu; Shirai, Mikiyasu... more authors ... less authors ( Portland Press Ltd , 2021 , Article)A high salt intake exacerbates insulin resistance, evoking hypertension due to systemic perivascular inflammation, oxidative-nitrosative stress and endothelial dysfunction. Angiotensin-converting enzyme inhibitor (ACEi) ...