Browsing by Author "Pasha, Mazhar"
Now showing items 1-5 of 5
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Endoplasmic Reticulum (ER) Stress-Generated Extracellular Vesicles (Microparticles) Self-Perpetuate ER Stress and Mediate Endothelial Cell Dysfunction Independently of Cell Survival.
Osman, Aisha; El-Gamal, Heba; Pasha, Mazhar; Zeidan, Asad; Korashy, Hesham M; Abdelsalam, Shahenda S; Hasan, Maram; Benameur, Tarek; Agouni, Abdelali... more authors ... less authors ( Frontiers Media , 2020 , Article)Circulating extracellular vesicles (EVs) are recognized as biomarkers and effectors of endothelial dysfunction, the initiating step of cardiovascular abnormalities. Among these EVs, microparticles (MPs) are vesicles directly ... -
Metformin Induces Different Responses in Clear Cell Renal Cell Carcinoma Caki Cell Lines.
Pasha, Mazhar; Sivaraman, Siveen K; Frantz, Ronald; Agouni, Abdelali; Munusamy, Shankar ( MDPI , 2019 , Article)Clear cell renal cell carcinoma (ccRCC) is the most common and lethal form of urological cancer diagnosed globally. Mutations of the von Hippel-Lindau tumor-suppressor gene and the resultant overexpression of hypoxia-inducible ... -
Microparticles as Potential Mediators of High Glucose-Induced Renal Cell Injury.
Ravindran, Sreenithya; Pasha, Mazhar; Agouni, Abdelali; Munusamy, Shankar ( MDPI , 2019 , Article)Diabetic nephropathy (DN) is the most common cause of chronic kidney disease worldwide. Activation of signaling pathways such as the mammalian target of rapamycin (mTOR), extracellular signal-regulated kinases (ERK), ... -
Protein tyrosine phosphatase 1B inhibition improves endoplasmic reticulum stress-impaired endothelial cell angiogenic response: A critical role for cell survival
ABDELSALAM, SHAHENDA S.; PASHA, MAZHAR; EL-GAMAL, HEBA; HASAN, MARAM; ELRAYESS, MOHAMED A.; ZEIDAN, ASAD; KORASHY, HESHAM M.; AGOUNI, ABDELALI... more authors ... less authors ( Spandidos publications , 2021 , Article)Endoplasmic reticulum (ER) stress contributes to endothelial dysfunction, which is the initial step in atherogenesis. Blockade of protein tyrosine phosphatase (PTP)1B, a negative regulator of insulin receptors that is ... -
Sestrin2 as a Novel Biomarker and Therapeutic Target for Various Diseases
Pasha, Mazhar; Eid, Ali H.; Eid, Assaad A.; Gorin, Yves; Munusamy, Shankar ( Hindawi , 2017 , Article)Sestrin2 (SESN2), a highly conserved stress-inducible metabolic protein, is known to repress reactive oxygen species (ROS) and provide cytoprotection against various noxious stimuli including genotoxic and oxidative stress, ...