Browsing by Author "n 94093771"
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High-Risk Human Papillomaviruses (HPV) and Epstein - Barr virus (EBV) are Commonly Present in Rectal Cancer
Gupta, Ishita; Jabeen, Ayesha; Skenderi, Faruk; Malki, Mohammed; Al-Thawadi, Hamda; Al Moustafa, Ala‑Eddin; Vranic, Semir... more authors ... less authors ( Springer Nature , 2020 , Conference Paper)Background: Human papillomaviruses (HPVs) and Epstein–Barr virus (EBV) are well-established oncoviruses that can be co-present and cooperate in the initiation and/or progression of various human cancers. We recently reported ... -
High-risk human papillomaviruses and Epstein-Barr virus in breast cancer in Lebanese women and their association with tumor grade: a molecular and tissue microarray study.
Nagi, Karim; Gupta, Ishita; Jurdi, Nawaf; Jabeen, Ayesha; Yasmeen, Amber; Batist, Gerald; Vranic, Semir; Al-Moustafa, Ala-Eddin... more authors ... less authors ( BMC , 2021 , Article)High-risk human papillomaviruses (HPVs) are present and can cooperate with Epstein-Barr virus (EBV) to initiate and/or enhance the progression of several types of human carcinomas including cervical as well as head and ... -
High-risk human papillomaviruses and Epstein–Barr virus in breast cancer in Lebanese women and their association with tumor grade: a molecular and tissue microarray study
Nagi, Karim; Gupta, Ishita; Jurdi, Nawaf; Jabeen, Ayesha; Yasmeen, Amber; Batist, Gerald; Vranic, Semir; Al-Moustafa, Ala Eddin... more authors ... less authors ( Springer Nature , 2021 , Article)Background: High-risk human papillomaviruses (HPVs) are present and can cooperate with Epstein–Barr virus (EBV) to initiate and/or enhance the progression of several types of human carcinomas including cervical as well as ... -
HPV and Recurrent Respiratory Papillomatosis: A Brief Review
Ouda, Amr Mohamed; Elsabagh, Ahmed Adel; Elmakaty, Ibrahim Mohamed; Gupta, Ishita; Vranic, Semir; Al-Thawadi, Hamda; Al Moustafa, Ala-Eddin... more authors ... less authors ( MDPI , 2021 , Article)Recurrent Respiratory Papillomatosis (RRP) is a rare but severe manifestation of human papillomavirus (HPV). As our knowledge about HPV infections has expanded, it has become possible to understand the course of RRP disease ... -
Human Papillomaviruses and Epstein-Barr Virus Interactions in Colorectal Cancer: A Brief Review.
Fernandes, Queenie; Gupta, Ishita; Vranic, Semir; Al Moustafa, Ala-Eddin ( MDPI , 2020 , Article)Human papillomaviruses (HPVs) and the Epstein-Barr virus (EBV) are the most common oncoviruses, contributing to approximately 10%-15% of all malignancies. Oncoproteins of high-risk HPVs (E5 and E6/E7), as well as EBV (LMP1, ... -
Human Papillomaviruses-Related Cancers: An Update on the Presence and Prevention Strategies in the Middle East and North African Regions.
Fernandes, Queenie; Allouch, Soumaya; Gupta, Ishita; Elmakaty, Ibrahim; Elzawawi, Khaled E; Amarah, Ahmed; Al-Thawadi, Hamda; Al-Farsi, Halema; Vranic, Semir; Al Moustafa, Ala-Eddin... more authors ... less authors ( MDPI , 2022 , Article Review)The human papillomavirus (HPV) is a non-enveloped double-stranded DNA virus capable of infecting skin and mucosa epithelial cells. Commonly, HPV infection is associated with sexually transmitted diseases and is considered ... -
Implications of Gut Microbiota in Epithelial–Mesenchymal Transition and Cancer Progression: A Concise Review
Gupta, Ishita; Pedersen, Shona; Vranic, Semir; Al Moustafa, Ala Eddin ( MDPI , 2022 , Article Review)Advancement in the development of molecular sequencing platforms has identified infectious bacteria or viruses that trigger the dysregulation of a set of genes inducing the epithelial– mesenchymal transition (EMT) event. ... -
KYNU, a novel potential target that underpins CD44-promoted breast tumour cell invasion
Al-Mansoob, Maryam; Gupta, Ishita; Stefan Rusyniak, Radoslaw; Ouhtit, Allal ( Blackwell Publishing Inc. , 2021 , Article Review)Using a validated tetracycline-off-inducible CD44 expression system in mouse model, we have previously demonstrated that the hyaluronan (HA) receptor CD44 promotes breast cancer (BC) metastasis to the liver. To unravel the ... -
Molecular Evidence of Anticancer Activity of Camel Milk Combined with Camel Urine
Gupta, Ishita; Shanmuganathan, Sumaya; Al-Abri, Hisham; Ouhtit, Allal ( Austin Publishing Group , 2021 , Article)Camel Milk (CM) and Camel Urine (CU) is a traditional practice in the Middle East and other countries as an alternative treatment against cancer. We hypothesized that a combination of CM and CU (CM+CU), used at ... -
Molecular Mechanisms of Colon Cancer Progression and Metastasis: Recent Insights and Advancements.
malki, ahmed; ElRuz, Rasha; Gupta, I.; Allouch, A; vranic, S; Al moustafa, A E... more authors ... less authors ( MDPI , 2020 , Article Review)Colorectal cancer (CRC), the third most common type of cancer, is the second leading cause of cancer-related mortality rates worldwide. Although modern research was able to shed light on the pathogenesis of CRC and provide ... -
MXene Nanosheets May Induce Toxic Effect on the Early Stage of Embryogenesis.
Alhussain, Hashim; Augustine, Robin; Hussein, Essraa A; Gupta, Ishita; Hasan, Anwarul; Al Moustafa, Ala-Eddin; Elzatahry, Ahmed... more authors ... less authors ( American Scientific Publishers , 2020 , Article)MXene (Ti₃C₂T), as a novel 2D material, has produced a great interest due to its promising properties in biomedical applications, nevertheless, there is a lack of studies dedicated to investigate the possible toxic effect ... -
Naked Poly(amidoamine) Dendrimer Nanoparticles Exhibit Intrinsic Embryotoxicity During the Early Stages of Normal Development.
Kheraldine, Hadeel; Gupta, Ishita; Alhussain, Hashim; Jabeen, Ayesha; Akhtar, Saghir; Al Moustafa, Ala-Eddin; Rachid, Ousama... more authors ... less authors ( American Science Publishers ASP , 2020 , Article)To investigate the impact of poly(amidoamine) dendrimers (PAMAMs) in the embryo, we explored the outcome of different generations (G₄ and G) on the early stages of embryogenesis using the chicken embryo as a model. We also ... -
Oncoproteins of High-Risk HPV and EBV Cooperate to Enhance Cell Motility and Invasion of Human Breast Cancer Cells Erk1/Erk2 and β-Catenin Signaling Pathways.
Gupta, Ishita; Jabeen, Ayesha; Vranic, Semir; Al Moustafa, Ala-Eddin; Al-Thawadi, Hamda ( Frontiers Media , 2021 , Article)Breast cancer is a leading cause of death in women around the world. Most breast cancer-related deaths are a result of complications from the metastatic spread. Several recent studies reported that high-risk human ... -
Presence of high-risk HPVs, EBV, and MMTV in human triple-negative breast cancer.
Gupta, Ishita; Ulamec, Monika; Peric-Balja, Melita; Ramic, Snjezana; Al Moustafa, Ala-Eddin; Vranic, Semir; Al-Farsi, Halema F... more authors ... less authors ( Taylor and Francis , 2021 , Article)Breast cancer, the most frequent disease amongst women worldwide, accounts for the highest cancer-related mortality rate. Triple-negative breast cancer (TNBC) subtype encompasses ~15% of all breast cancers and lack estrogen, ... -
SARS-CoV-2 Infection and Lung Cancer: Potential Therapeutic Modalities.
Gupta, Ishita; Rizeq, Balsam; Elkord, Eyad; Vranic, Semir; Al Moustafa, Ala-Eddin ( MDPI , 2020 , Article Review)Human coronaviruses, especially SARS-CoV-2, are emerging pandemic infectious diseases with high morbidity and mortality in certain group of patients. In general, SARS-CoV-2 causes symptoms ranging from the common cold to ... -
Significant Toxic Effect of Carbon Nanofibers at the Early Stage of Embryogenesis
Abdo, Ghada G.; Kheraldine, Hadeel; Gupta, Ishita; Rizeq, Balsam; Elzatahry, Ahmed; Al Moustafa, Ala-Eddin; Khalil, Ashraf... more authors ... less authors ( NLM (Medline) , 2020 , Article)Implementation of carbon nanofibers (CNFs) in biomedical applications have successful outcomes, however, they are still considered as a potential hazard. We herein used avian embryos at 3 days and its chorioallantoic ... -
Substantial cell apoptosis provoked by naked PAMAM dendrimers in HER2-positive human breast cancer via JNK and ERK1/ERK2 signalling pathways
Hadeel, Kheraldine; Gupta, Ishita; Alhussain, Hashim; Jabeen, Aayesha; Cyprian, Farhan S.; Akhtar, Saghir; Al Moustafa, Ala-Eddin; Rachid, Ousama... more authors ... less authors ( Elsevier , 2021 , Article)HER2-positive breast cancer is one of its most challenging subtypes, forming around 15–25% of the total cases. It is characterized by aggressive behavior and treatment resistance. On the other hand, poly (amidoamine) (PAMAM) ... -
The Combination of Dasatinib and PD L1 inhibitor prevents the progression of epithelial mesenchymal transition and dramatically blocks cell invasion of HER2 positive breast cancer cells
Kheraldine, Hadeel; Gupta, Ishita; Cyprian, Farhan; Vranic, Semir; Al Moustafa, Ala-Eddin ( Qatar University Press , 2021 , Poster)Introduction: Both Dasatinib (DA), a tyrosine kinase inhibitor that is used for targeted cancer therapy, and programmed death-ligand 1 (PD-1/PD-L1) inhibitor that is an immune checkpoint therapy, play a vital role in the ... -
Towards understanding the genetics of Autism
Shailesh, Harshita; Gupta, Ishita; Sif, Said; Ouhtit, Allal ( Frontiers in Bioscience , 2016 , Article Review)Autism spectrum disorder (ASD) includes a group of neurodevelopmental disorders that affect communication skills, social interaction and intellectual ability. Despite evidence suggesting a strong genetic link with ASD, the ... -
Triple Negative Breast Cancer Profile, from Gene to microRNA, in Relation to Ethnicity.
Gupta, Ishita; Sareyeldin, Rasha M.; Al-Hashimi, Israa; Al-Thawadi, Hamda A.; Al Farsi, Halema; Vranic, Semir; Al Moustafa, Ala-Eddin... more authors ... less authors ( MDPI , 2019 , Article)Breast cancer is the most frequent cause of cancer-related deaths among women worldwide. It is classified into four major molecular subtypes. Triple-negative breast cancers (TNBCs), a subgroup of breast cancer, are defined ...