تصفح حسب الموضوع "Cardiomyocytes"
السجلات المعروضة 1 -- 5 من 5
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Anti-hypertrophic effect of Na+/H+ exchanger-1 inhibition is mediated by reduced cathepsin B
( Elsevier , 2020 , Article)Previous studies have established the role of Na+/H+ exchanger isoform-1 (NHE1) and cathepsin B (Cat B) in the development of cardiomyocyte hypertrophy (CH). Both NHE1 and Cat B are activated under acidic conditions ... -
Cathepsin B Induced Cardiomyocyte Hypertrophy Requires Activation of The Na+/H+ Exchanger Isoform-1
(2016 , Master Thesis)Multiple studies have demonstrated that proteases, specifically cathepsin B (Cat B) and matrix metalloproteinase-9 (MMP-9) contribute to the remodeling of the extracellular matrix (ECM), a hallmark of cardiac hypertrophy ... -
Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPSC-CMs) as a Platform for Modeling Arrhythmias
( Springer Nature , 2022 , Book chapter)Cardiac arrhythmias can arise due to a host of both genetic and acquired factors. Specifically, the genetic basis of arrhythmogenesis is not fully understood due to the lack of robust models that reliably recapitulate human ... -
Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPSC-CMs) as a Platform for Modeling Arrhythmias
( Springer Nature , 2022 , Book chapter)Cardiac arrhythmias can arise due to a host of both genetic and acquired factors. Specifically, the genetic basis of arrhythmogenesis is not fully understood due to the lack of robust models that reliably recapitulate human ... -
The march of pluripotent stem cells in cardiovascular regenerative medicine.
( BMC , 2018 , Article Review)Cardiovascular disease (CVD) continues to be the leading cause of global morbidity and mortality. Heart failure remains a major contributor to this mortality. Despite major therapeutic advances over the past decades, a ...