تصفح حسب الموضوع "Ubiquitin"
السجلات المعروضة 1 -- 4 من 4
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Detection of β-Arrestin-Mediated G Protein-Coupled Receptor Ubiquitination Using BRET.
( Humana Press, New York, NY , 2019 , Book chapter)Ubiquitination of G protein-coupled receptors (GPCRs) is an important dynamic posttranslational modification that has been linked to the intracellular trafficking of internalized GPCRs to lysosomes. Ubiquitination of GPCRs ... -
In-frame fusion of SUMO1 enhances βarrestin2's association with activated GPCRs as well as with nuclear pore complexes
( Elsevier , 2020 , Article)Small ubiquitin like modifier (SUMO) conjugation or SUMOylation of βarrestin2 promotes its association with the clathrin adaptor protein AP2 and facilitates rapid β2 adrenergic receptor (β2AR) internalization. However, ... -
TRAF6-mediated ubiquitination of NEMO requires p62/sequestosome-1
( Elsevier Ltd , 2014 , Article)The atypical protein kinase C-interacting protein p62/sequestosome-1 (p62) has emerged as a crucial molecule in a variety of cellular functions due to its involvement in various signaling mechanisms. p62 has been implicated ... -
Ubiquitin-specific peptidase 37: an important cog in the oncogenic machinery of cancerous cells.
( BMC , 2021 , Article Review)Protein ubiquitination is one of the most crucial posttranslational modifications responsible for regulating the stability and activity of proteins involved in homeostatic cellular function. Inconsistencies in the ...