Browsing by Subject "Alzheimer's disease"
Now showing items 1-11 of 11
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An Arabic Version of the cognitive subscale of the Alzheimer's Disease Assessment Scale (ADAS-Cog): Reliability, validity, and normative data
( IOS Press , 2017 , Article)The Alzheimer's Disease Assessment Scale's cognitive subscale (ADAS-Cog) is the most widely used instrument for screening cognitive dysfunction in Alzheimer's disease. The aim of the present study was to develop an Arabic ... -
Body mass index and risk of Parkinson, Alzheimer, Dementia, and Dementia mortality: a systematic review and dose-response meta-analysis of cohort studies among 5 million participants
( Taylor and Francis Ltd. , 2022 , Article Review)Objective: Inconsistent results regarding the association between the Body Mass Index (BMI) and brain disorders have been reported. We performed this study to investigate the association between BMI and risk of Parkinson, ... -
Cognitive Theory of Mind Influences Destination Memory: Evidence from Normal Aging and Alzheimer's Disease
( Oxford University Press , 2019 , Article)Objective: Theory of mind and destination memory are social abilities that require processing the attributes of interlocutors. Empirical research has demonstrated a relationship between performance on both abilities in ... -
Common and Rare Genetic Variants Associated With Alzheimer's Disease
( WILEY PERIODICALS, INC. , 2016 , Article)Alzheimer's disease (AD) is one of the most devastating disorders. Despite the continuing increase of its incidence among aging populations, no effective cure has been developed mainly due to difficulties in early diagnosis ... -
Computational investigation of mechanistic insights of Aβ42 interactions against extracellular domain of nAChRα7 in Alzheimer's disease
( Taylor and Francis Ltd , 2019 , Article)Aim: Amyloid beta (Aβ) 1-42, which is a basic constituent of amyloid plaques, binds with extracellular transmembrane receptor nicotine acetylcholine receptor α7 (nAChRα7) in Alzheimer’s disease. Materials and Methods: ... -
Mechanisms of amyloid proteins aggregation and their inhibition by antibodies, small molecule inhibitors, nano-particles and nano-bodies
( Elsevier , 2021 , Article)Protein misfolding and aggregation can be induced by a wide variety of factors, such as dominant disease-associated mutations, changes in the environmental conditions (pH, temperature, ionic strength, protein concentration, ... -
Recent Perspective About the Amyloid Cascade Hypothesis and Stem Cell-Based Therapy in the Treatment of Alzheimer's Disease
( Bentham Science , 2016 , Book chapter)Alzheimer's disease (AD) is a complex neurodegenerative condition that is clinically characterized by impaired cognitive functions. The major morphologically observed lesion of AD encompasses the accumulation of extracellular ... -
The role of amyloids in Alzheimer's and Parkinson's diseases
( Elsevier , 2021 , Article)With varying clinical symptoms, most neurodegenerative diseases are associated with abnormal loss of neurons. They share the same common pathogenic mechanisms involving misfolding and aggregation, and these visible aggregates ... -
Shotgun-based proteomics of extracellular vesicles in Alzheimer’s disease reveals biomarkers involved in immunological and coagulation pathways
( Nature Research , 2021 , Article)Alzheimer’s disease (AD) is the most common form of dementia and without readily available clinical biomarkers. Blood-derived proteins are routinely used for diagnostics; however, comprehensive plasma profiling is challenging ... -
Smell your memories: Positive effect of odor exposure on recent and remote autobiographical memories in Alzheimer's disease
( Routledge , 2019 , Article)Introduction: There is a burgeoning interest in the effects of odor exposure on autobiographical memory in Alzheimer’s disease (AD). We pursued this line of research by assessing the effect of odor exposure on the retrieval ... -
Verum- versus Sham-Acupuncture on Alzheimer’s Disease (AD) in Animal Models: A Preclinical Systematic Review and Meta-Analysis
( hindawi , 2020 , Article)Background. Alzheimer’s disease (AD) is a common health condition affecting senile people and leads to severe cognitive dysfunctions. Acupuncture has been shown to be a possible alternative natural remedy for AD in some ...