Browsing by Subject "CpG islands"
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Characterization of regulatory sequences in alternative promoters of hypermethylated genes associated with tumor resistance to cisplatin
( Spandidos Publications , 2014 , Article)The development of cisplatin resistance in human cancers is controlled by multiple genes and leads to therapeutic failure. Hypermethylation of specific gene promoters is a key event in clinical resistance to cisplatin. ...