Browsing by Author "Bhat, Ajaz"
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The tumor microenvironment as driver of stemness and therapeutic resistance in breast cancer: New challenges and therapeutic opportunities
Mehraj, Umar; Ganai, Rais A.; Macha, Muzafar A.; Hamid, Abid; Zargar, Mohammed A.; Bhat, Ajaz A.; Nasser, Mohd Wasim; Haris, Mohammad; Batra, Surinder K.; Alshehri, Bader; Al-Baradie, Raid Saleem; Mir, Manzoor A.; Wani, Nissar Ahmad... more authors ... less authors ( Springer , 2021 , Article Review)Background: Breast cancer (BC), the second most common cause of cancer-related deaths, remains a significant threat to the health and wellness of women worldwide. The tumor microenvironment (TME), comprising cellular ... -
Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy.
Bhat, Ajaz A; Yousuf, Parvaiz; Wani, Nissar A; Rizwan, Arshi; Chauhan, Shyam S; Siddiqi, Mushtaq A; Bedognetti, Davide; El-Rifai, Wael; Frenneaux, Michael P; Batra, Surinder K; Haris, Mohammad; Macha, Muzafar A... more authors ... less authors ( Springer Nature , 2021 , Article Review)Head and neck squamous cell carcinoma (HNSCC) is a very aggressive disease with a poor prognosis for advanced-stage tumors. Recent clinical, genomic, and cellular studies have revealed the highly heterogeneous and ... -
Ubiquitin-specific peptidase 37: an important cog in the oncogenic machinery of cancerous cells.
Chauhan, Ravi; Bhat, Ajaz A; Masoodi, Tariq; Bagga, Puneet; Reddy, Ravinder; Gupta, Ashna; Sheikh, Zahoor Ahmad; Macha, Muzafar A; Haris, Mohammad; Singh, Mayank... more authors ... less authors ( BMC , 2021 , Article Review)Protein ubiquitination is one of the most crucial posttranslational modifications responsible for regulating the stability and activity of proteins involved in homeostatic cellular function. Inconsistencies in the ...