Browsing by Subject "bioinformatics"
Now showing items 1-11 of 11
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2019-05 - Issue 11 - English Version
( Qatar University , 2019 , Periodical) -
Characterization of regulatory sequences in alternative promoters of hypermethylated genes associated with tumor resistance to cisplatin
( Spandidos Publications , 2014 , Article)The development of cisplatin resistance in human cancers is controlled by multiple genes and leads to therapeutic failure. Hypermethylation of specific gene promoters is a key event in clinical resistance to cisplatin. ... -
Cyclin dependent kinase inhibitor 3 (CDKN3) upregulation is associated with unfavorable prognosis in clear cell renal cell carcinoma and shapes tumor immune microenvironment: A bioinformatics analysis
( Lippincott Williams and Wilkins , 2023 , Article)Cell cycle regulatory proteins plays a pivotal role in the development and progression of many human malignancies. Identification of their biological functions as well as their prognostic utility presents an active field ... -
Different molecular pathways are disrupted in Pyoderma gangrenosum patients and are associated with the severity of the disease.
( Nature Research , 2023 , Article)Pyoderma gangrenosum (PG) is a rare inflammatory skin disease classified within the spectrum of neutrophilic dermatoses. The pathophysiology of PG is yet incompletely understood but a prominent role of genetics facilitating ... -
Genomic and Bioinformatics Approaches for Analysis of Genes Associated With Cancer Risks Following Exposure to Tobacco Smoking
( Frontiers Media S.A. , 2018 , Article Review)Cancer is a significant health problem in the Middle East and global population. It is well established that there is a direct link between tobacco smoking and cancer, which will continue to pose a significant threat to ... -
Molecular analysis of inflammatory diseases.
( Wiley , 2022 , Article Review)If we try to describe the search for molecular actors involved in inflammatory diseases, the picture best representing this task is a mission to unexplored worlds. However, researchers nowadays have powerful tools to support ... -
Novel Comprehensive Bioinformatics Approaches to Determine the Molecular Genetic Susceptibility Profile of Moderate and Severe Asthma.
( MDPI , 2020 , Article)Asthma is a chronic inflammatory condition linked to hyperresponsiveness in the airways. There is currently no cure available for asthma, and therapy choices are limited. Asthma is the result of the interplay between genes ... -
Plant Antimicrobial Peptides as Potential Tool for Topic Treatment of Hidradenitis Suppurativa
( Frontiers Media , 2021 , Article)Among chronic skin autoinflammatory diseases, Hidradenitis Suppurativa (HS) stands out for its chronicity, highly variable condition, and profound impact on the patients’ quality of life. HS is characterized by suppurative ... -
The effect of aging on the bone healing properties of blood plasma
( Elsevier Ltd , 2021 , Article)Objectives: Age-related changes in blood composition have been found to affect overall health. Thus, this study aimed to understand the effect of these changes on bone healing by assessing how plasma derived from young and ... -
The similarity-aware relational intersect database operator
( Springer International Publishing , 2014 , Conference Paper)Identifying similarities in large datasets is an essential operation in many applications such as bioinformatics, pattern recognition, and data integration. To make the underlying database system similarity-aware, the core ... -
Vulnerabilities of the SARS-CoV-2 Virus to Proteotoxicity—Opportunity for Repurposed Chemotherapy of COVID-19 Infection
( Frontiers Media , 2020 , Article)The global pandemic of COVID-19 disease caused by infection with the SARS-CoV-2 coronavirus, has produced an urgent requirement and search for improved treatments while effective vaccines are developed. A strategy for ...