Browsing by Subject "p21"
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Antitumor Activities of the Novel Isosteviol Derivative 10C Against Liver Cancer
( International Institute of Anticancer Research , 2017 , Article)Background/Aim. Hepatocellular carcinoma (HCC) is the most common type of liver cancer and the fifth most common primary malignancy with worldwide increasing incidence. The current study aims to investigate the anticancer ... -
Salinomycin induces apoptosis and senescence in breast cancer: Upregulation of p21, downregulation of survivin and histone H3 and H4 hyperacetylation
( Elsevier , 2013 , Article)Background In the present study, we investigated the effect of Salinomycin on the survival of three human breast cancer cell lines MCF-7, T47D and MDA-MB-231 grown in adherent culture conditions. Methods Cell viability ... -
SKP2 E3 ligase in urological malignancies: a critical regulator of the cell cycle and therapeutic target
( Taylor and Francis Ltd. , 2025 , Article Review)SKP2, an E3 ubiquitin ligase component of the SCF complex, plays a critical role in cell cycle regulation by targeting key inhibitors like p27, p21, and p57 for degradation, thereby promoting G1-S transition. Its overexpression ...