Browsing by Subject "Adipogenesis"
Now showing items 1-7 of 7
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Comparing Methods for Induction of Insulin Resistance in Mouse 3T3-L1 Cells.
( Bentham Science Publishers , 2024 , Article)Cell culture plays a crucial role in addressing fundamental research questions, particularly in studying insulin resistance (IR) mechanisms. Multiple in vitro models are utilized for this purpose, but their technical ... -
Conjugated Linoleic Acid (CLA) co-treatment alleviates antidiabetic drug, rosiglitazone associated deterioration of bone remodeling
( Qatar University Press , 2021 , Poster)Diabetes mellitus (DM) is a chronic metabolic disease characterized by hyperglycemia due to decreased insulin secretion, defective action or both. The rosiglitazone (RSG) is one of the oral antidiabetic drug used in type ... -
GATA-3 as a potential therapeutic target for insulin resistance and type 2 diabetes mellitus.
( PubMed Central , 2020 , Article Review)Impaired adipogenesis plays an important role in the development of obesity-associated insulin resistance and type 2 diabetes as it leads to ectopic fat deposition. The anti-adipogenic transcription factor GATA-3 was ... -
Promoter–enhancer looping at the PPARγ2 locus during adipogenic differentiation requires the Prmt5 methyltransferase
( Oxford University Press , 2016 , Article)PPARγ2 is a critical lineage-determining transcription factor that is essential for adipogenic differentiation. Here we report characterization of the three-dimensional structure of the PPARγ2 locus after the onset of ... -
The Regulation of BRN3B in Adipocytes by Glucose and Insulin
(2014 , Master Thesis)Obesity is the inappropriate accumulation of excess fat stored in the adipocytes of the adipose tissue. Understanding the molecular mechanisms that regulate the process of the preadipocyte to adipocyte conversion, adipogenesis, ... -
Suppression of GATA-3 increases adipogenesis, reduces inflammation and improves insulin sensitivity in 3T3L-1 preadipocytes
( Elsevier , 2020 , Article)© 2020 Impaired adipogenesis plays an important role in the development of obesity-associated insulin resistance and type 2 diabetes. Adipose tissue inflammation is a crucial mediator of this process. GATA-3 plays important ... -
The Role of GATA3 in Adipogenesis & Insulin Resistance
( Qatar University Press , 2020 , Poster)Background: Impaired adipogenesis plays an important role in the development of obesity-associated insulin resistance and type 2 diabetes. Adipose tissue inflammation is a crucial mediator of this process. In hyperglycemia, ...