Browsing by Subject "Apoptosis"
Now showing items 1-20 of 44
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AMP-activated protein kinase as a drug target in chronic kidney disease
( Bentham Science Publishers B.V. , 2018 , Article Review)Background: Chronic kidney disease (CKD) is a condition increasingly affecting millions of individuals worldwide and is ranked as the ninth leading cause of death in the United States. AMP-activated protein kinase (AMPK) ... -
An updated overview of cyanidins for chemoprevention and cancer therapy
( Elsevier , 2023 , Article Review)Anthocyanins are colored polyphenolic compounds that belong to the flavonoids family and are largely present in many vegetables and fruits. They have been used in traditional medicine in many cultures for a long time. The ... -
Anticancer activity of Neosetophomone B by targeting AKT/SKP2/MTH1 axis in leukemic cells
( Elsevier , 2022 , Article)Neosetophomone B (NSP–B), a meroterpenoid fungal secondary metabolite, was investigated for its anticancer potential in leukemic cell lines (K562 and U937). NSP-B treatment of leukemic cells suppressed cell viability by ... -
Anticancer activity of Neosetophomone B, A Fungal Secondary Metabolite, against Hematological Malignancies
( Qatar University Press , 2021 , Poster)Cancer is one of the most life threatening diseases, causing nearly 13% death in the worldwide. Leukemia, cancer of the hematopoetic cells is the main cause of cancer death in adults and children. Therapeutic agents used ... -
Beta-caryophyllene exhibits anti-proliferative effects through apoptosis induction and cell cycle modulation in multiple myeloma cells
( Multidisciplinary Digital Publishing Institute (MDPI) , 2021 , Article)Cannabinoid receptors, which are widely distributed in the body, have been considered as possible pharmacological targets for the management of several tumors. Cannabinoid type 2 receptors (CB2Rs) belong to the G protein-coupled ... -
Carnosol induces ROS-mediated beclin1-independent autophagy and apoptosis in triple negative breast cancer
( Public Library of Science , 2014 , Article)Background: In this study we investigated the in vitro and in vivo anticancer effect of carnosol, a naturally occurring polyphenol, in triple negative breast cancer.Results: We found that carnosol significantly inhibited ... -
Chemokine-cytokine networks in the head and neck tumor microenvironment
( MDPI , 2021 , Article Review)Head and neck squamous cell carcinomas (HNSCCs) are aggressive diseases with a dismal patient prognosis. Despite significant advances in treatment modalities, the five-year survival rate in patients with HNSCC has improved ... -
Cisplatin based therapy: The role of the mitogen activated protein kinase signaling pathway
( BioMed Central Ltd. , 2018 , Article Review)Cisplatin is a widely used chemotherapeutic agent for treatment of various cancers. However, treatment with cisplatin is associated with drug resistance and several adverse side effects such as nephrotoxicity, reduced ... -
Comparative study of the effect of oleuropein and hydroxytyrosol rich extracts on the reproductive toxicity induced by bisphenol A in male rats: biochemical, histopathological, and molecular analyses
( Springer , 2023 , Article)Bisphenol A, or BPA, goes into the composition of a large number of products including sunglasses, infant’s feeding bottles, receipts, or food packaging. Nowadays, there is a growing evidence that BPA may be at the origin ... -
A comprehensive review on the anti-cancer properties and mechanisms of action of sesamin, a lignan in sesame seeds (Sesamum indicum).
( Elsevier , 2017 , Article)Sesamin is the major active ingredient is Sesamum indicum seeds. Several studies revealed that sesamin possesses potent anti-cancer properties. The anti-cancer effects of sesamin have been mainly attributed to its ... -
Correction to: Beta-Caryophyllene Exhibits Anti-Proliferative Effects through Apoptosis Induction and Cell Cycle Modulation in Multiple Myeloma Cells (Cancers, (2021), 13, 22, (5741), 10.3390/cancers13225741)
( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Other)In the original publication [1], errors were identified in the published Figures 4 and 7. The original raw data of western blots could not be retrieved and therefore the experiments were redone to generate the corrected ... -
Correction to: Lead nitrate induces inflammation and apoptosis in rat lungs through the activation of NF‑κB and AhR signaling pathways (Environmental Science and Pollution Research, (2022), 29, 43, (64959-64970), 10.1007/s11356-022-19980-8)
( Springer , 2022 , Article)The sizing of images Figs. 3 and 4 is modified in the original published proof. The Original article has been corrected. -
Curcumin-mediated degradation of S-phase kinase protein 2 induces cytotoxic effects in human papillomavirus-positive and negative squamous carcinoma cells
( Frontiers Media S.A. , 2018 , Article)S-phase kinase-associated protein2 (Skp2), a proto-oncoprotein, plays an important role in development and progression of human malignancies. Skp2 is frequently overexpressed in many human malignancies. It targets cell ... -
The Cytotoxicity Of “Al-Siddir” Tree “Ziziphus Spina Christi” Methanolic Leaves Extract on Her-2 Positive Breast Cancer
(2024 , Master Thesis)HER-2 positive is a subtype of breast cancer that acquires poor prognosis and low survival rates. Targeted therapy is one of the main approaches that are used for the treatment of HER-2-positive breast cancer. However, it ... -
Deregulation of cell growth and apoptosis in UV-induced melanomagenesis
( Frontiers in Bioscience , 2020 , Article Review)We have previously characterized the role of p16/Rb in coordinating the early events in UVB-irradiated skin. As an extension to this work, normal melanocytes and mutant p16-inducible melanoma cell models were employed to ... -
The effect of surface-modified gold nanorods on the early stage of embryonic development and angiogenesis: Insight into the molecular pathways
( MDPI , 2021 , Article)Gold nanorods have been implicated in several biomedical applications. Herein, the effect of two surface-modified gold nanorods on the early stages of embryogenesis and angiogenesis was investigated using avian embryos at ... -
Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis.
( Springer , 2020 , Article Review)Idiopathic pulmonary fibrosis (IPF), the most common form of idiopathic interstitial pneumonia, is a progressive, irreversible, and typically lethal disease characterized by an abnormal fibrotic response involving vast ... -
Greensporone A, a fungal secondary metabolite suppressed constitutively activated AKT via ROS generation and induced apoptosis in leukemic cell lines
( MDPI AG , 2019 , Article)Greensporone A is a fungal secondary metabolite that has exhibited potential in vitro for anti-proliferative activity in vitro. We studied the anticancer activity of greensporone A in a panel of leukemic cell lines. ... -
Greensporone C, a Freshwater Fungal Secondary Metabolite Induces Mitochondrial-Mediated Apoptotic Cell Death in Leukemic Cell Lines
( Frontiers Media S.A. , 2018 , Article)Therapeutic agents used in the treatment of cancer are known to develop resistance against cancer cells. Hence, there is a continuing need to investigate novel agents for the treatment and management of cancer. Antitumor ... -
In vitro evaluation of Neosetophomone B inducing apoptosis in cutaneous T cell lymphoma by targeting the FOXM1 signaling pathway
( Elsevier , 2023 , Article)Background: Cutaneous T cell lymphoma (CTCL) is a T cell-derived non-Hodgkin lymphoma primarily affecting the skin, with treatment posing a significant challenge and low survival rates. Objective: In this study, we ...