Present day inbreeding does not forbid the forensic utility of commonly explored STR loci: A case study of native Qataris

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Author Al-Obaidli, Aisha en_US
Author Sabbagh, Audrey en_US
Author Pravin, Sahaya en_US
Author Krishnamoorthy, Rajagopol en_US
Available date 2009-12-29T07:09:14Z en_US
Publication Date 2008-12-20 en_US
Citation Al-Obaidli, A., Sabbagh, A., Pravin, S., & Krishnamoorthy, R. (2009). Present day inbreeding does not forbid the forensic utility of commonly explored STR loci: A case study of native Qataris. Forensic Science International: Genetics, 4(1), e11–e13 en_US
URI http://dx.doi.org/10.1016/j.fsigen.2008.12.005 en_US
URI http://hdl.handle.net/10576/10555 en_US
Abstract Allele frequency distribution of 15 short tandem repeat (STR) loci (D8S1179, D21S11, D7S820, CSF1PO, D3S1358, TH01, D13S317, D16S539, D2S1338, D19S433, vWA, TPOX, D18S51, D5S818, and FGA) was studied in a sample of 120 unrelated native Qatari population using the AmpFISTR® Identifiler kit (Applied Biosystems, Foster city, CA, USA). All loci met Hardy-Weinberg expectations and there was no evidence for linkage disequilibrium between any of the marker pairs. The most discriminating locus was D2S1338 with a power of discrimination (PD) of 0.969, while the lowest one was TPOX, yet with a PD of 0.821. For all the 15 loci, the combined PD and the combined power of exclusion (PE) were respectively 0.99999999 and 0.99999744. Thus the probability of finding two individuals bearing an identical 15 locus DNA profile is one in 108 native Qatari subjects and this surpasses largely the present day Qatari natives consisting of around 3.5 × 105 individuals. The results of this study demonstrate the usefulness and reliability of the AmpFISTR® Identifiler kit for individual identification in forensic studies in the native Qatari population, despite the current practice of high inbreeding. en_US
Language en en_US
Publisher Elsevier Ireland Ltd. en_US
Subject Forensic en_US
Subject Inbreeding en_US
Subject Population en_US
Subject Qatar en_US
Subject STR en_US
Title Present day inbreeding does not forbid the forensic utility of commonly explored STR loci: A case study of native Qataris en_US
Type Article en_US


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