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    Acquisition of invasiveness by breast adenocarcinoma cells engages established hallmarks and novel regulatory mechanisms

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    Date
    2019
    Author
    Mousa, Hanaa
    Elgamal, Mahmoud
    Marei, Reham Ghazal
    Souchelnytskyi, Nazariy
    Lin, Kah-Wan.
    Souchelnytskyi, Serhiy
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    Abstract
    Background/Aim: Proteomics of invasiveness opens a window on the complexity of the metastasis-engaged mechanisms. The extend and types of this complexity require elucidation. Materials and Methods: Proteomics, immuno -histochemistry, immunoblotting, network analysis and systems cancer biology were used to analyse acquisition of invasiveness by human breast adenocarcinoma cells. Results: We report here that invasiveness network highlighted the involvement of hallmarks such as cell proliferation, migration, cell death, genome stability, immune system regulation and metabolism. Identified involvement of cell-virus interaction and gene silencing are potentially novel cancer mechanisms. Identified 6,113 nodes with 11,055 edges affecting 1,085 biological processes show extensive re-arrangements in cell physiology. These high numbers are in line with a similar broadness of networks built with diagnostic signatures approved for clinical use. Conclusion: Our data emphasize a broad systemic regulation of invasiveness, and describe the network of this regulation. - 2019 International Institute of Anticancer Research. All rights reserved.
    DOI/handle
    http://dx.doi.org/10.21873/CGP.20153
    http://hdl.handle.net/10576/15576
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    • Medicine Research [‎1819‎ items ]

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