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A population study of clinically actionable genetic variation affecting drug response from the Middle East
(
Nature Research
, 2022 , Article)
Clinical implementation of pharmacogenomics will help in personalizing drug prescriptions and alleviate the personal and financial burden due to inefficacy and adverse reactions to drugs. However, such implementation is ...
The QChip1 knowledgebase and microarray for precision medicine in Qatar
(
Nature Research
, 2022 , Article)
Risk genes for Mendelian (single-gene) disorders (SGDs) are consistent across populations, but pathogenic risk variants that cause SGDs are typically population-private. The goal was to develop "QChip1," an inexpensive ...
Qatar Biobank Cohort Study: Study Design and First Results.
(
Oxford University Press (OUP)
, 2019 , Article)
The authors describe the design, implementation and results of Qatar Biobank (QBB) for the first 10,000 participants. QBB is a prospective population-based cohort study in Qatar, established in 2012. QBB's primary goal was ...
Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes
(
Nature Research
, 2021 , Article)
Arab populations are largely understudied, notably their genetic structure and history. Here we present an in-depth analysis of 6,218 whole genomes from Qatar, revealing extensive diversity as well as genetic ancestries ...
The Qatar Biobank: background and methods
(
BioMed Central
, 2015 , Article)
Background: The Qatar Biobank aims to collect extensive lifestyle, clinical, and biological information from up to
60,000 men and women Qatari nationals and long-term residents (individuals living in the country for ≥15 ...
Correlations between Resting Electrocardiogram Findings and Disease Profiles: Insights from the Qatar Biobank Cohort
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2024 , Article)
Background: Resting electrocardiogram (ECG) is a valuable non-invasive diagnostic tool used in clinical medicine to assess the electrical activity of the heart while the patient is resting. Abnormalities in ECG may be ...
Genetic Susceptibility to Arrhythmia Phenotypes in a Middle Eastern Cohort of 14,259 Whole-Genome Sequenced Individuals
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2024 , Article)
Background: The current study explores the genetic underpinnings of cardiac arrhythmia phenotypes within Middle Eastern populations, which are under-represented in genomic medicine research. Methods: Whole-genome sequencing ...
Whole genome sequencing in the Middle Eastern Qatari population identifies genetic associations with 45 clinically relevant traits
(
Springer Nature
, 2021 , Article)
Clinical laboratory tests play a pivotal role in medical decision making, but little is known about their genetic variability between populations. We report a genome-wide association study with 45 clinically relevant traits ...
Actionable genomic variants in 6045 participants from the Qatar Genome Program
(2021 , Article)
In a clinical setting, DNA sequencing can uncover findings unrelated to the purpose of genetic evaluation. The American College of Medical Genetics and Genomics (ACMG) recommends the evaluation and reporting of 59 genes ...