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Mendelian inheritance of trimodal CpG methylation sites suggests distal cis-acting genetic effects.
(
BioMed Central
, 2016 , Article)
Environmentally influenced phenotypes, such as obesity and insulin resistance, can be transmitted over multiple generations. Epigenetic modifications, such as methylation of DNA cytosine-guanine (CpG) pairs, may be carriers ...
PopPAnTe: population and pedigree association testing for quantitative data.
(
BioMed Central
, 2017 , Article)
Family-based designs, from twin studies to isolated populations with their complex genealogical data, are a valuable resource for genetic studies of heritable molecular biomarkers. Existing software for family-based studies ...