Browsing Medicine Research by Title
Now showing items 1125-1144 of 1321
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Signaling diversity of mu- and delta- opioid receptor ligands: Re-evaluating the benefits of β-arrestin/G protein signaling bias.
( Elsevier , 2020 , Article)Opioid analgesics are elective for treating moderate to severe pain but their use is restricted by severe side effects. Signaling bias has been proposed as a viable means for improving this situation. To exploit this ... -
Signaling pathways activated by PACAP in MCF-7 breast cancer cells
( Elsevier Inc. , 2018 , Article)PACAP has opposing roles ranging from activation to inhibition of tumor growth and PACAP agonists/antagonists could be used in tumor therapy. In this study, the effect of PACAP stimulation on signaling pathways was ... -
Signatures of co-deregulated genes and their transcriptional regulators in colorectal cancer.
( Nature Research , 2020 , Article)The deregulated genes in colorectal cancer (CRC) vary significantly across different studies. Thus, a systems biology approach is needed to identify the co-deregulated genes (co-DEGs), explore their molecular networks, and ... -
Silencing of Growth Differentiation Factor-15 Promotes Breast Cancer Cell Invasion by Down-regulating Focal Adhesion Genes.
( International Institute of Anticancer Research , 2020 , Article)As metastasis accounts for most breast cancer (BC)-related deaths, identifying key players becomes research priority. Growth differentiation factor-15 (GDF15), a member of the transforming growth factor-β superfamily, is ... -
Sleep problems in adolescence and overweight/obesity in young adults: is there a causal link?
( Elsevier , 2018 , Article)This study aims to explore if there is a causal association between adolescence sleep problems and overweight/obesity (Ow/Ob) in young adults. Youth self-reports were used to explore if adolescence (mean age 13.90 years, ... -
Sleep quality and obesity in young subjects: a meta-analysis
( Wiley , 2016 , Article)To assess the effect of poor sleep quality on Overweight/Obesity (Ow/Ob) in young subjects, and explore if this association is independent of sleep duration. Pubmed, EMBASE, and MEDLINE databases were searched for papers ... -
Small Cell Lung Carcinoma: Current Diagnosis, Biomarkers, and Treatment Options with Future Perspectives
( MDPI , 2023 , Article Review)Small cell lung cancer (SCLC) is an aggressive malignancy characterized by rapid proliferation, early dissemination, acquired therapy resistance, and poor prognosis. Early diagnosis of SCLC is crucial since most patients ... -
Snornas and mirnas networks underlying covid-19 disease severity
( MDPI , 2021 , Article)There is a lack of predictive markers for early and rapid identification of disease progression in COVID-19 patients. Our study aims at identifying microRNAs (miRNAs)/small nucleolar RNAs (snoRNAs) as potential biomarkers ... -
Soccer-related severe blunt splenic injury in a young goalkeeper
( Elsevier , 2021 , Article)Abdominal injuries are rare in sports, but even minor traumas may result in potentially life-threatening injuries. The most frequent abdominal injury is abdominal wall contusion, following by blunt injuries of the kidneys ... -
Social determinants of depression among mid-to-older aged Australians: A prospective study of the effects of neighbourhood disadvantage and crime
( Elsevier , 2022 , Article)BackgroundFew studies examining social determinants of depression have incorporated area level objectively measured crime combined with self-report measures of perceived crime. How these factors may interrelate with ... -
The social media Infodemic of health-related misinformation and technical solutions
( Elsevier , 2024 , Article)This paper discusses the role of social media algorithms in the spread of misinformation during the COVID-19 pandemic. It aims to propose solutions to combat misinformation and promote accurate, evidence-based public health ... -
Sociocultural insights on dementia care-giving in Arab and Muslim communities: The perspectives of family care-givers
( Cambridge University Press , 2022 , Article)Little is known about the experiences of informal family care-giving for persons with ADRD in the context of Arab and Muslim communities. This paper offers fresh insight into the less-studied private sphere of the home, ... -
SOD2, a Potential Transcriptional Target Underpinning CD44-Promoted Breast Cancer Progression
( MDPI , 2022 , Article Review)CD44, a cell-adhesion molecule has a dual role in tumor growth and progression; it acts as a tumor suppressor as well as a tumor promoter. In our previous work, we developed a tetracycline-off regulated expression of CD44’s ... -
Solely abluminal drug release from coronary stents could possibly improve reendothelialization
( John Wiley and Sons Inc. , 2016 , Article)Objectives To compare a new stent with an asymmetric coating, eluting the drug to the abluminal surface, to a stent with a conventional coating eluting the drug both to the luminal and the abluminal side. Background Stents ... -
Somatostatin receptor SSTR2A and SSTR5 expression in neuroendocrine breast cancer.
( Elsevier , 2019 , Article)Neuroendocrine breast cancer (NEBC) is a group of rare tumors, which could benefit from therapy targeting the somatostatin receptors (SSTRs). In particular, SSTR2A and SSTR5 are potential targets given their consistent ... -
Sorting Out the Myths from the Facts: Commentary on Yasemen Adali et al. (2018) article " The Relationship Between Histopathologic Findings and Body Mass Index in Sleeve Gastrectomy Materials "
( Springer New York LLC , 2019 , Article)[No abstract available] -
Specific gene patterns and molecular pathways related to human carcinogenesis in different populations among various geographic locations.
( Wiley , 2016 , Other)We read with great interest the article by Beg et al,1 which was recently published in Cancer. Colorectal cancers (CRCs) are the most commonly diagnosed malignancies, accounting for approximately 1.36 million new cases ... -
The Spectrum of Mutations of Homocystinuria in the MENA Region
( MDPI , 2020 , Article Review)Homocystinuria is an inborn error of metabolism due to the deficiency in cystathionine beta-synthase (CBS) enzyme activity. It leads to the elevation of both homocysteine and methionine levels in the blood and urine. ... -
SPERM FACTORS AND EGG ACTIVATION The structure and function relationship of sperm PLCZ1
( BioScientifica , 2022 , Article Review)In 2002, sperm-specific phospholipase C zeta1 (PLCZ1) was discovered and through these 20 years, it has been established as the predominant sperm oocyte-activating factor. PLCZ1 cRNA expression or direct protein microinjection ... -
Spindle cell carcinoma of the breast: Rare cancer with potentially targetable biomarkers.
( Elsevier , 2019 , Conference Paper)Background Spindle cell carcinoma is a rare, metaplastic breast cancer (<1% of all breast carcinomas), with reportedly triple-negative (TNBC: ER-/PR-/Her2-) phenotype, associated with a marked resistance to conventional ...