تصفح Biological & Environmental Sciences حسب المؤلف "Eid, Ali H."
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Anti-atherosclerotic plants which modulate the phenotype of vascular smooth muscle cells
Al-Shehabi, Tuqa Saleh; Iratni, Rabah; Eid, Ali H. ( Elsevier , 2016 , Article)Background: Cardiovascular disease (CVD) remains the leading cause of global death, with atherosclerosis being a major contributor to this mortality. Several mechanisms are implicated in the pathogenesis of this disease. ... -
Anti-atherosclerotic plants which modulate the phenotype of vascular smooth muscle cells
Saleh Al-Shehabi, Tuqa; Iratni, Rabah; Eid, Ali H. ( Elsevier , 2016 , Article)Background: Cardiovascular disease (CVD) remains the leading cause of global death, with atherosclerosis being a major contributor to this mortality. Several mechanisms are implicated in the pathogenesis of this disease. ... -
Anti-hypertensive Herbs and their Mechanisms of Action: Part I
Al Disi, Sara S.; Anwar, M. Akhtar; Eid, Ali H. ( Frontiers Media , 2016 , Article)The use of herbal therapies for treatment and management of cardiovascular diseases (CVDs) is increasing. Plants contain a bounty of phytochemicals that have proven to be protective by reducing the risk of various ailments ... -
Anti-Hypertensive Herbs and Their Mechanisms of Action: Part II
Anwar, M. Akhtar; Al Disi, Sara S.; Eid, Ali H. ( Frontiers Media , 2016 , Article)Traditional medicine has a history extending back to thousands of years, and during the intervening time, man has identified the healing properties of a very broad range of plants. Globally, the use of herbal therapies to ... -
Antibody-dependent enhancement (ADE) of SARS-CoV-2 in patients exposed to MERS-CoV and SARS-CoV-2 antigens
Thomas, Swapna; Smatti, Maria K.; Alsulaiti, Haya; Zedan, Hadeel T.; Eid, Ali H.; Hssain, Ali A.; Abu Raddad, Laith J.; Gentilcore, Giusy; Ouhtit, Allal; Althani, Asmaa A.; Nasrallah, Gheyath K.; Grivel, Jean Charles; Yassine, Hadi M.... more authors ... less authors ( Wiley , 2024 , Article)This study evaluated the potential for antibody-dependent enhancement (ADE) in serum samples from patients exposed to Middle East respiratory syndrome coronavirus (MERS-CoV). Furthermore, we evaluated the effect of severe ... -
Burden and disease pathogenesis of influenza and other respiratory viruses in diabetic patients
Swapna, Thomas; Ouhtit, Allal; Al Khatib, Hebah A.; Eid, Ali H.; Mathew, Shilu; Nasrallah, Gheyath K.; Emara, Mohamed M.; Al Maslamani, Muna A.; Yassine, Hadi M.... more authors ... less authors ( Elsevier , 2022 , Article Review)Over the past two decades, diabetes mellitus (DM) has been receiving increasing attention among autoimmune diseases. The prevalence of type 1 and type 2 diabetes has increased rapidly and has become one of the leading ... -
CAMP induces adhesion of microvascular smooth muscle cells to fibronectin via an epac-mediated but PKA-independent mechanism
Eid, Ali H. ( Cell Physiol Biochem Press , 2012 , Article)Background/Aims: Vascular smooth muscle cells (VSMCs) play important roles, both in physiologic and pathophysiologic processes. Adhesion of these cells is critical for their proper functioning, especially in resistance-sized ... -
Colorectal and Prostate Cancer Risk in Diabetes: Metformin, an Actor behind the Scene
Anwar, M. Akhtar; Kheir, Wassim Abou; Eid, Stephanie; Fares, Joanna; Liu, Xiaoqi; Eid, Ali H.; Eid, Assaad A.... more authors ... less authors ( Ivyspring International Publisher , 2014 , Article)Both diabetes and cancer are prevalent diseases whose incidence rates are increasing worldwide, especially in countries that are undergoing rapid industrialization changes. Apparently, lifestyle risk factors including diet, ... -
Cyclic AMP-Rap1A signaling activates RhoA to induce α2c-adrenoceptor translocation to the cell surface of microvascular smooth muscle cells
Jeyaraj, Selvi C.; Unger, Nicholas T.; Eid, Ali H.; Mitra, Srabani; Paul El-Dahdah, N.; Quilliam, Lawrence A.; Flavahan, Nicholas A.; Chotani, Maqsood A.... more authors ... less authors ( American Physiological Society , 2012 , Article)Intracellular signaling by the second messenger cyclic AMP (cAMP) activates the Ras-related small GTPase Rap1 through the guanine exchange factor Epac. This activation leads to effector protein interactions, activation, ... -
Cyclic AMP-Rap1A signaling mediates cell surface translocation of microvascular smooth muscle α2C-adrenoceptors through the actin-binding protein filamin-2
Motawea, Hanaa K. B.; Jeyaraj, Selvi C.; Eid, Ali H.; Mitra, Srabani; Unger, Nicholas T.; Ahmed, Amany A. E.; Flavahan, Nicholas A.; Chotani, Maqsood A.... more authors ... less authors ( American Physiological Society , 2013 , Article)The second messenger cyclic AMP (cAMP) plays a vital role in vascular physiology, including vasodilation of large blood vessels. We recently demonstrated cAMP activation of Epac-Rap1A and RhoA-Rho-associated kinase ... -
Determination of vascular reactivity of middle cerebral arteries from stroke and spinal cord injury animal models using pressure myography
Anwar, Mohammad A.; Eid, Ali H. ( Humana Press Inc. , 2016 , Book chapter)Stroke and other neurovascular derangements are main causes of global death. They, along with spinal cord injuries, are responsible for being the principal cause of disability due to neurological and cognitive problems. ... -
Flavin Oxidase-Induced ROS Generation Modulates PKC Biphasic Effect of Resveratrol on Endothelial Cell Survival.
Posadino, Anna Maria; Giordo, Roberta; Cossu, Annalisa; Nasrallah, Gheyath K; Shaito, Abdullah; Abou-Saleh, Haissam; Eid, Ali H; Pintus, Gianfranco... more authors ... less authors ( MDPI , 2019 , Article)Dietary intake of natural antioxidants is thought to impart protection against oxidative-associated cardiovascular diseases. Despite many in vivo studies and clinical trials, this issue has not been conclusively resolved. ... -
Glucocorticoid-induced fetal origins of adult hypertension: Association with epigenetic events
Anwar, M. Akhtar; Saleh, Alaaeldin I.; Al Olabi, Reem; Al Shehabi, Tuqa S.; Eid, Ali H. ( Elsevier Inc. , 2016 , Article Review)Hypertension is a predominant risk factor for cardiovascular diseases and a major health care burden. Accumulating epidemiological and experimental evidence suggest that adult-onset hypertension may have its origins during ... -
Inflammogenesis of Secondary Spinal Cord Injury
Anwar, M. Akhtar; Al Shehabi, Tuqa S.; Eid, Ali H. ( Frontiers Media , 2016 , Article)Spinal cord injury (SCI) and spinal infarction lead to neurological complications and eventually to paraplegia or quadriplegia. These extremely debilitating conditions are major contributors to morbidity. Our understanding ... -
Inositol 1,4,5-Trisphosphate Receptors in Hypertension.
Eid, Ali H; El-Yazbi, Ahmed F; Zouein, Fouad; Arredouani, Abdelilah; Ouhtit, Allal; Rahman, Md M; Zayed, Hatem; Pintus, Gianfranco; Abou-Saleh, Haissam... more authors ... less authors ( Frontiers Media , 2018 , Article Review)Chronic hypertension remains a major cause of global mortality and morbidity. It is a complex disease that is the clinical manifestation of multiple genetic, environmental, nutritional, hormonal, and aging-related disorders. ... -
Mechanisms underlying the antihypertensive effects of garlic bioactives
Shouk, Reem; Abdou, Aya; Shetty, Kalidas; Sarkar, Dipayan; Eid, Ali H. ( Elsevier Inc. , 2014 , Article)Cardiovascular disease remains the leading cause of death worldwide with hypertension being a major contributing factor to cardiovascular disease–associated mortality. On a population level, non-pharmacological approaches, ... -
Molecular Insights Into SARS COV-2 Interaction With Cardiovascular Disease: Role of RAAS and MAPK Signaling
Wehbe, Zena; Hammoud, Safaa; Soudani, Nadia; Zaraket, Hassan; El-Yazbi, Ahmed; Eid, Ali H.... more authors ... less authors ( Frontiers Media S.A. , 2020 , Article)In December 2019, reports of viral pneumonia came out of Wuhan city in Hubei province in China. In early 2020, the causative agent was identified as a novel coronavirus (CoV) sharing some sequence similarity with SARS-CoV ... -
Resveratrol-mediated regulation of mitochondria biogenesis-associated pathways in neurodegenerative diseases: molecular insights and potential therapeutic applications.
Shaito, Abdullah; Al-Mansoob, Maryam; Ahmad, Salma M S; Haider, Mohammad Z; Eid, Ali H; Posadino, Anna Maria; Pintus, Gianfranco; Giordo, Roberta... more authors ... less authors ( Bentham Science Publisher , 2022 , Article Review)Neurodegenerative disorders include neurological conditions that affect nerve cells, causing the progressive loss of their functions and ultimately leading to loss of mobility, coordination, and mental functioning. The ... -
Rhus coriaria L. (Sumac) evokes endothelium-dependent vasorelaxation of rat aorta: Involvement of the cAMP and cGMP pathways
Anwar, Mohammad A.; Samaha, Ali A.; Baydoun, Safaa; Iratni, Rabah; Eid, Ali H. ( Frontiers Media S.A. , 2018 , Article)Rhus coriaria L. (sumac) is widely used in traditional remedies and cuisine of countries of the Mediterranean as well as Central and South-West Asia. Administration of sumac to experimental models and patients with diverse ... -
Salvia fruticosa Induces Vasorelaxation in Rat Isolated Thoracic Aorta: Role of the PI3K/Akt/eNOS/NO/cGMP Signaling Pathway
Anwar, M. Akhtar; Samaha, Ali A.; Ballan, Samar; Saleh, Alaaeldin I.; Iratni, Rabah; Eid, Ali H.... more authors ... less authors ( Nature Publishing Group , 2017 , Article)Salvia fruticosa (SF) Mill. is traditionally used for its antihypertensive actions. However, little is known about its pharmacologic and molecular mechanisms of action. Here we determined the effects of an ethanolic extract ...