Show simple item record

Author Scudiero, I.en_US
Author Vito, P.en_US
Author Stilo, R.en_US
Available date 2015-11-05T10:16:08Z
Publication Date 2014en_US
Publication Name Cellular Physiology
Citation Scudiero, I., Vito, P. and Stilo, R. (2014), The Three CARMA Sisters: So Different, So Similar: A Portrait of the Three CARMA Proteins and Their Involvement in Human Disorders. J. Cell. Physiol., 229: 990–997.en_US
ISSN 1097-4652en_US
URI http://dx.doi.org/10.1002/jcp.24543en_US
URI http://hdl.handle.net/10576/3700
Abstract Initially identified by their ability to modulate the functional activity of BCL10, the three CARMA proteins, CARMA1, -2, and -3, have recently themselves taken a leading role on the stage of molecular medicine. Although considered for some time as simple ancillary proteins, increasingly accumulating recent data evidently indicate a role of primary importance for these three proteins in the pathophysiology of several human tumors and inflammatory disorders. In fact, recent scientific literature clearly establishes that CARMA1 is one of the most mutated genes in a subtype of B-cell lymphoma and, at the same time, responsible for some rare human immunodeficiency conditions. On the other hand, mutations in CARMA2 are responsible for the hereditary transmission of some inflammatory disorders of the skin, including familial psoriasis and ptiriasis; whereas expression of CARMA3 appears to be deregulated in different human tumors. Here we describe and summarize the mutations found in the genes coding for the three CARMA proteins in these different human pathological conditions, and offer an interpretation of the molecular mechanisms from which arise the biological outcomes in which these proteins are involved.en_US
Language enen_US
Publisher Wiley Periodicals, Inc.en_US
Subject CARMA
Subject Human Disorders
Title The Three CARMA Sisters: So Different, So Similar: A Portrait of the Three CARMA Proteins and Their Involvement in Human Disordersen_US
Type Articleen_US
Issue Number 8en_US
Volume Number 229en_US


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record