Search
Now showing items 1-9 of 9
Utilization of the evidence from studies with no events in meta-analyses of adverse events: an empirical investigation
(
Springer
, 2021 , Article)
Zero-events studies frequently occur in systematic reviews of adverse events, which consist of an important source of evidence. We aimed to examine how evidence of zero-events studies was utilized in the meta-analyses of ...
Prevalence and determinants of symptomatic COVID-19 infection among children and adolescents in Qatar: A cross sectional analysis of 11445 individuals.
(
Cambridge University Press
, 2021 , Article)
There is a paucity of evidence about the prevalence and risk factors for symptomatic infection among children. This study aimed to describe the prevalence of symptomatic COVID-19 and its risk factors in children and ...
Metformin is comparable to insulin for pharmacotherapy in gestational diabetes mellitus: A network meta-analysis evaluating 6046 women.
(
Elsevier
, 2021 , Article)
The comparative efficacy of gestational diabetes (GDM) treatments lack conclusive evidence for choice of first-line treatment. The aim of this study was to compare the efficacy of metformin and glibenclamide to insulin ...
The odds ratio is “portable” but not the relative risk: Time to do away with the log link in binomial regression
(
Elsevier
, 2021 , Article)
Objectives: In a recent paper we suggest that the relative risk (RR) be replaced with the odds ratio (OR) as the effect measure of choice in clinical epidemiology. In response, Chu, and colleagues raise several points that ...
Overconfident results with the bivariate random effects model for meta-analysis of diagnostic accuracy studies
(
Wiley
, 2022 , Other)
Meta-analyses of diagnostic accuracy studies are a fundamental component of evidence-based medicine, and they are extensively used in medical imaging and the clinical laboratory. Techniques specifically developed to combine ...
Rapid evidence synthesis approach for limits on the search date: how rapid could it be?
(
John Wiley and Sons
, 2021 , Article)
Rapid reviews have been widely employed to support timely decision-making, and limiting the search date is the most popular approach in published rapid reviews. We assessed the accuracy and workload of search date limits ...
P-value driven methods were underpowered to detect publication bias: analysis of Cochrane review meta-analyses
(
Elsevier
, 2019 , Article)
To investigate the effect of number of studies in a meta-analysis on the detection of publication bias using p-value driven methods. The proportion of meta-analyses detected by Egger's, Harbord's, Peters', and Begg's tests ...
Immunogenicity after pre- and post-exposure rabies vaccination: A systematic review and dose-response meta-analysis
(
Elsevier
, 2021 , Article)
There are a myriad of vaccine schedules for rabies pre- (PrEP) and post-exposure prophylaxis (PEP) that differ in the number and timedoses, number of visits, length of schedule, and route of administration. The objective ...
Controversy and Debate: Questionable utility of the relative risk in clinical research: Paper 1: A call for change to practice
(
Elsevier
, 2020 , Article)
Background and Objectives
In clinical trials, the relative risk or risk ratio (RR) is a mainstay of reporting of the effect magnitude for an intervention. The RR is the ratio of the probability of an outcome in an ...