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Upper Versus Lower Gastrointestinal Delivery for Transplantation of Fecal Microbiota in Recurrent or Refractory Clostridium difficile Infection: A Collaborative Analysis of Individual Patient Data From 14 Studies
(
Wolters Kluwer
, 2017 , Article)
The aim of this study was to compare upper gastrointestinal (UGI) versus lower gastrointestinal (LGI) delivery routes of fecal microbiota transplantation (FMT) for refractory or recurrent/relapsing Clostridium difficile ...
Effect of Immediate Administration of Antibiotics in Patients With Sepsis in Tertiary Care: A Systematic Review and Meta-analysis
(
Elsevier
, 2017 , Article)
Purpose The goal of this review was to synthesize existing evidence regarding outcomes (mortality) for patients who present to the emergency department, are administered antibiotics immediately (within 1 hour) or later (>1 ...
Metformin is comparable to insulin for pharmacotherapy in gestational diabetes mellitus: A network meta-analysis evaluating 6046 women.
(
Elsevier
, 2021 , Article)
The comparative efficacy of gestational diabetes (GDM) treatments lack conclusive evidence for choice of first-line treatment. The aim of this study was to compare the efficacy of metformin and glibenclamide to insulin ...
A unified framework for bias assessment in clinical research
(
Lippincott, Williams & Wilkins
, 2019 , Article)
Methodological flaws, limitations, and inadequate practices in research are well known and pose threats to the internal validity of any research study. However, there are ways of safeguarding research conduct to reduce the ...
Metformin in pregnancy to avert gestational diabetes in women at high risk: Meta-analysis of randomized controlled trials.
(
Wiley
, 2019 , Article Review)
Previous randomized and observational studies on the efficacy of metformin in pregnancy to reduce incident gestational diabetes mellitus (GDM) in women at high risk (obesity, polycystic ovary syndrome [PCOS], or pregestational ...
The MethodologicAl STandards for Epidemiological Research (MASTER) scale demonstrated a unified framework for bias assessment
(
Elsevier
, 2021 , Article)
Objective: This paper presents a unified framework for assessment of the methodological quality of analytic study designs. Study Design and Setting: A systematic review of 393 methodological quality assessment tools that ...
Immunogenicity after pre- and post-exposure rabies vaccination: A systematic review and dose-response meta-analysis
(
Elsevier
, 2021 , Article)
There are a myriad of vaccine schedules for rabies pre- (PrEP) and post-exposure prophylaxis (PEP) that differ in the number and timedoses, number of visits, length of schedule, and route of administration. The objective ...
Effectiveness of Different Topical Treatments in the Healing of Pressure Injuries: A Network Meta-analysis.
(
Elsevier
, 2018 , Article)
Pressure injuries (PIs) are one of the most common types of complex wounds and impose a huge economic burden on the healthcare system and the patients. A plethora of topical treatments is widely available for PI treatment, ...
Prevalence of Differentiated Thyroid Cancer in Autopsy Studies Over Six Decades: A Meta-Analysis
(
American Society of Clinical Oncology
, 2016 , Article)
Differentiated thyroid cancer (DTC) incidence has been reported to have increased three- to 15-fold in the past few decades. It is unclear whether this represents overdiagnosis or a true increase in incidence. Therefore, ...