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The march of pluripotent stem cells in cardiovascular regenerative medicine.
(
BMC
, 2018 , Article Review)
Cardiovascular disease (CVD) continues to be the leading cause of global morbidity and mortality. Heart failure remains a major contributor to this mortality. Despite major therapeutic advances over the past decades, a ...
Antihypertensive indigenous lebanese plants: Ethnopharmacology and a clinical trial
(
MDPI AG
, 2019 , Article)
Hypertension is highly prevalent among the Lebanese adult population and is indeed the major cause of mortality in Lebanon. Traditional use of antihypertensive medicinal plants has long been practiced. The aim of this study ...
MicroRNAs as Potential Pharmaco-targets in Ischemia-Reperfusion Injury Compounded by Diabetes.
(
MDPI
, 2019 , Article)
Ischemia-Reperfusion (I/R) injury is the tissue damage that results from re-oxygenation of ischemic tissues. There are many players that contribute to I/R injury. One of these factors is the family of microRNAs (miRNAs), ...
Marjoram Relaxes Rat Thoracic Aorta Via a PI3-K/eNOS/cGMP Pathway.
(
MDPI
, 2019 , Article)
Despite pharmacotherapeutic advances, cardiovascular disease (CVD) remains the primary cause of global mortality. Alternative approaches, such as herbal medicine, continue to be sought to reduce this burden. is recognized ...
Flavin Oxidase-Induced ROS Generation Modulates PKC Biphasic Effect of Resveratrol on Endothelial Cell Survival.
(
MDPI
, 2019 , Article)
Dietary intake of natural antioxidants is thought to impart protection against oxidative-associated cardiovascular diseases. Despite many in vivo studies and clinical trials, this issue has not been conclusively resolved. ...
Flavonoids in hypertension: a brief review of the underlying mechanisms.
(
Elsevier
, 2019 , Article)
Flavonoids are a diverse group of bioactive polyphenolic compounds abundant in dietary plants and herbs. Regular consumption of flavonoids exerts cardio-vasculoprotective effects and may reduce the onset or progression of ...
Potential Adverse Effects of Resveratrol: A Literature Review.
(
MDPI
, 2020 , Article Review)
Due to its health benefits, resveratrol (RE) is one of the most researched natural polyphenols. Resveratrol's health benefits were first highlighted in the early 1990s in the French paradox study, which opened extensive ...
Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety
(
Frontiers Media S.A.
, 2020 , Article)
Cardiovascular diseases (CVDs) are a significant health burden with an ever-increasing
prevalence. They remain the leading causes of morbidity and mortality worldwide. The use
of medicinal herbs continues to be an ...
Cadmium induces migration of colon cancer cells: Roles of reactive oxygen species, p38 and cyclooxygenase-2
(
Cell Physiol Biochem Press GmbH & Co KG
, 2019 , Article)
Background/Aims: Cadmium (Cd) is a heavy metal contaminant whose toxicity is associated with colorectal cancer (CRC). However, the underlying molecular mechanisms of Cd-induced CRC malignancy remain obscure. Methods: A ...
Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms
(
Elsevier
, 2022 , Article)
Cancer is a leading cause of morbidity and mortality around the globe. Reactive oxygen species (ROS) play contradicting roles in cancer incidence and progression. Antioxidants have attracted attention as emerging therapeutic ...