Browsing Biomedical Research Center by Author "Al Moustafa, Ala-Eddin"
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A comprehensive review on the antiviral activities of chalcones
Elkhalifa, Dana; Al-Hashimi, Israa; Al Moustafa, Ala-Eddin; Khalil, Ashraf ( Taylor and Francis Ltd. , 2021 , Article)Some viral outbreaks have plagued the world since antiquity, including the most recent COVID-19 pandemic. The continuous spread and emergence of new viral diseases have urged the discovery of novel treatment options that ... -
A comprehensive review summarizing the recent biomedical applications of functionalized carbon nanofibers
Abdo, Ghada G.; Zagho, Moustafa M.; Al Moustafa, Ala-Eddin; Khalil, Ashraf; Elzatahry, Ahmed A. ( John Wiley and Sons Inc , 2021 , Article)Since the discovery and fabrication of carbon nanofibers (CNFs) over a decade ago, scientists foster to discover novel myriad potential applications for this material in both biomedicine and industry. The unique economic ... -
Association between waterpipe smoking and obesity: Population-based study in Qatar
Alkeilani, Abdulla A.; Khalil, Abdelrahman A.; Azzan, Afaf M.; Al-Khal, Noof A.; Al-Nabit, Noora H.; Talab, Omar M.; Al-Hajri, Rahaf A.; Rahmoon, Samreen M.; Ashour, Anas A.; Gupta, Ishita; Al Moustafa, Ala-Eddin... more authors ... less authors ( European Publishing , 2022 , Article)Introduction: Over the past decade obesity prevalence has been increasing rapidly in the Gulf region (GR) including Qatar, becoming one of the major health issues in the region. Concomitantly, waterpipe (WP) smoking is ... -
Breast Cancer During Pregnancy: A Marked Propensity to Triple-Negative Phenotype.
Allouch, Soumaya; Gupta, Ishita; Malik, Shaza; Al Farsi, Halema F; Vranic, Semir; Al Moustafa, Ala-Eddin... more authors ... less authors ( Frontiers Media , 2020 , Article)Breast and cervical cancers comprise 50% of all cancers during pregnancy. In particular, gestational breast cancer is considered one of the most aggressive types of cancers, which is a rare but fatal disease. However, the ... -
Co-Incidence of Epstein-Barr Virus and High-Risk Human Papillomaviruses in Cervical Cancer of Syrian Women.
Al-Thawadi, Hamda; Ghabreau, Lina; Aboulkassim, Tahar; Yasmeen, Amber; Vranic, Semir; Batist, Gerald; Al Moustafa, Ala-Eddin... more authors ... less authors ( Frontiers Media , 2018 , Article)Epstein-Barr virus (EBV) has been recently shown to be co-present with high-risk human papillomaviruses (HPVs) in human cervical cancer; thus, these oncoviruses play an important role in the initiation and/or progression ... -
Co-incidence of Human Papillomaviruses and Epstein-Barr Virus Is Associated With High to Intermediate Tumor Grade in Human Head and Neck Cancer in Syria.
Gupta, Ishita; Ghabreau, Lina; Al-Thawadi, Hamda; Yasmeen, Amber; Vranic, Semir; Al Moustafa, Ala-Eddin; Malki, Mohammed I... more authors ... less authors ( Frontiers Media , 2020 , Article)High-risk human papillomaviruses (high-risk HPVs) have been recently reported to be co-present with Epstein-Barr virus (EBV) in different types of human cancers including head and neck (HN), where they can cooperate in the ... -
Co-presence of human papillomaviruses and Epstein-Barr virus is linked with advanced tumor stage: a tissue microarray study in head and neck cancer patients.
Al-Thawadi, Hamda; Gupta, Ishita; Jabeen, Ayesha; Skenderi, Faruk; Aboulkassim, Tahar; Yasmeen, Amber; Malki, Mohammed I; Batist, Gerald; Vranic, Semir; Al Moustafa, Ala-Eddin... more authors ... less authors ( BMC , 2020 , Article)Human papillomaviruses (HPVs) and Epstein-Barr virus (EBV), known oncoviruses, can be co-present and cooperate in the initiation and/or progression of human carcinomas, including head and neck. Based on this fact, we ... -
Co-prevalence of Epstein-Barr virus and high-risk human papillomaviruses in Syrian women with breast cancer.
Al Moustafa, Ala-Eddin; Al-Antary, Noor; Aboulkassim, Tahar; Akil, Nizar; Batist, Gerald; Yasmeen, Amber... more authors ... less authors ( Taylor & Francis , 2016 , Article)ABSTRAT We recently performed 2 studies viewing the presence of Epstein-Barr virus (EBV) and high-risk human papillomaviruses (HPVs) types 16, 18, 31, 33 and 35 in human breast cancer in the Syrian population. Herein, we ... -
Crosstalk between HER2 and PD-1/PD-L1 in Breast Cancer: From Clinical Applications to Mathematical Models.
Padmanabhan, Regina; Kheraldine, Hadeel Shafeeq; Meskin, Nader; Vranic, Semir; Al Moustafa, Ala-Eddin ( Springer , 2020 , Article)Breast cancer is one of the major causes of mortality in women worldwide. The most aggressive breast cancer subtypes are human epidermal growth factor receptor-positive (HER2) and triple-negative breast cancers. Therapies ... -
Design, synthesis, and validation of novel nitrogen-based chalcone analogs against triple negative breast cancer
Elkhalifa, Dana; Siddique, Abu Bakar; Qusa, Mohammed; Cyprian, Farhan S.; El Sayed, Khalid; Alali, Feras; Al Moustafa, Ala-Eddin; Khalil, Ashraf... more authors ... less authors ( Elsevier Masson s.r.l. , 2020 , Article)Great strides have been made in triple negative breast cancer (TNBC) treatment, which represents 20% of total predicted annual US breast cancer (BC) cases. Despite the development of several therapeutics, TNBC patients ... -
Developmental Toxicity of Surface-Modified Gold Nanorods in the Zebrafish Model
Zakaria, Zain Z; Mahmoud, Nouf N; Benslimane, Fatiha M; Yalcin, Huseyin C.; Al Moustafa, Ala-Eddin; Al-Asmakh, Maha... more authors ... less authors ( American Chemical Society , 2022 , Article)Background: nanotechnology is one of the fastest-growing areas, and it is expected to have a substantial economic and social impact in the upcoming years. Gold particles (AuNPs) offer an opportunity for wide-ranging ... -
E-cadherin/catenin complex modulations in human oral cancer
Al Moustafa, Ala Eddin; Yasmeen, Amber ( Springer Netherlands , 2015 , Book chapter)Oral cancer is a common neoplasm in both male and female worldwide; the incidence and mortality of this cancer have increased over the past decades. Cancer metastasis is a major cause of morbidity and mortality in oral ... -
E-Cigarette Liquid Provokes Significant Embryotoxicity and Inhibits Angiogenesis.
Ashour, Anas; Alhussain, Hashim; Rashid, Umar Bin; Abughazzah, Labiba; Gupta, Ishita; Malki, Ahmed; Vranic, Semir; Al Moustafa, Ala-Eddin... more authors ... less authors ( MDPI , 2020 , Article)E-cigarette smoking (ECS) is a new method of tobacco smoking that is gaining popularity as it is thought to be a "healthy method" of tobacco consumption. The adverse outcomes of ECS on the respiratory and cardiovascular ... -
E5 and E6/E7 of high-risk HPVs cooperate to enhance cancer progression through EMT initiation
Al Moustafa, Ala-Eddin ( Taylor & Francis , 2015 , Article)It is estimated that 10–20% of human carcinogenesis is linked to virus infection including papillomaviruses (HPVs). Moreover, since metastatic cancer disease is a major cause of morbidity and mortality in cancer patients, ... -
Effect of Water-Pipe Smoking on the Normal Development of Zebrafish
Zakaria, Zain Zaki; Aladwi, Shaima Ahmad; Benslimane, Fatiha; Al-Absi, Enas S.; Al-Shafai, Mashael; Yalcin, Huseyin C.; Khalil, Ashraf; Al Moustafa, Ala-Eddin; Al-Asmakh, Maha... more authors ... less authors ( MDPI , 2021 , Article)Background: Among all types of tobacco consumption,Water-Pipe Smoking (WPS) is the most widely used in the Middle East and second-most in several other countries. The effect of WPS on normal development is not yet fully ... -
Elaeagnus angustifolia Plant Extract Induces Apoptosis via P53 and Signal Transducer and Activator of Transcription 3 Signaling Pathways in Triple-Negative Breast Cancer Cells
Fouzat, Arij; Hussein, Ola Jihad; Gupta, Ishita; Al-Farsi, Halema F.; Khalil, Ashraf; Al Moustafa, Ala Eddin... more authors ... less authors ( Frontiers Media , 2022 , Article)Elaeagnus angustifolia (EA) is used as an alternative medicine in the Middle East to manage numerous human diseases. We recently reported that EA flower extract inhibits cell proliferation and invasion of human oral and ... -
Elaeagnus angustifolia Plant Extract Inhibits Epithelial-Mesenchymal Transition and Induces Apoptosis via HER2 Inactivation and JNK Pathway in HER2-Positive Breast Cancer Cells
Jabeen, Ayesha; Sharma, Anju; Gupta, Ishita; Kheraldine, Hadeel; Vranic, Semir; Al Moustafa, Ala-Eddin; Al Farsi, Halema F... more authors ... less authors ( MDPI , 2020 , Article)Elaeagnus angustifolia (EA) is a medicinal plant used for treating several human diseases in the Middle East. Meanwhile, the outcome of extract on HER2-positive breast cancer remains nascent. Thus, we herein investigated ... -
Emerging innate biological properties of nano-drug delivery systems: A focus on PAMAM dendrimers and their clinical potential
Kheraldine, Hadeel; Rachid, Ousama; M Habib, Abdella; Al Moustafa, Ala-Eddin; F. Benter, Ibrahim ( Elsevier , 2021 , Article)Drug delivery systems or vectors are usually needed to improve the bioavailability and effectiveness of a drug through improving its pharmacokinetics/pharmacodynamics at an organ, tissue or cellular level. However, emerging ... -
Epstein-Barr Virus and Human Papillomaviruses Interactions and Their Roles in the Initiation of Epithelial-Mesenchymal Transition and Cancer Progression.
Cyprian, Farhan S; Al-Farsi, Halema F; Vranic, Semir; Akhtar, Saghir; Al Moustafa, Ala-Eddin ( Frontiers Media , 2018 , Article Review)Oncoviruses are implicated in around 20% of all human cancers including both solid and non-solid malignancies. Epstein-Barr virus (EBV) and human papillomaviruses (HPVs) are the most common oncoviruses worldwide. Currently, ... -
Epstein-Barr virus and its association with Fascin expression in colorectal cancers in the Syrian population: A tissue microarray study.
Al-Antary, Noor; Farghaly, Hanan; Aboulkassim, Tahar; Yasmeen, Amber; Akil, Nizar; Al Moustafa, Ala-Eddin... more authors ... less authors ( Taylor & Francis , 2017 , Article)Colorectal cancer (CRC) is the third most common malignancy in both men and women worldwide. Colorectal carcinogenesis is a complex, multistep process involving environmental and lifestyle features as well as sequential ...