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المؤلفAl-Asmakh, Maha
المؤلفRace, H
المؤلفTan, S
المؤلفSullivan, M.H.F.
تاريخ الإتاحة2018-02-12T08:15:09Z
تاريخ النشر2007-03-01
اسم المنشورMolecular Human Reproduction
المعرّفhttp://dx.doi.org/10.1093/molehr/gal109
الاقتباسM. Al-Asmakh, H. Race, S. Tan, M.H.F. Sullivan; The effects of oxygen concentration on in vitro output of prostaglandin E2 and interleukin-6 from human fetal membranes, MHR: Basic science of reproductive medicine, Volume 13, Issue 3, 1 March 2007, Pages 197–201, https://doi.org/10.1093/molehr/gal109
الرقم المعياري الدولي للكتاب1360-9947
معرّف المصادر الموحدhttp://hdl.handle.net/10576/6335
الملخصLabour at all gestational ages has clear biochemical parallels with an inflammatory response, typified by the increased output of prostaglandins (PGs) and cytokines within the pregnant uterus. The main sources are the fetal membranes, including the amnion, chorion and decidua, and it is well established that stimuli [bacteria, bacterial endotoxins, interleukin (IL)-1beta, corticotrophin releasing hormone and platelet activating factor], as well as negative regulators (progesterone and IL-10), control the net output of PGs and cytokines in vitro. In this study, we have investigated the effect of oxygen tension on fetal membrane biology, as a reconsideration of the literature suggests that fetal membranes are normally exposed to approximately 3% O(2) (approximately 20 mmHg) in vivo, rather than the 20% O(2) (150 mmHg) used for in vitro culture. The output of prostaglandin E(2) from non-activated fetal membranes in response to IL-1beta was decreased by approximately 80% at 16 and 24 h of culture, whereas the inhibition of IL-6 production was time-dependent, reaching 90% after 16 h and 50% after 24 h. Tissues obtained after labour (or after the activation of inflammatory processes leading to labour) were not inhibited by the low levels of oxygen, indicating that only before the onset of labour does oxygen regulate fetal membrane biology. The data identify oxygen as a regulator of fetal membrane inflammatory functions during human pregnancy, and its mechanism of action requires further study.
اللغةen
الناشرOxford University Press
الموضوعfetal membranes
inhibition
interleukin-6
oxygen
prostaglandin E2
العنوانThe effects of oxygen concentration on in vitro output of prostaglandin E2 and interleukin-6 from human fetal membranes.
النوعArticle
الصفحات197-201
رقم العدد3
رقم المجلد13
ESSN1460-2407
dc.accessType Abstract Only


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