Synthesis and biological testing of 2,4-disubstituted thiazole derivatives as Potential antitumor antibiotics
MetadataShow full item record
A series of thiazole derivatives bearing amino, acetamido or thioureido synthons at position 2- and thiosemicarbazone or 1,2,4-triazolethione moieties at position 4- have been synthesized and evaluated for their antimicrobial and antitumor activities. Some of the tested compounds (5,6,14 and 15) proved to possess ^remarkable antitumor antibiotic activity. The antimicrobial potency is found mainly to be against Gram positive bacterfa. The detailed synthesis, spectroscopic and biological data are reported.
- Qatar University Science Journal - [From 1981 TO 2007] [770 items ]