Browsing by Author "Hindy, George"

Now showing items 1-4 of 4

    • Association of Habitual Alcohol Intake with Risk of Cardiovascular Disease 

      Biddinger, Kiran J.; Emdin, Connor A.; Haas, Mary E.; Wang, Minxian; Hindy, George; ... more authors ( American Medical Association , 2022 , Article)
      Importance: Observational studies have consistently proposed cardiovascular benefits associated with light alcohol consumption, while recent genetic analyses (ie, mendelian randomization studies) have suggested a possible ...

    • Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis 

      Kanoni, Stavroula; Graham, Sarah E.; Wang, Yuxuan; Surakka, Ida; Ramdas, Shweta; ... more authors ( BioMed Central , 2022 , Article)
      Background: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding ...

    • A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids 

      Ramdas, Shweta; Judd, Jonathan; Graham, Sarah E.; Kanoni, Stavroula; Wang, Yuxuan; ... more authors ( Elsevier , 2022 , Article)
      A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ...

    • The power of genetic diversity in genome-wide association studies of lipids 

      Graham, Sarah E.; Clarke, Shoa L.; Wu, Kuan Han H.; Kanoni, Stavroula; Zajac, Greg J.M.; ... more authors ( Nature Research , 2021 , Article)
      Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different dietary patterns and medication use1. Despite advances in prevention and treatment, in ...