Browsing by Author "Yalcin, Huseyin C"
Now showing items 1-20 of 74
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Adaptation of a Mice Doppler Echocardiography Platform to Measure Cardiac Flow Velocities for Embryonic Chicken and Adult Zebrafish.
( Frontiers Media , 2019 , Article)Ultrasonography is the most widely used imaging technique in cardiovascular medicine. In this technique, a piezoelectric crystal produces, sends, and receives high frequency ultrasound waves to the body to create an image ... -
Application of a flow-induced stress wave and investigation of associated injuries on cell monolayers using a parallel plate flow chamber
( MDPI , 2020 , Article)© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Parallel plate flow chambers are widely used to expose cultured cells to physiological flows for the investigation of a variety of diseases. These applications ... -
Assessment of calcified aortic valve leaflet deformations and blood flow dynamics using fluid-structure interaction modeling
( Elsevier , 2017 , Article)Aortic valve diseases are among the most common cardiovascular defects. Since a non-functioning valve results in disturbed blood flow conditions, the diagnosis of such defects is based on identification of stenosis via ... -
Assessment of calcified aortic valve leaflet deformations and blood flow dynamics using fluid-structure interaction modeling
( Elsevier , 2017 , Article)Aortic valve diseases are among the most common cardiovascular defects. Since a non-functioning valve results in disturbed blood flow conditions, the diagnosis of such defects is based on identification of stenosis via ... -
Assessment of Human Fetal Left Heart Hemodynamics during Prenatal Development
( Qatar University Press , 2021 , Poster)The hemodynamic forces and wall shear stresses (WSS) play an important role during the fetal heart development. Abnormal levels of flow-driven shear stress can deteriorate the proper functioning of the cells responsible ... -
Autoimmune Diseases of the GI Tract Part I: Etiology and Pathophysiology
( IntechOpen , 2022 , Book chapter)Autoimmune diseases have emerged as a pandemic in our modern societies, especially after World War II. There are currently more than 80 autoimmune diseases that compromise the lives of millions of patients around the world. ... -
Autoimmune Diseases of the GI Tract Part II: Emergence of Diagnostic Tools and Treatments
( IntechOpen , 2022 , Book chapter)Autoimmune diseases (AD) have emerged as a pandemic in our modern societies, especially after the World War II. In part I, we have reviewed five main diseases and shed light on different aspects from introducing the concept ... -
Cardiac function and blood flow hemodynamics assessment of zebrafish (Danio rerio) using high-speed video microscopy
( Elsevier , 2020 , Article)BackgroundIn the last few decades, zebrafish (Danio rerio) were introduced as a model organism to investigate human diseases including cardiovascular and neuronal disorders. In most zebrafish investigations, cardiac function ... -
Characterization of Endothelial Cilia Distribution During Cerebral-Vascular Development in Zebrafish (Danio rerio)
( American Heart Association , 2018 , Article)Objective—Endothelial cells (ECs) sense and respond to flow-induced mechanical stress, in part, via microtubule-based projections called primary cilia. However, many critical steps during vascular morphogenesis occur ... -
Characterization of MXene as a Cancer Photothermal Agent Under Physiological Conditions
( Frontiers Media , 2021 , Article)A growing interest has recently emerged in the use of nanomaterials in medical applications. Nanomaterials, such as MXene, have unique properties due to their 2D ultra-thin structure, which is potentially useful in cancer ... -
Cilia proteins are biomarkers of altered flow in the vasculature
( American Society for Clinical Investigation , 2022 , Article)Cilia, microtubule-based organelles that project from the apical luminal surface of endothelial cells (ECs), are widely regarded as low-flow sensors. Previous reports suggest that upon high shear stress, cilia on the EC ... -
Comparative Analysis of In Vitro Pumps Used in Cardiovascular Investigations: Focus on Flow Generation Principles and Characteristics of Generated Flows
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)A comprehensive analysis of in vitro pumps used in cardiovascular research is provided in this review, with a focus on the characteristics of generated flows and principles of flow generations. The cardiovascular system, ... -
Computational Analysis of Wall Shear Stress Patterns on Calcified and Bicuspid Aortic Valves : Focus on Radial and Coaptation Patterns
( MDPI , 2021 , Article)Calcification and bicuspid valve formation are important aortic valve disorders that disturb the hemodynamics and the valve function. The detailed analysis of aortic valve hemodynamics would lead to a better understanding ... -
Correction to: S.I.: Emerging material science trends in Nanomedicine, Biosensor, Microfluidics and 3D Bioprinting technologies (Emergent Materials, (2025), 10.1007/s42247-025-01064-1)
( Springer Nature , 2025 , Article)The Editorial article "Emerging material science trends in Nanomedicine, Biosensor, Microfluidics and 3D Bioprinting technologieswas", written by Huseyin C.Yalcin, Nureddin Ashammakhi and Itthipon Jeerapan, was planned to ... -
Deep Learning Technique for Congenital Heart Disease Detection Using Stacking-Based CNN-LSTM Models from Fetal Echocardiogram: A Pilot Study
( IEEE , 2023 , Article)Congenital heart defects (CHDs) are a leading cause of death in infants under 1 year of age. Prenatal intervention can reduce the risk of postnatal serious CHD patients, but current diagnosis is based on qualitative criteria, ... -
Design and Microinjection of Morpholino Antisense Oligonucleotides and mRNA into Zebrafish Embryos to Elucidate Specific Gene Function in Heart Development
( MyJove Corporation , 2022 , Article)The morpholino oligomer-based knockdown system has been used to identify the function of various gene products through loss or reduced expression. Morpholinos (MOs) have the advantage in biological stability over DNA oligos ... -
DEVELOPMENT AND IN VIVO TESTING OF SMART NANOPARTICLES FOR ENHANCED ANTI-CANCER ACTIVITY AND REDUCED CARDIOTOXICITY ASSOCIATED WITH TYROSINE KINASE INHIBITORS
(2021 , Master Thesis)Tyrosine kinase inhibitors (TKIs) are new generation of anti-cancer drugs with very high efficiency against cancer cells. However, TKIs are associated with severe cardiotoxicity limiting their clinical benefits. One ... -
Development of Recombinant PLC-Zeta Protein as a Therapeutic Intervention for the Clinical Treatment of Oocyte Activation Failure
( MDPI , 2024 , Article)The sperm-specific phospholipase C zeta (PLCζ) protein is widely considered as the predominant physiological stimulus for initiating the Ca2+ release responsible for oocyte activation during mammalian fertilization. The ... -
Developmental Toxicity of Surface-Modified Gold Nanorods in the Zebrafish Model
( American Chemical Society , 2022 , Article)Background: nanotechnology is one of the fastest-growing areas, and it is expected to have a substantial economic and social impact in the upcoming years. Gold particles (AuNPs) offer an opportunity for wide-ranging ... -
Dexamethasone and transdehydroandrosterone significantly reduce pulmonary epithelial cell injuries associated with mechanical ventilation.
( American Physiological Society , 2021 , Article)Many patients who suffer from pulmonary diseases cannot inflate their lungs normally, as they need mechanical ventilation (MV) to assist them. The stress associated with MV can damage the delicate epithelium in small airways ...
