Browsing by Author "Alali, Feras Q."
Now showing items 1-12 of 12
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ANO4 Expression Is a Potential Prognostic Biomarker in Non-Metastasized Clear Cell Renal Cell Carcinoma
Al Sharie, Ahmed H.; Al Zu’bi, Yazan O.; El-Elimat, Tamam; Al-Kammash, Kinda; Abu Lil, Alma; Isawi, Israa H.; Al Sharie, Sarah; Abu Mousa, Balqis M.; Al Malkawi, Abubaker A.; Alali, Feras Q.... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)Background: Over the past decade, transcriptome profiling has elucidated many pivotal pathways involved in oncogenesis. However, a detailed comprehensive map of tumorigenesis remains an enigma to solve. Propelled research ... -
Anticancer activity of Neosetophomone B by targeting AKT/SKP2/MTH1 axis in leukemic cells
Kuttikrishnan, Shilpa; Bhat, Ajaz A.; Mateo, Jericha M.; Ahmad, Fareed; Alali, Feras Q.; El-Elimat, Tamam; Oberlies, Nicholas H.; Pearce, Cedric J.; Uddin, Shahab... more authors ... less authors ( Elsevier , 2022 , Article)Neosetophomone B (NSP–B), a meroterpenoid fungal secondary metabolite, was investigated for its anticancer potential in leukemic cell lines (K562 and U937). NSP-B treatment of leukemic cells suppressed cell viability by ... -
Bioinformatics Analysis Reveals FOXM1/BUB1B Signaling Pathway as a Key Target of Neosetophomone B in Human Leukemic Cells: A Gene Network-Based Microarray Analysis
Kuttikrishnan, Shilpa; Masoodi, Tariq; Sher, Gulab; Bhat, Ajaz A.; Patil, Kalyani; El-Elimat, Tamam; Oberlies, Nicholas H.; Pearce, Cedric J.; Haris, Mohmmad; Ahmad, Aamir; Alali, Feras Q.; Uddin, Shahab... more authors ... less authors ( Frontiers Media S.A. , 2022 , Article)Abnormal expression of Forkhead box protein M1 (FOXM1) and serine/threonine kinase Budding uninhibited by benzimidazoles 1 (BUB1B) contributes to the development and progression of several cancers, including chronic ... -
Evaluation of the effect of hypericum triquetrifolium turra on memory impairment induced by chronic psychosocial stress in rats: Role of BDNF
Alzoubi, Karem H.; Abdel-Hafiz, Laila; Khabour, Omar F.; El-Elimat, Tamam; Alzubi, Mohammad A.; Alali, Feras Q.... more authors ... less authors ( Taylor & Francis Group , 2020 , Article)Background: Chronic psychosocial stress impairs memory function and leads to a depression-like phenotype induced by a persistent status of oxidative stress. Hypericum perforatum L. (St. John’s wort) is widely used to relieve ... -
Evaluation of the Wound Healing Potential of Hypericum triquetrifolium Turra: An Experimental Animal Study and Histopathological Examination
El-Elimat, Tamam; El-Qaderi, Haya S.; Hananeh, Wael M.; Abu AlSamen, Mahmoud M.; Al Sharie, Ahmed H.; Alshehabat, Musa A.; Al-Gharaibeh, Mohammad; Alali, Feras Q.... more authors ... less authors (2023 , Article)The wound healing potential of the aerial parts of Hypericum triquetrifolium Turra (Hypericaceae) was evaluated using an in vivo excision wound model in rats. Adult male Sprague Dawley rats were randomly assigned into seven ... -
Exploring the in vivo anti-cancer potential of Neosetophomone B in leukemic cells using a zebrafish xenograft model
Kuttikrishnan, Shilpa; Hasan, Maram; Prabhu, Kirti S.; El-Elimat, Tamam; Oberlies, Nicholas H.; Pearce, Cedric J.; Alali, Feras Q.; Ahmad, Aamir; Pourkarimi, Ehsan; Bhat, Ajaz A.; Yalcin, Huseyin C.; Uddin, Shahab... more authors ... less authors ( Elsevier Inc. , 2024 , Article)Neosetophomone B (NSP–B) is a unique meroterpenoid fungal secondary metabolite that has previously demonstrated promising anti-cancer properties against various cancer cell lines in vitro. However, its in vivo anti-cancer ... -
Natural resorcylic acid lactones: A chemical biology approach for anticancer activity
Shilpa, Kuttikrishnan; Prabhu, Kirti S.; Al Sharie, Ahmed H.; Al Zu'bi, Yazan O.; Alali, Feras Q.; Oberlies, Nicholas H.; Ahmad, Aamir; El-Elimat, Tamam; Uddin, Shahab... more authors ... less authors ( Elsevier , 2022 , Article)Resorcylic acid lactones (RALs) are fungal polyketides that consist of a β-resorcylic acid residue (2,4-dihydroxybenzoic acid) embedded in a macrolactone ring. RALs exhibit a broad range of biological activities, including ... -
Neosetophomone B induces apoptosis in multiple myeloma cells via targeting of AKT/SKP2 signaling pathway
Kuttikrishnan, Shilpa; Ahmad, Fareed; Mateo, Jericha M.; Prabhu, Kirti S.; El-Elimat, Tamam; Oberlies, Nicholas H.; Pearce, Cedric J.; Akil, Ammira S.Alshabeeb; Bhat, Ajaz A.; Alali, Feras Q.; Uddin, Shahab... more authors ... less authors ( Wiley-Blackwell , 2023 , Article)Multiple myeloma (MM) is a hematologic malignancy associated with malignant plasma cell proliferation in the bone marrow. Despite the available treatments, drug resistance and adverse side effects pose significant challenges, ... -
Phenethyisoquinoline alkaloids from the leaves of Androcymbium palaestinum
Tamam, El-Elimat; Alhawarri, Maram B.; Rivera-Chávez, José; Burdette, Joanna E.; Czarnecki, Austin; Al-Gharaibeh, Mohammad; Al Sharie, Ahmed H.; Alhusban, Ahmed; Alali, Feras Q.; Oberlies, Nicholas H.... more authors ... less authors ( Elsevier , 2020 , Article)Thirteen compounds were isolated from the methanolic extract of the leaves of Androcymbium palaestinum Baker (Colchicaceae). Of these, three were new, two were new natural products, and eight were known. The new isolated ... -
Recent developments on (−)-colchicine derivatives: Synthesis and structure-activity relationship
Abdullah A., Ghawanmeh; Al-Bajalan, Hussein M.; Mackeen, Mukram Mohamed; Alali, Feras Q.; Chong, Kwok Feng ( Elsevier , 2020 , Article Review)(−)-Colchicine, an anti-microtubulin polymerization agent, is a valuable medication and the drug of choice for gout, Behçet’s disease and familial Mediterranean fever. It has a narrow therapeutic index due to its high ... -
Thiostrepton inhibits growth and induces apoptosis by targeting FoxM1/SKP2/MTH1 axis in B-precursor acute lymphoblastic leukemia cells
Kuttikrishnan, Shilpa; Prabhu, Kirti S.; Khan, Abdul Q.; Alali, Feras Q.; Ahmad, Aamir; Uddin, Shahab... more authors ... less authors ( Taylor and Francis Group , 2021 , Article)Forkhead box M1 (FoxM1) is a transcription factor that plays an important role in the etiology of many cancers, however, its role has not been elucidated in B-precursor acute lymphoblastic leukemia (B-pre-ALL). In the ... -
Vascular endothelial growth factor (VEGF) signaling in tumour vascularization: Potential and challenges
Siveen, Kodappully Sivaraman; Prabhu, Kirti; Krishnankutty, Roopesh; Kuttikrishnan, Shilpa; Tsakou, Magdalini; Alali, Feras Q.; Dermime, Said; Mohammad, Ramzi M.; Uddin, Shahab... more authors ... less authors ( Bentham , 2017 , Article)Angiogenesis is defined as the physiological process by which new blood vessels develop from pre-existing vessels; either by sprouting or intussusception. Inhibition of angiogenesis is one of the most encouraging strategies ...