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    Natural resorcylic acid lactones: A chemical biology approach for anticancer activity

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    1-s2.0-S1359644621004323-main.pdf (2.101Mb)
    Date
    2022-02-28
    Author
    Shilpa, Kuttikrishnan
    Prabhu, Kirti S.
    Al Sharie, Ahmed H.
    Al Zu'bi, Yazan O.
    Alali, Feras Q.
    Oberlies, Nicholas H.
    Ahmad, Aamir
    El-Elimat, Tamam
    Uddin, Shahab
    ...show more authors ...show less authors
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    Abstract
    Resorcylic acid lactones (RALs) are fungal polyketides that consist of a β-resorcylic acid residue (2,4-dihydroxybenzoic acid) embedded in a macrolactone ring. RALs exhibit a broad range of biological activities, including anticancer activities. Following discovery of the selective Hsp90 inhibition activity of radicicol, the kinase inhibition activity of hypothemycin, monocillin II, 5Z-7-oxo-zeaenol, and L-783,277 RALs, and the nuclear factor kappa B (NF-κB) inhibition activity of the RAL zearalenone, have attracted great attention as potential therapeutics for cancer treatment. In this minireview, we focus on natural RALs that possess cytotoxic activities [IC50 values < 10 μM (or 4–5 μg/ml)], discussing their structures, isolation, occurrence, biological activities, and anticancer molecular mechanisms.
    URI
    https://www.sciencedirect.com/science/article/pii/S1359644621004323
    DOI/handle
    http://dx.doi.org/10.1016/j.drudis.2021.10.001
    http://hdl.handle.net/10576/41837
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    • Laboratory Animal Research Center (Research) [‎129‎ items ]
    • Pharmacy Research [‎1389‎ items ]
    • QU Health Research [‎110‎ items ]

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