تصفح حسب المؤلف "Suleiman, Muna"
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The role of CD44, hyaluronan and NHE1 in cardiac remodeling.
Suleiman, Muna; Abdurrahman, Nabeel; yalcin, huseyin c; Mraiche, Fatima ( Elsevier , 2018 , Article)Cardiac remodeling, characterized by excessive extracellular matrix (ECM) remodeling, predisposes the heart to failure if left unresolved. Understanding the signaling mechanisms involved in excessive extracellular matrix ... -
The Role of p90 Ribosomal S6 Kinase (RSK) in Tyrosine Kinase Inhibitor (TKI)-Induced Cardiotoxicity
Suleiman, Muna; Al Najjar, Afnan; Zakaria, Zain Z.; Ahmed, Rashid; Yalcin, Huseyin C.; Korashy, Hesham M.; Uddin, Shahab; Riaz, Sadaf; Abdulrahman, Nabeel; Mraiche, Fatima... more authors ... less authors ( Springer , 2023 , Article Review)Targeted therapy, such as tyrosine kinase inhibitors (TKIs), has been approved to manage various cancer types. However, TKI-induced cardiotoxicity is a limiting factor for their use. This issue has raised the need for ... -
THE ROLE OF P90 RIBOSOMAL S6 KINASE AND AUTOPHAGY IN SUNITINIB AND PONATINIB-INDUCED CARDIOTOXICITY
SULEIMAN, MUNA (2019 , Master Thesis)In recent years, the paradigm cancer management has shifted towards a targeted approach. Among the newly targeted anticancer therapies are ponatinib and sunitinib, small molecules tyrosine kinase inhibitors (TKIs), used ... -
The Cellular Interplay Between CD44 and Na+/H+ Exchanger1 in Cardiac Remodeling
Mraiche, Fatima; Suleiman, Muna; Abdulrahman, Nabeel; Joseph, Jensa ( Hamad bin Khalifa University Press (HBKU Press) , 2018 , Conference Paper)Background: Extracellular matrix (ECM) remodeling is a characteristic feature of cardiac remodeling which, if left untreated, progresses to heart failure. Cardiac fibroblasts, the major cellular component of the myocardium, ...