Browsing by Author "Elhissi, Abdelbary"
Now showing items 1-20 of 39
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A simple approach to predict the stability of phospholipid vesicles to nebulization without performing aerosolization studies
( Elsevier B.V. , 2016 , Article)Membrane extrusion was investigated for predicting the stability of soya phosphatidylcholine liposomes and surfactosomes (Tween 80-enriched liposomes) to nebulization. Formulations were prepared with or without cholesterol, ... -
Amlexanox-loaded nanoliposomes showing enhanced anti-inflammatory activity in cultured macrophages: A potential formulation for treatment of oral aphthous stomatitis
( Elsevier , 2023 , Article)Oral aphthous stomatitis is a common disorder treated with the immunomodulatory drug Amlexanox (AMX), that was administered as a mucoadhesive paste (Aphthasol®). This product was discontinued by FDA in 2014 due to the ... -
Anticancer drug delivery: Investigating the impacts of viscosity on lipid-based formulations for pulmonary targeting
( Elsevier , 2024 , Article)Pulmonary drug delivery via aerosolization is a non-intrusive method for achieving localized and systemic effects. The aim of this study was to establish the impact of viscosity as a novel aspect (i.e., low, medium and ... -
Carbon nanotubes: Applications in cancer therapy and drug delivery research
( Elsevier , 2018 , Book chapter)Carbon nanotubes (CNTs) are novel nanocarrier systems that have a wide range of applications in science, engineering, and, the environment. Owing to the possible functionalization of CNTs (i.e., surface-engineering of the ... -
Chemically modified mRNA beyond COVID-19: Potential preventive and therapeutic applications for targeting chronic diseases
( Elsevier , 2022 , Article Review)Chemically modified mRNA represents a unique, efficient, and straightforward approach to produce a class of biopharmaceutical agents. It has been already approved as a vaccination-based method for targeting SARS-CoV-2 ... -
Cyclodextrin diethyldithiocarbamate copper ii inclusion complexes: A promising chemotherapeutic delivery system against chemoresistant triple negative breast cancer cell lines
( MDPI AG , 2021 , Article)Diethyldithiocarbamate Copper II (DDC-Cu) has shown potent anticancer activity against a wide range of cancer cells, but further investigations are hindered by its practical insolubility in water. In this study, inclusion ... -
Delivery of anticancer molecules using carbon nanotubes
( Springer International Publishing , 2016 , Book chapter)Since their discovery in 1991, carbon nanotubes (CNTs) have emerged as material structures with numerous potential applications with a number of products already in the market place. An exciting application, which is ... -
Design characteristics of inhaler devices used for pulmonary delivery of medical aerosols
( Springer International Publishing , 2016 , Book chapter)For the treatment of respiratory diseases, it is vital to deliver therapeutic doses of drugs to specific regions in the tracheobronchial tree (TBT) of the lung with maximal efficiency and minimal wastage of medication. ... -
Development and Characterization of Novel Combinations and Compositions of Nanostructured Lipid Carrier Formulations Loaded with Trans-Resveratrol for Pulmonary Drug Delivery
( MDPI , 2024 , Article)Background/Objectives: This study aimed to fabricate, optimize, and characterize nanostructured lipid carriers (NLCs) loaded with trans-resveratrol (TRES) as an anti-cancer drug for pulmonary drug delivery using medical ... -
Editorial: Anti-cancer drug delivery: lipid-based nanoparticles
( Frontiers Media SA , 2023 , Article)Cancer continues to pose significant challenges that require extensive attention and efforts from the scientific community. The battle against cancer encompasses the development of effective and safe therapeutic approaches. ... -
Efficient design to fabricate smart Lumefantrine nanocrystals using DENA® particle engineering technology: Characterisation, in vitro and in vivo antimalarial evaluation and assessment of acute and sub-acute toxicity
( Elsevier , 2020 , Article)Nanocrystalization technologies have a great potential to substantially increase solubility as well as alleviate the erratic bioavailability behaviour of a range of poorly water soluble drugs. The aim of the current study ... -
Enhancement in Oral Absorption of Ceftriaxone by Highly Functionalized Magnetic Iron Oxide Nanoparticles.
( MDPI , 2020 , Article)The present study aims at the development, characterization, biocompatibility investigation and oral bioavailability evaluation of ceftriaxone (CFT)-loaded N'-methacryloylisonicotinohydrazide (MIH)-functionalized magnetic ... -
Enhancing gliclazide solubility using solid dispersions with carboxymethyl chitosan and polyvinylpyrrolidone K30 as polymeric carriers
( Taylor and Francis , 2025 , Article)Background: Gliclazide (Glz) is a second-generation sulfonylurea antidiabetic drug, used to treat type II diabetes mellitus. Glz is a class II drug according to the biopharmaceutic classification system (BCS), indicating ... -
Fabrication of hesperidin hybrid lecithin-folic acid silver nanoparticles and its evaluation as anti-arthritis formulation in autoimmune arthritic rat model.
( Elsevier , 2023 , Article)Rheumatoid arthritis (RA) is an immune-mediated inflammatory disease that results in synovitis, cartilage destruction and loss of joint function. The frequent and long-term administration of anti-rheumatic drugs often leads ... -
Fabrication, characterization and optimization of nanostructured lipid carrier formulations using Beclomethasone dipropionate for pulmonary drug delivery via medical nebulizers
( Elsevier , 2021 , Article)Aerosolization is a non-invasive approach in drug delivery for localized and systemic effect. Nanostructured lipid carriers (NLCs) are new generation versatile carriers, which offer protection from degradation and enhance ... -
A Facile and Novel Approach to Manufacture Paclitaxel-Loaded Proliposome Tablet Formulations of Micro or Nano Vesicles for Nebulization
( Springer , 2020 , Article)© 2020, The Author(s). Purpose: The aim of this study was to develop novel paclitaxel-loaded proliposome tablet formulations for pulmonary drug delivery. Method: Proliposome powder formulations (i.e. F1 – F27) were prepared ... -
Galactosylated iron oxide nanoparticles for enhancing oral bioavailability of ceftriaxone
( Taylor and Francis Ltd. , 2021 , Article)The current study focuses on the development, characterization, biocompatibility investigation and oral bioavailability evaluation of ceftriaxone (CFT)-loaded lactobionic acid (LBA)-functionalized iron oxide magnetic ... -
Guiding Factors and Surface Modification Strategies for Biomaterials in Pharmaceutical Product Development
( Elsevier , 2019 , Book chapter)With the technological advent in the field of drug delivery and medicines, biomaterials become important owing to their properties such as biocompatibility, functionality, and bioactive and bioinert nature. However, the ... -
Impact of dispersion media and carrier type on spray-dried proliposome powder formulations loaded with beclomethasone dipropionate for their pulmonary drug delivery via a next generation impactor
( Public Library of Science , 2023 , Article)Drug delivery via aerosolization for localized and systemic effect is a non-invasive approach to achieving pulmonary targeting. The aim of this study was to prepare spray-dried proliposome (SDP) powder formulations to ... -
Impact of nanosizing on the formation and characteristics of polymethacrylate films: micro- versus nano-suspensions
( Taylor and Francis Ltd. , 2021 , Article)Aqueous-based film coating suspensions are associated with reliance on alkalinising reagents and poor film formation. The impact of particle size in this process and resultant film properties remains unclear. This study ...
