تصفح حسب المؤلف "Buntwal, Luke"
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Calmodulin Interacts and Regulates Enzyme Activity of the Mammalian Sperm Phospholipase C
Nomikos, Michail; Thanassoulas, Angelos; L. Calver, Brian; Theodoridou, Maria; Buntwal, Luke; Sideratou, Zili; Nounesis, George; Lai, F. Anthony... more authors ... less authors ( Elsevier , 2017 , Article)Sperm-specific Phospholipase C zeta (PLCζ) is widely considered to be the sole, physiological stimulus responsible for the generation of Ca2+ oscillations that induce egg activation and early embryo development during ... -
Calmodulin Mutations Associated with Congenital Cardiac Disease Display Novel Biophysical and Biochemical Characteristics
Nomikos, Michail; Thanassoulas, Angelos; L. Calver, Brian; Beck, Konrad; Vassilakopoulou, Vyronia; Buntwal, Luke; Konotgianni, Iris; Smith, Adrian; Safieh-Garabedian, Bared; Livaniou, Evangelia; Steen Toft, Egon; Nounesis, George... more authors ... less authors ( Elsevier , 2018 , Article)Calmodulin (CaM) is a cytoplasmic multifunctional calcium (Ca2+)-binding messenger that interacts with the cardiac ryanodine receptor (RyR2), a large transmembrane Ca2+ channel that mediates Ca2+ release from the sarcoplasmic ... -
Life-threatening arrhythmogenic CaM mutations disrupt CaM binding to a distinct RyR2 CaM-binding pocket
Angelos, Thanassoulas; Vassilakopoulou, Vyronia; Calver, Brian L.; Buntwal, Luke; Smith, Adrian; Lai, Christopher; Kontogianni, Iris; Livaniou, Evangelia; Nounesis, George; Lai, F. Anthony; Nomikos, Michail... more authors ... less authors ( Elsevier , 2023 , Article)Calmodulin (CaM) modulates the activity of several proteins that play a key role in excitation-contraction coupling (ECC). In cardiac muscle, the major binding partner of CaM is the type-2 ryanodine receptor (RyR2) and ... -
Male infertility-linked point mutation reveals a vital binding role for the C2 domain of sperm PLC?
Nomikos, Michail; Stamatiadis, Panagiotis; Sanders, Jessica R.; Beck, Konrad; Calver, Brian L.; Buntwal, Luke; Lofty, Morgan; Sideratou, Zili; Swann, Karl; Lai, F. Anthony... more authors ... less authors ( Portland Press Ltd , 2017 , Article)Sperm-specific phospholipase C zeta (PLC?) is widely considered to be the physiological stimulus that evokes intracellular calcium (Ca2+) oscillations that are essential for the initiation of egg activation during mammalian ...