Browsing by Author "Dermime, Said"
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Applications of polydopaminic nanomaterials in mucosal drug delivery
Takwa, Bedhiafi; Idoudi, Sourour; Alhams, Areej Ali; Fernandes, Queenie; Iqbal, Heba; Basineni, Renuka; Uddin, Shahab; Dermime, Said; Merhi, Maysaloun; Billa, Nashiru... more authors ... less authors ( Elsevier , 2023 , Article Review)Polydopamine (PDA) is a biopolymer with unique physicochemical properties, including free-radical scavenging, high photothermal conversion efficiency, biocompatibility, biodegradability, excellent fluorescent and theranostic ... -
Circulating exosomal immuno-oncological checkpoints and cytokines are potential biomarkers to monitor tumor response to anti-PD-1/PD-L1 therapy in non-small cell lung cancer patients
Akbar, Shayista; Raza, Afsheen; Mohsin, Reyad; Kanbour, Aladdin; Qadri, Shahnaz; Parray, Aijaz; Zar Gul, Abdul Rehman; Philip, Anite; Vijayakumar, Suma; Merhi, Maysaloun; Hydrose, Shereena; Inchakalody, Varghese Philipose; Al-Abdulla, Rajaa; Abualainin, Wafa; Sirriya, Shaza Abu; Al-Bozom, Issam; Uddin, Shahab; Khan, Omar Muhammad; Mohamed Ibrahim, Mohamed Izham; Al Homsi, Ussama; Dermime, Said... more authors ... less authors ( Frontiers Media S.A. , 2023 , Article)Immune checkpoint inhibitors (ICIs) including anti-PD-1 and anti-PD-L1 antibodies, have significantly changed the treatment outcomes of NSCLC patients with better overall survival. However, 15-40% of the patients still ... -
Decoding the functional role of extracellular vesicles in hepatocellular carcinoma: implications in clinical theranostics
Kalyani, Patil; Dermime, Said; Uddin, Shahab ( Elsevier , 2022 , Book chapter)Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer in adults, the sixth most commonly diagnosed neoplasia, and the third leading cause of cancer-related deaths worldwide. Despite tangible ... -
Emerging COVID-19 variants and their impact on SARS-CoV-2 diagnosis, therapeutics and vaccines
Fernandes, Queenie; Inchakalody, Varghese Philipose; Merhi, Maysaloun; Mestiri, Sarra; Taib, Nassiba; Moustafa Abo El-Ella, Dina; Bedhiafi, Takwa; Raza, Afsheen; Al-Zaidan, Lobna; Mohsen, Mona O.; Yousuf Al-Nesf, Mariam Ali; Hssain, Ali Ait; Yassine, Hadi Mohamad; Bachmann, Martin F.; Uddin, Shahab; Dermime, Said... more authors ... less authors ( Taylor and Francis , 2022 , Article)The emergence of novel and evolving variants of SARS-CoV-2 has fostered the need for change in the form of newer and more adaptive diagnostic methods for the detection of SARS-CoV-2 infections. On the other hand, developing ... -
Epigenetic and breast cancer therapy: Promising diagnostic and therapeutic applications.
Sher, Gulab; Salman, Nadia Aziz; Khan, Abdul Q; Prabhu, Kirti S; Raza, Afsheen; Kulinski, Michal; Dermime, Said; Haris, Mohammad; Junejo, Kulsoom; Uddin, Shahab... more authors ... less authors ( Elsevier , 2020 , Article Review)The global burden of breast cancer (BC) is increasing significantly. This trend is caused by several factors such as late diagnosis, limited treatment options for certain BC subtypes, drug resistance which all lead to poor ... -
Guggulsterone Induces Apoptosis in Multiple Myeloma Cells by Targeting High Mobility Group Box 1 via Janus Activated Kinase/Signal Transducer and Activator of Transcription Pathway
Akhtar, Sabah; Zarif, Lubna; Kuttikrishnan, Shilpa; Prabhu, Kirti S.; Patil, Kalyani; Nisar, Sabah; Abou-Saleh, Haissam; Merhi, Maysaloun; Dermime, Said; Bhat, Ajaz A.; Uddin, Shahab... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)Multiple myeloma (MM) is a hematological disorder characterized by the abnormal expansion of plasma cells in the bone marrow. Despite great advances over the past three decades in discovering the efficacious therapies for ... -
Nano-vitamin C: A promising candidate for therapeutic applications
Bedhiafi, Takwa; Idoudi, Sourour; Fernandes, Queenie; Al-Zaidan, Lobna; Uddin, Shahab; Dermime, Said; Billa, Nashiru; Merhi, Maysaloun... more authors ... less authors ( Elsevier , 2023 , Article Review)Vitamin C is an important nutrient implicated in different physiological functions in humans. Despite its important biological functions, therapeutic applications of vitamin C are rare and its use is further impacted by ... -
Neutralization of MERS coronavirus through a scalable nanoparticle vaccine
Mohsen, Mona O; Rothen, Dominik; Balke, Ina; Martina, Byron; Zeltina, Vilija; Inchakalody, Varghese; Gharailoo, Zahra; Nasrallah, Gheyath; Dermime, Said; Tars, Kaspars; Vogel, Monique; Zeltins, Andris; Bachmann, Martin F... more authors ... less authors ( Springer Nature , 2021 , Article)MERS-CoV continues to cause human outbreaks, so far in 27 countries worldwide following the first registered epidemic in Saudi Arabia in 2012. In this study, we produced a nanovaccine based on virus-like particles (VLPs). ... -
A novel approach of encapsulating curcumin and succinylated derivative in mannosylated-chitosan nanoparticles
Idoudi, Sourour; Hijji, Yousef; Bedhiafi, Takwa; Korashy, Hesham M.; Uddin, Shahab; Merhi, Maysaloun; Dermime, Said; Billa, Nashiru... more authors ... less authors ( Elsevier , 2022 , Article)Curcumin (CUR) manifests anti-colon cancer activity but suffers from low solubility, bioavailability, and instability, rendering it not as effective as its chemotherapeutic cousins. Here, we conjugate CUR to succinic ... -
Persistence of spike-specific immune responses in BNT162b2-vaccinated donors and generation of rapid ex-vivo T cells expansion protocol for adoptive immunotherapy: A pilot study
Mestiri, Sarra; Merhi, Maysaloun; Inchakalody, Varghese P.; Taib, Nassiba; Smatti, Maria K.; Ahmad, Fareed; Raza, Afsheen; Ali, Fatma H.; Hydrose, Shereena; Fernandes, Queenie; Ansari, Abdul W.; Sahir, Fairooz; Al-Zaidan, Lobna; Jalis, Munir; Ghoul, Mokhtar; Allahverdi, Niloofar; Al Homsi, Mohammed U.; Uddin, Shahab; Jeremijenko, Andrew Martin; Nimir, Mai; Abu-Raddad, Laith J.; Abid, Fatma Ben; Zaqout, Ahmed; Alfheid, Sameer R.; Saqr, Hassan Mohamed Hassan; Omrani, Ali S.; Hssain, Ali Ait; Al Maslamani, Muna; Yassine, Hadi M.; Dermime, Said... more authors ... less authors ( Frontiers Media , 2023 , Article)Introduction: The BNT162b2 mRNA-based vaccine has shown high efficacy in preventing COVID-19 infection but there are limited data on the types and persistence of the humoral and T cell responses to such a vaccine. Methods: ... -
The potential role of vitamin C in empowering cancer immunotherapy
Takwa, Bedhiafi; Inchakalody, Varghese Philipose; Fernandes, Queenie; Mestiri, Sarra; Billa, Nashiru; Uddin, Shahab; Merhi, Maysaloun; Dermime, Said... more authors ... less authors ( Elsevier , 2022 , Article)Vitamin C also known as L-ascorbic acid is a nutrient naturally occurring in many fruits and vegetables and widely known for its potent antioxidant activity. Several studies have highlighted the importance of using high ... -
RAS-mediated oncogenic signaling pathways in human malignancies
Khan, Abdul Q.; Kuttikrishnan, Shilpa; Kodappully S., Siveen; Kirti S., Prabhu; Shanmugakonar, Muralitharan; Al- Naemi, Hamda A.; Haris, Mohammad; Dermime, Said; Uddin, Shahab... more authors ... less authors ( Elsevier , 2018 , Article Review)Abnormally activated RAS proteins are the main oncogenic driver that governs the functioning of major signaling pathways involved in the initiation and development of human malignancies. Mutations in RAS genes and or its ... -
The Role of Extracellular Vesicles as Modulators of the Tumor Microenvironment, Metastasis and Drug Resistance in Colorectal Cancer.
Siveen, Kodappully S; Raza, Afsheen; Ahmed, Eiman I; Khan, Abdul Q; Prabhu, Kirti S; Kuttikrishnan, Shilpa; Mateo, Jericha M; Zayed, Hatem; Rasul, Kakil; Azizi, Fouad; Dermime, Said; Steinhoff, Martin; Uddin, Shahab... more authors ... less authors ( MDPI , 2019 , Article)Colorectal cancer (CRC) is one of the most common cancers worldwide, with high morbidity and mortality rates. A number of factors including modulation of the tumor microenvironment, high metastatic capability, and resistance ... -
Role of HMGB1 and its associated signaling pathways in human malignancies
Sourour, Idoudi; Bedhiafi, Takwa; Pedersen, Shona; Elahtem, Mohamed; Alremawi, Izzaldin; Akhtar, Sabah; Dermime, Said; Merhi, Maysaloun; Uddin, Shahab... more authors ... less authors ( Elsevier , 2023 , Article)The High-Mobility Group Box-1 (HMGB1), a non-histone chromatin-associated protein, plays a crucial role in cancer growth and response to therapy as it retains a pivotal role in promoting both cell death and survival. HMGB1 ... -
Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling.
Akhtar, Sabah; Achkar, Iman W; Siveen, Kodappully S; Kuttikrishnan, Shilpa; Prabhu, Kirti S; Khan, Abdul Q; Ahmed, Eiman I; Sahir, Fairooz; Jerobin, Jayakumar; Raza, Afsheen; Merhi, Maysaloun; Elsabah, Hesham M; Taha, Ruba; Omri, Halima El; Zayed, Hatem; Dermime, Said; Steinhoff, Martin; Uddin, Shahab... more authors ... less authors ( Frontiers Media , 2019 , Article)Sanguinarine (SNG), a benzophenanthridine alkaloid, has displayed various anticancer abilities in several vivo and studies. However, the anticancer potential of SNG is yet to be established in multiple myeloma (MM), a ... -
Sanguinarine mediated apoptosis in Non-Small Cell Lung Cancer via generation of reactive oxygen species and suppression of JAK/STAT pathway
Kirti.S., Prabhu; Bhat, Ajaz A.; Siveen, Kodappully S.; Kuttikrishnan, Shilpa; Raza, Syed Shadab; Raheed, Thesni; Jochebeth, Anh; Khan, Abdul Q.; Chawdhery, M.Zafar; Haris, Mohammad; Kulinski, Michal; Dermime, Said; Steinhoff, Martin; Uddin, Shahab... more authors ... less authors ( Elsevier , 2021 , Article)Effective treatment of lung cancer remains a significant clinical challenge due to its multidrug resistance and side effects of the current treatment options. The high mortality associated with this malignancy indicates ... -
Studies on anti-colon cancer potential of nanoformulations of curcumin and succinylated curcumin in mannosylated chitosan
Sourour, Idoudi; Bedhiafi, Takwa; Sahir, Fairooz; Hijji, Yousef; Uddin, Shahab; Merhi, Maysaloun; Dermime, Said; Billa, Nashiru... more authors ... less authors ( Elsevier , 2023 , Article)Colon cancer (CRC) is the second leading cause of death and the third most diagnosed cancer worldwide. Although curcumin (CUR) has demonstrated a potent anticancer activity, it is characterized by its poor solubility, low ... -
Treatment with decitabine induces the expression of stemness markers, PD-L1 and NY-ESO-1 in colorectal cancer: potential for combined chemoimmunotherapy
Taib, Nassiba; Merhi, Maysaloun; Inchakalody, Varghese; Mestiri, Sarra; Hydrose, Shereena; Makni-Maalej, Karama; Raza, Afsheen; Sahir, Fairooz; Azizi, Fouad; Nizamuddin, Parveen B.; Fernandes, Queenie; Yoosuf, Zeenath Safira K. M.; Almoghrabi, Salam; Al-Zaidan, Lobna; Shablak, Alaaeldin; Uddin, Shahab; Maccalli, Cristina; Al Homsi, Mohammed Ussama; Dermime, Said... more authors ... less authors ( BioMed Central Ltd , 2023 , Article)Background: The mechanism of tumor immune escape and progression in colorectal cancer (CRC) is widely investigated in-vitro to help understand and identify agents that might play a crucial role in response to treatment and ... -
Vascular endothelial growth factor (VEGF) signaling in tumour vascularization: Potential and challenges
Siveen, Kodappully Sivaraman; Prabhu, Kirti; Krishnankutty, Roopesh; Kuttikrishnan, Shilpa; Tsakou, Magdalini; Alali, Feras Q.; Dermime, Said; Mohammad, Ramzi M.; Uddin, Shahab... more authors ... less authors ( Bentham , 2017 , Article)Angiogenesis is defined as the physiological process by which new blood vessels develop from pre-existing vessels; either by sprouting or intussusception. Inhibition of angiogenesis is one of the most encouraging strategies ...