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    Applications of polydopaminic nanomaterials in mucosal drug delivery

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    1-s2.0-S0168365922008501-main.pdf (3.884Mb)
    Date
    2023-01-31
    Author
    Takwa, Bedhiafi
    Idoudi, Sourour
    Alhams, Areej Ali
    Fernandes, Queenie
    Iqbal, Heba
    Basineni, Renuka
    Uddin, Shahab
    Dermime, Said
    Merhi, Maysaloun
    Billa, Nashiru
    ...show more authors ...show less authors
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    Abstract
    Polydopamine (PDA) is a biopolymer with unique physicochemical properties, including free-radical scavenging, high photothermal conversion efficiency, biocompatibility, biodegradability, excellent fluorescent and theranostic capacity due to their abundant surface chemistry. Thus, PDA is used for a myriad of applications including drug delivery, biosensing, imaging and cancer therapy. Recent reports present a new functionality of PDA as a coating nanomaterial, with major implications in mucosal drug delivery applications, particularly muco-adhesion and muco-penetration. However, this application has received minimal traction in the literature. In this review, we present the physicochemical and functional properties of PDA and highlight its key biomedical applications, especially in cancer therapy. A detailed presentation of the role of PDA as a promising coating material for nanoparticulate carriers intended for mucosal delivery forms the core aspect of the review. Finally, a reflection on key considerations and challenges in the utilizing PDA for mucosal drug delivery, along with the possibilities of translation to clinical studies is expounded.
    URI
    https://www.sciencedirect.com/science/article/pii/S0168365922008501
    DOI/handle
    http://dx.doi.org/10.1016/j.jconrel.2022.12.037
    http://hdl.handle.net/10576/44630
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    • Laboratory Animal Research Center (Research) [‎129‎ items ]
    • Medicine Research [‎1755‎ items ]
    • Pharmacy Research [‎1399‎ items ]

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