تصفح حسب المؤلف "Almajali, Belal"
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Gene Expression Profiling and Protein Analysis Reveal Suppression of the C-Myc Oncogene and Inhibition JAK/STAT and PI3K/AKT/mTOR Signaling by Thymoquinone in Acute Myeloid Leukemia Cells
Almajali, Belal; Johan, Muhammad Farid; Al-Wajeeh, Abdullah Saleh; Wan Taib, Wan Rohani; Ismail, Imilia; Alhawamdeh, Maysa; Al-Tawarah, Nafe M.; Ibrahim, Wisam Nabeel; Al-Rawashde, Futoon Abedrabbu; Al-Jamal, Hamid Ali Nagi... more authors ... less authors ( MDPI , 2022 , Article)Overexpression of c-Myc plays an essential role in leukemogenesis and drug resistance, making c-Myc an attractive target for cancer therapy. However, targeting c-Myc directly is impossible, and c-Myc upstream regulator ... -
Thymoquinone Suppresses Cell Proliferation and Enhances Apoptosis of HL60 Leukemia Cells through Re-Expression of JAK/STAT Negative Regulators.
Almajali, Belal; Al-Jamal, Hamid Ali Nagi; Wan Taib, Wan Rohani; Ismail, Imilia; Johan, Muhammad Farid; Doolaanea, Abd Almonem; Ibrahim, Wisam Nabeel; Tajudin, Syed Ahmad... more authors ... less authors ( West Asia Organization for Cancer Prevention (WAOCP) , 2021 , Article)The natural compound, thymoquinone (TQ) has demonstrated potential anticancer properties in inhibiting cell proliferation and promoting apoptosis in myeloid leukemia cells, breast cancer cells, and others. However, the ... -
Thymoquinone, as a Novel Therapeutic Candidate of Cancers
Almajali, Belal; Nagi, Hamid Ali; Taib, Wan Rohani Wan; Ismail, Imilia Ismail; Johan, Muhammad Farid; Doolaanea, Abd Almonem; Ibrahim, Wisam Nabeel... more authors ... less authors ( MDPI , 2021 , Article)To date, natural products are widely used as pharmaceutical agents for many human diseases and cancers. One of the most popular natural products that have been studied for anticancer properties is thymoquinone (TQ). As ...