Browsing by Author "Zayed, Hatem"
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A review of bioinformatics tools and web servers in different microarray platforms used in cancer research
Hephzibah Cathryn, R.; Udhaya Kumar, S.; Younes, Salma; Zayed, Hatem; George Priya Doss, C. ( Elsevier , 2022 , Book chapter)Over the past decade, conventional lab work strategies have gradually shifted from being limited to a laboratory setting towards a bioinformatics era to help manage and process the vast amounts of data generated by omics ... -
A systemic approach to explore the mechanisms of drug resistance and altered signaling cascades in extensively drug-resistant tuberculosis
Udhaya Kumar, S.; Saleem, Aisha; Thirumal Kumar, D.; Anu Preethi, V.; Younes, Salma; Zayed, Hatem; Tayubi, Iftikhar Aslam; George Priya Doss, C.... more authors ... less authors ( Elsevier , 2021 , Book chapter)Background and aim: The persistence of extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (MTB) continue to pose a significant challenge to the treatment and control of tuberculosis infections worldwide. ... -
Aberrant DNA methylation of PTPRG as one possible mechanism of its under-expression in CML patients in the State of Qatar
Ismail, Mohamed A; Samara, Muthanna; Al Sayab, Ali; Alsharshani, Mohamed; Yassin, Mohamed A; Varadharaj, Govindarajulu; Vezzalini, Marzia; Tomasello, Luisa; Monne, Maria; Morsi, Hisham; Qoronfleh, M Walid; Zayed, Hatem; Cook, Richard; Sorio, Claudio; Modjtahedi, Helmout; Al-Dewik, Nader I... more authors ... less authors ( Wiley Open Access , 2020 , Article)Several studies showed that aberrant DNA methylation is involved in leukemia and cancer pathogenesis. Protein tyrosine phosphatase receptor gamma (PTPRG) expression is a natural inhibitory mechanism that is downregulated ... -
Accredited genetic testing in the Arab Gulf region: reinventing the wheel.
Zayed, Hatem; Ouhtit, Allal ( Nature Publishing Group , 2016 , Article)Accredited genetic testing in the Arab Gulf region: reinventing the wheel. -
An integrative analysis to distinguish between emphysema (EML) and alpha-1 antitrypsin deficiency-related emphysema (ADL)-A systems biology approach
Udhaya Kumar, S.; Madhana Priya, N.; Thirumal Kumar, D.; Anu Preethi, V.; Kumar, Vibhaa; Nagarajan, Dhanushya; Magesh, R.; Younes, Salma; Zayed, Hatem; George Priya Doss, C.... more authors ... less authors ( Elsevier , 2021 , Book chapter)Lung Emphysema is an abnormal enlargement of the air sacs followed by the destruction of alveolar walls without any prominent fibrosis. This study primarily identifies the differentially expressed genes (DEGs), interactions ... -
An updated overview of cyanidins for chemoprevention and cancer therapy
Posadino, Anna Maria; Giordo, Roberta; Ramli, Iman; Zayed, Hatem; Nasrallah, Gheyath K.; Wehbe, Zena; Eid, Ali H.; Gürer, Eda Sönmez; Kennedy, John F.; Aldahish, Afaf Ahmed; Calina, Daniela; Razis, Ahmad Faizal Abdull; Modu, Babagana; Habtemariam, Solomon; Sharifi-Rad, Javad; Pintus, Gianfranco; Cho, William C.... more authors ... less authors ( Elsevier , 2023 , Article Review)Anthocyanins are colored polyphenolic compounds that belong to the flavonoids family and are largely present in many vegetables and fruits. They have been used in traditional medicine in many cultures for a long time. The ... -
Analysis of Differentially Expressed Genes and Molecular Pathways in Familial Hypercholesterolemia Involved in Atherosclerosis: A Systematic and Bioinformatics Approach.
Udhaya Kumar, S; Thirumal Kumar, D; Bithia, R; Sankar, Srivarshini; Magesh, R.; Sidenna, Mariem; George Priya Doss, C; Zayed, Hatem... more authors ... less authors ( Frontiers Media , 2020 , Article)Familial hypercholesterolemia (FH) is one of the major risk factor for the progression of atherosclerosis and coronary artery disease. This study focused on identifying the dysregulated molecular pathways and core genes ... -
Analysis of signaling cascades from myeloma cells treated with pristimerin
Almaghrbi, Heba; Elkardawy, Rehab; Kumar. S, Udhaya; Kuttikrishnan, Shilpa; Abunada, Taghreed; Kashyap, Manoj Kumar; Ahmad, Aamir; Uddin, Shahab; Doss. C, George Priya; Zayed, Hatem... more authors ... less authors ( Elsevier , 2022 , Book chapter)Multiple myeloma (MM) is the 2nd most frequently diagnosed blood cancer after non-Hodgkin's lymphoma. The present study aimed to identify the differentially expressed genes (DEGs) between the control and pristimerin-treated ... -
Anaphylaxis triggers in a large tertiary care hospital in Qatar: a retrospective study
Abunada, Taghreed; Al-Nesf, Maryam Ali; Thalib, Lukman; Kurdi, Rana; Khalil, Sally; ElKassem, Wessam; Mobayed, Hassan M; Zayed, Hatem... more authors ... less authors ( BMC , 2018 , Article)Anaphylaxis is a serious allergic disease that may lead to death if not immediately recognized and treated. Triggers of anaphylaxis including food, drugs, and insect stings can vary widely. The incidence of anaphylaxis ... -
Anticancer Activity of Guggulsterone in Human Leukemic Cells
Younes, Salma Nagy Mahmoud Zaky (2020 , Master Thesis)Leukemia is a group of blood cancers that is characterized by the uncontrolled proliferation of hematopoietic cells and their progressive accumulation within the bone marrow (BM) and secondary lymphoid tissues. The main ... -
The Arab genome: Health and wealth
Zayed, Hatem ( Elsevier B.V. , 2016 , Article)The 22 Arab nations have a unique genetic structure, which reflects both conserved and diverse gene pools due to the prevalent endogamous and consanguineous marriage culture and the long history of admixture among different ... -
An Arab registry for type 1 diabetes: global benefits for type 1 diabetes patients
Zayed, Hatem; Ouhtit, Allal; El Bekay, Rajaa ( Taylor & Francis , 2016 , Article)BACKGROUND: The Arab world encompasses twenty-two Arabic-speaking countries, where the rate of consanguinity can exceed 50%. Type 1 diabetes (T1D), a chronic disorder that requires lifelong treatment, is believed to be ... -
Association between Soft Drink Consumption and Aggressive Behaviour among a Quarter Million Adolescents from 64 Countries Based on the Global School-Based Student Health Survey (GSHS)
Shi, Zumin; Malki, Ahmed; Abdel-Salam, Abdel-Salam; Liu, Jianghong; Zayed, Hatem ( MDPI , 2020 , Article)Soft drink consumption has become a significant public health concern that is associated with various adverse health outcomes.We aim to examine the association between soft drink consumption and aggressive behavior among ... -
Association of genetic variants with colorectal cancer in the extended MENA region: A systematic review
Sidenna, Mariem; Bux, Reem; Fadl, Tasnim; Ozbek, Ugur; Zayed, Hatem ( Bentham Science Publishers , 2019 , Article)Colorectal cancer (CRC) is the third most common cancer worldwide and the third leading cause of cancer-related death. It is a heterogeneous disease that develops through different genetic and epigenetic mechanisms. To ... -
Association of single nucleotide polymorphisms with dyslipidemia and risk of metabolic disorders in the State of Qatar
Al-Sharshani, Dalal; Velayutham, Dinesh; Samara, Muthanna; Gazal, Reham; Al Haj Zen, Ayman; Ismail, Mohamed A.; Ahmed, Mahmoud; Nasrallah, Gheyath; Younes, Salma; Rizk, Nasser; Hammuda, Sara; Qoronfleh, M. Walid; Farrell, Thomas; Zayed, Hatem; Abdulrouf, Palli Valapila; AlDweik, Manar; Silang, John Paul Ben; Rahhal, Alaa; Al-Jurf, Rana; Mahfouz, Ahmed; Salam, Amar; Al Rifai, Hilal; Al-Dewik, Nader I.... more authors ... less authors ( Wiley-Blackwell , 2023 , Article)Background: Dyslipidemia is recognized as one of the risk factors of cardiovascular diseases (CVDs), type 2 diabetes mellitus (T2DM), and non-alcoholic fatty liver disease (NAFLD). Objective: The study aimed to investigate ... -
Bioinformatics classification of mutations in patients with Mucopolysaccharidosis IIIA
Tanwar, Himani; Kumar, D Thirumal; Doss, C George Priya; Zayed, Hatem ( Springer US , 2019 , Article)Mucopolysaccharidosis (MPS) IIIA, also known as Sanfilippo syndrome type A, is a severe, progressive disease that affects the central nervous system (CNS). MPS IIIA is inherited in an autosomal recessive manner and is ... -
Bioinformatics investigation on blood-based gene expressions of Alzheimer's disease revealed ORAI2 gene biomarker susceptibility: An explainable artificial intelligence-based approach
Sekaran, Karthik; Alsamman, Alsamman M.; George Priya Doss, C.; Zayed, Hatem ( Springer , 2023 , Article)The progressive, chronic nature of Alzheimer's disease (AD), a form of dementia, defaces the adulthood of elderly individuals. The pathogenesis of the condition is primarily unascertained, turning the treatment efficacy ... -
Bladder neoplasms and NF-κB: an unfathomed association.
Jebaraj Walter, Charles Emmanuel; Durairajan, Sankari; Periyandavan, Kalaiselvi; Priya Doss C, George; Davis G, Dicky John; Vasanthi A, Hannah Rachel; Johnson, Thanka; Zayed, Hatem... more authors ... less authors ( Taylor & Francis , 2020 , Article)Bladder cancer is the second most common genitourinary tract cancer and is often recurrent and/or chemoresistant after tumor resection. Cigarette smoking, exposure to aromatic amines, and chronic infection/inflammation are ... -
Breast cancer in the GCC countries: A focus on BRCA1/2 and non-BRCA1/2 genes.
Rahman, Sumaya; Zayed, Hatem ( Elsevier , 2018 , Article)The GCC is an economic alliance of six Arab countries, including Bahrain, Kuwait, Oman, Qatar, Saudi Arabia, and United Arab Emirates (UAE). The rate of endogamous marriage among the GCC countries is approaching 100%, with ... -
Canavan disease: an Arab scenario.
Zayed, Hatem ( Elsevier Inc. , 2015 , Article)The autosomal recessive Canavan disease (CD) is a neurological disorder that begins in infancy. CD is caused by mutations in the gene encoding the ASPA enzyme. It has been reported with high frequency in patients with ...