Browsing by Author "Zayed, Hatem"
Now showing items 1-20 of 168
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A new horizon in the phosphorylated sites of AGA: the structural impact of C163S mutation in aspartylglucosaminuria through molecular dynamics simulation
( Taylor and Francis Ltd. , 2023 , Article)Aspartylglucosaminuria (AGU) is a lysosomal storage disorder caused by insufficient aspartylglucosaminidase (AGA) activity leading to chronic neurodegeneration. We utilized the PhosphoSitePlus tool to identify the AGA ... -
A review of bioinformatics tools and web servers in different microarray platforms used in cancer research
( Elsevier , 2022 , Book chapter)Over the past decade, conventional lab work strategies have gradually shifted from being limited to a laboratory setting towards a bioinformatics era to help manage and process the vast amounts of data generated by omics ... -
A systemic approach to explore the mechanisms of drug resistance and altered signaling cascades in extensively drug-resistant tuberculosis
( Elsevier , 2021 , Book chapter)Background and aim: The persistence of extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (MTB) continue to pose a significant challenge to the treatment and control of tuberculosis infections worldwide. ... -
Aberrant DNA methylation of PTPRG as one possible mechanism of its under-expression in CML patients in the State of Qatar
( Wiley Open Access , 2020 , Article)Several studies showed that aberrant DNA methylation is involved in leukemia and cancer pathogenesis. Protein tyrosine phosphatase receptor gamma (PTPRG) expression is a natural inhibitory mechanism that is downregulated ... -
Accredited genetic testing in the Arab Gulf region: reinventing the wheel.
( Nature Publishing Group , 2016 , Article)Accredited genetic testing in the Arab Gulf region: reinventing the wheel. -
Airway and Oral microbiome profiling of SARS-CoV-2 infected asthma and non-asthma cases revealing alterations-A pulmonary microbial investigation
( NLM (Medline) , 2023 , Article)New evidence strongly discloses the pathogenesis of host-associated microbiomes in respiratory diseases. The microbiome dysbiosis modulates the lung's behavior and deteriorates the respiratory system's effective functioning. ... -
An integrative analysis to distinguish between emphysema (EML) and alpha-1 antitrypsin deficiency-related emphysema (ADL)-A systems biology approach
( Elsevier , 2021 , Book chapter)Lung Emphysema is an abnormal enlargement of the air sacs followed by the destruction of alveolar walls without any prominent fibrosis. This study primarily identifies the differentially expressed genes (DEGs), interactions ... -
An updated overview of cyanidins for chemoprevention and cancer therapy
( Elsevier , 2023 , Article Review)Anthocyanins are colored polyphenolic compounds that belong to the flavonoids family and are largely present in many vegetables and fruits. They have been used in traditional medicine in many cultures for a long time. The ... -
Analysis of Differentially Expressed Genes and Molecular Pathways in Familial Hypercholesterolemia Involved in Atherosclerosis: A Systematic and Bioinformatics Approach.
( Frontiers Media , 2020 , Article)Familial hypercholesterolemia (FH) is one of the major risk factor for the progression of atherosclerosis and coronary artery disease. This study focused on identifying the dysregulated molecular pathways and core genes ... -
Analysis of signaling cascades from myeloma cells treated with pristimerin
( Elsevier , 2022 , Book chapter)Multiple myeloma (MM) is the 2nd most frequently diagnosed blood cancer after non-Hodgkin's lymphoma. The present study aimed to identify the differentially expressed genes (DEGs) between the control and pristimerin-treated ... -
Anaphylaxis triggers in a large tertiary care hospital in Qatar: a retrospective study
( BMC , 2018 , Article)Anaphylaxis is a serious allergic disease that may lead to death if not immediately recognized and treated. Triggers of anaphylaxis including food, drugs, and insect stings can vary widely. The incidence of anaphylaxis ... -
Anticancer Activity of Guggulsterone in Human Leukemic Cells
(2020 , Master Thesis)Leukemia is a group of blood cancers that is characterized by the uncontrolled proliferation of hematopoietic cells and their progressive accumulation within the bone marrow (BM) and secondary lymphoid tissues. The main ... -
The Arab genome: Health and wealth
( Elsevier , 2016 , Article Review)The 22 Arab nations have a unique genetic structure, which reflects both conserved and diverse gene pools due to the prevalent endogamous and consanguineous marriage culture and the long history of admixture among different ... -
An Arab registry for type 1 diabetes: global benefits for type 1 diabetes patients
( Taylor & Francis , 2016 , Article)BACKGROUND: The Arab world encompasses twenty-two Arabic-speaking countries, where the rate of consanguinity can exceed 50%. Type 1 diabetes (T1D), a chronic disorder that requires lifelong treatment, is believed to be ... -
Artificial blood-hope and the challenges to combat tumor hypoxia for anti-cancer therapy
( Springer Science and Business Media Deutschland GmbH , 2025 , Article Review)The blood plays a vital role in the human body and serves as an intermediary between various physiological systems and organs. White blood cells, which are a part of the immune system, defend against infections and regulate ... -
Association between Soft Drink Consumption and Aggressive Behaviour among a Quarter Million Adolescents from 64 Countries Based on the Global School-Based Student Health Survey (GSHS)
( MDPI , 2020 , Article)Soft drink consumption has become a significant public health concern that is associated with various adverse health outcomes.We aim to examine the association between soft drink consumption and aggressive behavior among ... -
Association Between Vitamin D Receptor BsmI Polymorphism and Low Bone Mineral Density in Postmenopausal Women in the MENA Region
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article)Background/Objectives: Low bone mineral density increases the risk of bone fractures, and this condition is especially common in postmenopausal women. Genetic factors significantly influence bone mineral density. This ... -
Association of genetic variants with colorectal cancer in the extended MENA region: A systematic review
( Bentham Science Publishers , 2019 , Article)Colorectal cancer (CRC) is the third most common cancer worldwide and the third leading cause of cancer-related death. It is a heterogeneous disease that develops through different genetic and epigenetic mechanisms. To ... -
Association of single nucleotide polymorphisms with dyslipidemia and risk of metabolic disorders in the State of Qatar
( Wiley-Blackwell , 2023 , Article)Background: Dyslipidemia is recognized as one of the risk factors of cardiovascular diseases (CVDs), type 2 diabetes mellitus (T2DM), and non-alcoholic fatty liver disease (NAFLD). Objective: The study aimed to investigate ... -
Bioinformatics classification of mutations in patients with Mucopolysaccharidosis IIIA
( Springer US , 2019 , Article)Mucopolysaccharidosis (MPS) IIIA, also known as Sanfilippo syndrome type A, is a severe, progressive disease that affects the central nervous system (CNS). MPS IIIA is inherited in an autosomal recessive manner and is ...
