Browsing by Author "Agouni, Abdelali"
Now showing items 1-9 of 9
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Comparison of the Protective Effects of Individual Components of Particulated trans-Sialidase (PTCTS), PTC and TS, against High Cholesterol Diet-Induced Atherosclerosis in Rabbits
Garavelo, Shérrira M; Higuchi, Maria de Lourdes; Pereira, Jaqueline J; Reis, Marcia M; Kawakami, Joyce T; Ikegami, Renata N; Palomino, Suely AP; Wadt, Nilsa S Y; Agouni, Abdelali... more authors ... less authors ( Hindawi Publishing Corporation , 2017 , Article)Previous studies showed the presence of Mycoplasma pneumoniae (M. pneumoniae) and membrane-shed microparticles (MPs) in vulnerable atherosclerotic plaques. H&S Science and Biotechnology developed PTCTS, composed by natural ... -
Differentially expressed miRNA profiles of serum derived extracellular vesicles from patients with acute ischemic stroke
Ghulam, Jeelani Pir; Ammar Zahid, Muhammad; Akhtar, Naveed; Ayadathil, Raheem; Pananchikkal, Sajitha V.; Joseph, Sujata; Morgan, Deborah M.; Babu, Blessy; Ty Ui, Ryan; Sivasankaran, Shobhna; Francis, Reny; Own, Ahmed; Shuaib, Ashfaq; Parray, Aijaz; Agouni, Abdelali... more authors ... less authors ( Elsevier , 2024 , Report)BackgroundMicroRNAs (miRNAs) participate in diverse cellular changes following acute ischemic stroke (AIS). Circulating miRNAs, stabilized and delivered to target cells via extracellular vesicles (EVs), are potential ... -
In Vitro and In Vivo Validation of GATA-3 Suppression for Induction of Adipogenesis and Improving Insulin Sensitivity
Al-Jaber, Hend; Mohamed, Nura A.; Govindharajan, Vijay K.; Taha, Samir; John, Jomon; Halim, Sharique; Alser, Maha; Al-Muraikhy, Shamma; Anwardeen, Najeha Rizwana; Agouni, Abdelali; Elhissi, Abdelbary; Al-Naemi, Hamda A.; Al-Mansoori, Layla; Elrayess, Mohamed A.... more authors ... less authors ( MDPI , 2022 , Article)Impaired adipogenesis is associated with the development of insulin resistance and an increased risk of type 2 diabetes (T2D). GATA Binding Protein 3 (GATA3) is implicated in impaired adipogenesis and the onset of insulin ... -
Integrated structural proteomics and machine learning-guided mapping of a highly protective precision vaccine against mycoplasma pulmonis
Abbas, Khan; Ammar Zahid, Muhammad; Farrukh, Farheen; Salah Abdelsalam, Shahenda; Mohammad, Anwar; Al-Zoubi, Raed M.; Shkoor, Mohanad; Ait Hssain, Ali; Wei, Dong-Qing; Agouni, Abdelali... more authors ... less authors ( Elsevier , 2024 , Article)Mycoplasma pulmonis (M. pulmonis) is an emerging respiratory infection commonly linked to prostate cancer, and it is classified under the group of mycoplasmas. Improved management of mycoplasma infections is essential due ... -
Interplay between Endoplasmic Reticulum Stress and Large Extracellular Vesicles (Microparticles) in Endothelial Cell Dysfunction
Osman, Aisha; Benameur, Tarek; Korashy, Hesham M.; Zeidan, Asad; Agouni, Abdelali ( MDPI , 2020 , Article)Upon increased demand for protein synthesis, accumulation of misfolded and/or unfolded proteins within the endoplasmic reticulum (ER), a pro-survival response is activated termed unfolded protein response (UPR), aiming at ... -
Oral PTCTS (Particulated Transialidase) Removes Serum Microparticles and Decreases Inflammation in Atherosclerotic Plaques of Rabbits
Garavelo, Sherrira M.; Pereira, Jacqueline J.; Wadt, Nilsa S.Y.; Reis, Marcia M.; Ikegami, Renata N.; Kawakami, Joyce T.; Agouni, Abdelali; Palomino, Suely A.P.; Abdalla, Dulcineia; Higuchi, Maria de Lourdes... more authors ... less authors ( Scientific Research Publishing , 2015 , Article)Background: Previous studies showed that atherosclerotic plaque vulnerability was related with microparticles (MPs)-vesicles larger than 100 nm, which released MMP9 collagenase. In our pre- vious study, intramuscular ... -
Protein tyrosine phosphatase 1B inhibition improves endoplasmic reticulum stress-impaired endothelial cell angiogenic response: A critical role for cell survival
ABDELSALAM, SHAHENDA S.; PASHA, MAZHAR; EL-GAMAL, HEBA; HASAN, MARAM; ELRAYESS, MOHAMED A.; ZEIDAN, ASAD; KORASHY, HESHAM M.; AGOUNI, ABDELALI... more authors ... less authors ( Spandidos publications , 2021 , Article)Endoplasmic reticulum (ER) stress contributes to endothelial dysfunction, which is the initial step in atherogenesis. Blockade of protein tyrosine phosphatase (PTP)1B, a negative regulator of insulin receptors that is ... -
Structural proteomics guided annotation of vaccine targets and designing of multi-epitopes vaccine to instigate adaptive immune response against Francisella tularensis
Abbas, Khan; Ali, Syed Shujait; Khan, Asghar; Zahid, Muhammad Ammar; Alshabrmi, Fahad M.; Waheed, Yasir; Agouni, Abdelali... more authors ... less authors ( Elsevier , 2024 , Article)Francisella tularensis can cause severe disease in humans via the respiratory or cutaneous routes and a case fatality ratio of up to 10 % is reported due to lack of proper antibiotic treatment, while F. novicida causes ... -
Temporal cross talk between endoplasmic reticulum and mitochondria regulates oxidative stress and mediates microparticle-induced endothelial dysfunction
Safiedeen, Zainab; Rodríguez-Gómez, Isabel; Vergori, Luisa; Soleti, Raffaella; Vaithilingam, Dayannath; Douma, Imene; Agouni, Abdelali; Leiber, Denis; Dubois, Séverine; Simard, Gilles; Zibara, Kazem; Andriantsitohaina, Ramaroson; Martínez, M. Carmen... more authors ... less authors ( Mary Ann Liebert, Inc. , 2017 , Article)Aims: Circulating microparticles (MPs) from metabolic syndrome patients and those generated from apoptotic T-cells induce endothelial dysfunction; however, the molecular and cellular mechanism(s) underlying in the effects ...