Browsing by Author "Manichaikul, Ani"
Now showing items 1-4 of 4
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Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale
Li, Xihao; Li, Zilin; Zhou, Hufeng; Gaynor, Sheila M.; Liu, Yaowu; Chen, Han; Sun, Ryan; Dey, Rounak; Arnett, Donna K.; Aslibekyan, Stella; Ballantyne, Christie M.; Bielak, Lawrence F.; Blangero, John; Boerwinkle, Eric; Bowden, Donald W.; Broome, Jai G.; Conomos, Matthew P.; Correa, Adolfo; Cupples, L. Adrienne; Curran, Joanne E.; Freedman, Barry I.; Guo, Xiuqing; Hindy, George; Irvin, Marguerite R.; Kardia, Sharon L.R.; Kathiresan, Sekar; Khan, Alyna T.; Kooperberg, Charles L.; Laurie, Cathy C.; Liu, X. Shirley; Mahaney, Michael C.; Manichaikul, Ani W.; Martin, Lisa W.; Mathias, Rasika A.; McGarvey, Stephen T.; Mitchell, Braxton D.; Montasser, May E.; Moore, Jill E.; Morrison, Alanna C.; O’Connell, Jeffrey R.; Palmer, Nicholette D.; Pampana, Akhil; Peralta, Juan M.; Peyser, Patricia A.; Psaty, Bruce M.; Redline, Susan; Rice, Kenneth M.; Rich, Stephen S.; Smith, Jennifer A.; Tiwari, Hemant K.; Tsai, Michael Y.; Vasan, Ramachandran S.; Wang, Fei Fei; Weeks, Daniel E.; Weng, Zhiping; Wilson, James G.; Yanek, Lisa R.; Abe, Namiko; Abecasis, Gonçalo R.; Aguet, Francois; Albert, Christine; Almasy, Laura; Alonso, Alvaro; Ament, Seth; Anderson, Peter; Anugu, Pramod; Applebaum-Bowden, Deborah; Ardlie, Kristin; Arking, Dan; Ashley-Koch, Allison; Assimes, Tim; Auer, Paul; Avramopoulos, Dimitrios; Barnard, John; Barnes, Kathleen; Barr, R. Graham; Barron-Casella, Emily; Barwick, Lucas; Beaty, Terri; Beck, Gerald; Becker, Diane; Becker, Lewis; Beer, Rebecca; Beitelshees, Amber; Benjamin, Emelia; Benos, Takis; Bezerra, Marcos; Bis, Joshua; Blackwell, Thomas; Bowler, Russell; Brody, Jennifer; Broeckel, Ulrich; Bunting, Karen... more authors ... less authors ( Nature Research , 2020 , Article)Large-scale whole-genome sequencing studies have enabled the analysis of rare variants (RVs) associated with complex phenotypes. Commonly used RV association tests have limited scope to leverage variant functions. We propose ... -
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
Kanoni, Stavroula; Graham, Sarah E.; Wang, Yuxuan; Surakka, Ida; Ramdas, Shweta; Zhu, Xiang; Clarke, Shoa L.; Bhatti, Konain Fatima; Vedantam, Sailaja; Winkler, Thomas W.; Locke, Adam E.; Marouli, Eirini; Zajac, Greg J.M.; Wu, Kuan Han H.; Ntalla, Ioanna; Hui, Qin; Klarin, Derek; Hilliard, Austin T.; Wang, Zeyuan; Xue, Chao; Thorleifsson, Gudmar; Helgadottir, Anna; Gudbjartsson, Daniel F.; Holm, Hilma; Olafsson, Isleifur; Hwang, Mi Yeong; Han, Sohee; Akiyama, Masato; Sakaue, Saori; Terao, Chikashi; Kanai, Masahiro; Zhou, Wei; Brumpton, Ben M.; Rasheed, Humaira; Havulinna, Aki S.; Veturi, Yogasudha; Pacheco, Jennifer Allen; Rosenthal, Elisabeth A.; Lingren, Todd; Feng, Qi Ping; Kullo, Iftikhar J.; Narita, Akira; Takayama, Jun; Martin, Hilary C.; Hunt, Karen A.; Trivedi, Bhavi; Haessler, Jeffrey; Giulianini, Franco; Bradford, Yuki; Miller, Jason E.; Campbell, Archie; Lin, Kuang; Millwood, Iona Y.; Rasheed, Asif; Hindy, George; Faul, Jessica D.; Zhao, Wei; Weir, David R.; Turman, Constance; Huang, Hongyan; Graff, Mariaelisa; Choudhury, Ananyo; Sengupta, Dhriti; Mahajan, Anubha; Brown, Michael R.; Zhang, Weihua; Yu, Ketian; Schmidt, Ellen M.; Pandit, Anita; Gustafsson, Stefan; Yin, Xianyong; Luan, Jian’an; Zhao, Jing Hua; Matsuda, Fumihiko; Jang, Hye Mi; Yoon, Kyungheon; Medina-Gomez, Carolina; Pitsillides, Achilleas; Hottenga, Jouke Jan; Wood, Andrew R.; Ji, Yingji; Gao, Zishan; Haworth, Simon; Yousri, Noha A.; Mitchell, Ruth E.; Chai, Jin Fang; Aadahl, Mette; Bjerregaard, Anne A.; Yao, Jie; Manichaikul, Ani; Hwu, Chii Min; Hung, Yi Jen; Warren, Helen R.; Ramirez, Julia; Bork-Jensen, Jette; Kårhus, Line L.; Goel, Anuj; Sabater-Lleal, Maria; Noordam, Raymond; Mauro, Pala... more authors ... less authors ( BioMed Central , 2022 , Article)Background: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding ... -
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
Ramdas, Shweta; Judd, Jonathan; Graham, Sarah E.; Kanoni, Stavroula; Wang, Yuxuan; Surakka, Ida; Wenz, Brandon; Clarke, Shoa L.; Chesi, Alessandra; Wells, Andrew; Bhatti, Konain Fatima; Vedantam, Sailaja; Winkler, Thomas W.; Locke, Adam E.; Marouli, Eirini; Zajac, Greg J.M.; Wu, Kuan Han H.; Ntalla, Ioanna; Hui, Qin; Klarin, Derek; Hilliard, Austin T.; Wang, Zeyuan; Xue, Chao; Thorleifsson, Gudmar; Helgadottir, Anna; Gudbjartsson, Daniel F.; Holm, Hilma; Olafsson, Isleifur; Hwang, Mi Yeong; Han, Sohee; Akiyama, Masato; Sakaue, Saori; Terao, Chikashi; Kanai, Masahiro; Zhou, Wei; Brumpton, Ben M.; Rasheed, Humaira; Havulinna, Aki S.; Veturi, Yogasudha; Pacheco, Jennifer Allen; Rosenthal, Elisabeth A.; Lingren, Todd; Feng, Qi Ping; Kullo, Iftikhar J.; Narita, Akira; Takayama, Jun; Martin, Hilary C.; Hunt, Karen A.; Trivedi, Bhavi; Haessler, Jeffrey; Giulianini, Franco; Bradford, Yuki; Miller, Jason E.; Campbell, Archie; Lin, Kuang; Millwood, Iona Y.; Rasheed, Asif; Hindy, George; Faul, Jessica D.; Zhao, Wei; Weir, David R.; Turman, Constance; Huang, Hongyan; Graff, Mariaelisa; Choudhury, Ananyo; Sengupta, Dhriti; Mahajan, Anubha; Brown, Michael R.; Zhang, Weihua; Yu, Ketian; Schmidt, Ellen M.; Pandit, Anita; Gustafsson, Stefan; Yin, Xianyong; Luan, Jian'an; Zhao, Jing Hua; Matsuda, Fumihiko; Jang, Hye Mi; Yoon, Kyungheon; Medina-Gomez, Carolina; Pitsillides, Achilleas; Hottenga, Jouke Jan; Wood, Andrew R.; Ji, Yingji; Gao, Zishan; Haworth, Simon; Mitchell, Ruth E.; Chai, Jin Fang; Aadahl, Mette; Bjerregaard, Anne A.; Yao, Jie; Manichaikul, Ani; Lee, Wen Jane; Hsiung, Chao Agnes; Warren, Helen R.; Ramirez, Julia; Bork-Jensen, Jette; Kårhus, Line L.; Goel, Anuj; Sabater-Lleal, Maria... more authors ... less authors ( Elsevier , 2022 , Article)A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ... -
The power of genetic diversity in genome-wide association studies of lipids
Graham, Sarah E.; Clarke, Shoa L.; Wu, Kuan Han H.; Kanoni, Stavroula; Zajac, Greg J.M.; Ramdas, Shweta; Surakka, Ida; Ntalla, Ioanna; Vedantam, Sailaja; Winkler, Thomas W.; Locke, Adam E.; Marouli, Eirini; Hwang, Mi Yeong; Han, Sohee; Narita, Akira; Choudhury, Ananyo; Bentley, Amy R.; Ekoru, Kenneth; Verma, Anurag; Trivedi, Bhavi; Martin, Hilary C.; Hunt, Karen A.; Hui, Qin; Klarin, Derek; Zhu, Xiang; Thorleifsson, Gudmar; Helgadottir, Anna; Gudbjartsson, Daniel F.; Holm, Hilma; Olafsson, Isleifur; Akiyama, Masato; Sakaue, Saori; Terao, Chikashi; Kanai, Masahiro; Zhou, Wei; Brumpton, Ben M.; Rasheed, Humaira; Ruotsalainen, Sanni E.; Havulinna, Aki S.; Veturi, Yogasudha; Feng, Qi Ping; Rosenthal, Elisabeth A.; Lingren, Todd; Pacheco, Jennifer Allen; Pendergrass, Sarah A.; Haessler, Jeffrey; Giulianini, Franco; Bradford, Yuki; Miller, Jason E.; Campbell, Archie; Lin, Kuang; Millwood, Iona Y.; Hindy, George; Rasheed, Asif; Faul, Jessica D.; Zhao, Wei; Weir, David R.; Turman, Constance; Huang, Hongyan; Graff, Mariaelisa; Mahajan, Anubha; Brown, Michael R.; Zhang, Weihua; Yu, Ketian; Schmidt, Ellen M.; Pandit, Anita; Gustafsson, Stefan; Yin, Xianyong; Luan, Jian’an; Zhao, Jing Hua; Matsuda, Fumihiko; Jang, Hye Mi; Yoon, Kyungheon; Medina-Gomez, Carolina; Pitsillides, Achilleas; Hottenga, Jouke Jan; Willemsen, Gonneke; Wood, Andrew R.; Ji, Yingji; Gao, Zishan; Haworth, Simon; Mitchell, Ruth E.; Chai, Jin Fang; Aadahl, Mette; Yao, Jie; Manichaikul, Ani; Warren, Helen R.; Ramirez, Julia; Bork-Jensen, Jette; Kårhus, Line L.; Goel, Anuj; Sabater-Lleal, Maria; Noordam, Raymond; Sidore, Carlo; Fiorillo, Edoardo; McDaid, Aaron F.; Marques-Vidal, Pedro; Wielscher, Matthias; Trompet, Stella; Sattar, Naveed... more authors ... less authors ( Nature Research , 2021 , Article)Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different dietary patterns and medication use1. Despite advances in prevention and treatment, in ...