Browsing by Author "Pintus, Gianfranco"
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Activation of the pro-oxidant PKC?IIp66Shc Signaling pathway contributes to pericyte dysfunction in skeletal muscles of patients with diabetes with critical limb Ischemia
Vono, Rosa; Fuoco, Claudia; Testa, Stefano; Pirro, Stefano; Maselli, David; Ferl, David; McCollough; Sangalli, Elena; Pintus, Gianfranco; Giordo, Roberta; Finzi, Giovanna; Sessa, Fausto; Cardani, Rosanna; Gotti, Ambra; Losa, Sergio; Cesareni, Gianni; Rizzi, Roberto; Bearzi, Claudia; Cannata, Stefano; Spinetti, Gaia; Gargioli, Cesare; Madeddu, Paolo... more authors ... less authors ( American Diabetes Association Inc. , 2016 , Article)Critical limb ischemia (CLI), foot ulcers, former amputation, and impaired regeneration are independent risk factors for limb amputation in subjects with diabetes. The present work investigates whether and by which mechanism ... -
Activation of the Pro-Oxidant PKCβII-p66Shc Signaling Pathway Contributes to Pericyte Dysfunction in Skeletal Muscles of Diabetic Patients with Critical Limb Ischemia
Vono, Rosa; Fuoco, Claudio; Testa, Stefano; Pirrò, Stefano; Maselli, Davide; McCollough, David Ferland; Sangalli, Elena; Pintus, Gianfranco; Giordo, Roberta; Finzi, Giovanna; Sessa, Fausto; Cardani, Rosanna; Gotti, Ambra; Losa, Sergio; Cesareni, Gianni; Rizzi, Roberto; Bearzi, Claudia; Cannata, Stefano; Spinetti, Gaia; Gargioli, Cesare; Madeddu, Paolo... more authors ... less authors ( American Diabetes Association , 2016 , Article)Critical limb ischemia (CLI), foot ulcers, former amputation and impaired regeneration are independent risk factors for limb amputation in diabetic subjects. The present work investigates whether and by which mechanism ... -
AEO-7 surfactant is “super toxic” and induces severe cardiac, liver and locomotion damage in zebrafish embryos
Al-Asmakh, Maha; Majdalawieh, Amin F.; Abdullah, Aboubakr M.; Younes, Nadin; Da’as, Sahar I.; Radwan, A. Bahgat; Sliem, Mostafa H.; Ech-Cherif, Houria; Pintus, Gianfranco; Nasrallah, Gheyath K.... more authors ... less authors ( SpringerOpen , 2020 , Article)© 2020, The Author(s). Background: Fatty alcohol polyoxyethylene ether-7 (AEO-7), a non-ionic surfactant, has recently been receiving extensive attention from the ocean pipeline industry for its ability to inhibit corrosion. ... -
An updated overview of cyanidins for chemoprevention and cancer therapy
Posadino, Anna Maria; Giordo, Roberta; Ramli, Iman; Zayed, Hatem; Nasrallah, Gheyath K.; Wehbe, Zena; Eid, Ali H.; Gürer, Eda Sönmez; Kennedy, John F.; Aldahish, Afaf Ahmed; Calina, Daniela; Razis, Ahmad Faizal Abdull; Modu, Babagana; Habtemariam, Solomon; Sharifi-Rad, Javad; Pintus, Gianfranco; Cho, William C.... more authors ... less authors ( Elsevier , 2023 , Article Review)Anthocyanins are colored polyphenolic compounds that belong to the flavonoids family and are largely present in many vegetables and fruits. They have been used in traditional medicine in many cultures for a long time. The ... -
Antioxidant Activity Mediates Pirfenidone Antifibrotic Effects in Human Pulmonary Vascular Smooth Muscle Cells Exposed to Sera of Idiopathic Pulmonary Fibrosis Patients.
Fois, Alessandro Giuseppe; Posadino, Anna Maria; Giordo, Roberta; Cossu, Annalisa; Agouni, Abdelali; Rizk, Nasser Moustafa; Pirina, Pietro; Carru, Ciriaco; Zinellu, Angelo; Pintus, Gianfranco... more authors ... less authors ( Hindawi Publishing Corporation , 2018 , Article)Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by an exacerbated fibrotic response. Although molecular and cellular determinants involved in the onset and progression of this devastating disease ... -
Cellular immune activation in Sardinian middle-aged, older adults and centenarians
Sotgia, Salvatore; Zinellu, Angelo; Mangoni, Arduino A; Serra, Roberta; Pintus, Gianfranco; Caruso, Calogero; Deiana, Luca; Carru, Ciriaco... more authors ... less authors ( Elsevier , 2017 , Article)In addition to viral infections, malignant disorders, autoimmune diseases, and allograft rejection episodes, neopterin increases in older people where it is found to be predictive of overall mortality. Thus, the serum ... -
Crosstalk Between Oxidative Stress and Endoplasmic Reticulum (ER) Stress in Endothelial Dysfunction and Aberrant Angiogenesis Associated With Diabetes: A Focus on the Protective Roles of Heme Oxygenase (HO)-1
Maamoun, Hatem; Benameur, Tarek; Pintus, Gianfranco; Munusamy, Shankar; Agouni, Abdelali ( Frontiers Media , 2019 , Article Review)Type-2 diabetes prevalence is continuing to rise worldwide due to physical inactivity and obesity epidemic. Diabetes and fluctuations of blood sugar are related to multiple micro- and macrovascular complications, that are ... -
Cytoprotective, antioxidant, and anti-migratory activity of Pistacia lentiscus L. supercritical carbon dioxide extract on primary human endothelial cells
Giordo, Roberta; Cossu, Annalisa; Porcu, Maria Cristina; Cappuccinelli, Roberto; Biosa, Grazia; Sharifi-Rad, Javad; Pretti, Luca; Nasrallah, Gheyath K.; Pintus, Gianfranco; Posadino, Anna Maria... more authors ... less authors ( Taylor & Francis , 2022 , Article)Green chemistry is a useful tool for producing valuable chemicals from biomass. However, extracted compounds need to be tested for safety and efficacy before their use in humans. Here we investigate the chemical composition ... -
D-Dimer Concentrations and COVID-19 Severity: A Systematic Review and Meta-Analysis
Paliogiannis, Panagiotis; Mangoni, Arduino; Dettori, Paola; Nasrallah, Gheyath; Pintus, Gianfranco; Zinellu, Angelo... more authors ... less authors ( Frontiers Media , 2020 , Article Review)Coronavirus disease 2019 (COVID-19) is a recently described infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since late 2019, COVID-19 has rapidly spread in virtually all countries, ... -
Ecotoxicological Assessment of Thermally- and Hydrogen-Reduced Graphene Oxide/TiO₂ Photocatalytic Nanocomposites Using the Zebrafish Embryo Model.
Al-Kandari, Halema; Younes, Nadin; Al-Jamal, Ola; Zakaria, Zain Z; Najjar, Huda; Alserr, Farah; Pintus, Gianfranco; Al-Asmakh, Maha A; Abdullah, Aboubakr M; Nasrallah, Gheyath K... more authors ... less authors ( MDPI , 2019 , Article)Advanced oxidation processes (AOPs) have recently attracted great interest in water pollution management. Using the zebrafish embryo model, we investigated the environmental impacts of two thermally (RGOTi)- and hydrogen ... -
Effect of Resveratrol on Pregnancy, Prenatal Complications and Pregnancy-Associated Structure Alterations.
Ramli, Iman; Posadino, Anna Maria; Giordo, Roberta; Fenu, Grazia; Fardoun, Manal; Iratni, Rabah; Eid, Ali H; Zayed, Hatem; Pintus, Gianfranco... more authors ... less authors ( MDPI , 2023 , Article Review)Adverse pregnancy outcomes are considered significant health risks for pregnant women and their offspring during pregnancy and throughout their lifespan. These outcomes lead to a perturbated in-utero environment that impacts ... -
Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis.
Phan, Thị Hằng Giang; Paliogiannis, Panagiotis; Nasrallah, Gheyath K; Giordo, Roberta; Eid, Ali Hussein; Fois, Alessandro Giuseppe; Zinellu, Angelo; Mangoni, Arduino Aleksander; Pintus, Gianfranco... more authors ... less authors ( Springer , 2020 , Article Review)Idiopathic pulmonary fibrosis (IPF), the most common form of idiopathic interstitial pneumonia, is a progressive, irreversible, and typically lethal disease characterized by an abnormal fibrotic response involving vast ... -
EndMT regulation by small RNAs in diabetes-associated fibrotic conditions: potential link with oxidative stress
Giordo, Roberta; Mohammed, Yusra; Allam, Hilda; Abusnana, Salah; Pappalardo, Lucia; Nasrallah, Gheyath; Mangoni, Arduino; Pintus, Gianfranco... more authors ... less authors ( Frontiers Media , 2021 , Article)Diabetes-associated complications, such as retinopathy, nephropathy, cardiomyopathy, and atherosclerosis, the main consequences of long-term hyperglycemia, often lead to organ dysfunction, disability, and increased mortality. ... -
Epac as a tractable therapeutic target
Hasan, Slika; Mansour, Hadi; Nasser, Suzanne A.; Shaito, Abdullah; Kobeissy, Firas; Orekhov, Alexander N.; Pintus, Gianfranco; Eid, Ali H.... more authors ... less authors ( Elsevier , 2023 , Article)In 1957, cyclic adenosine monophosphate (cAMP) was identified as the first secondary messenger, and the first signaling cascade discovered was the cAMP-protein kinase A (PKA) pathway. Since then, cAMP has received increasing ... -
Epstein–Barr Virus Epidemiology, Serology, and Genetic Variability of LMP-1 Oncogene Among Healthy Population: An Update
Smatti, Maria K.; Al-Sadeq, Duaa W.; Ali, Nadima H.; Pintus, Gianfranco; Abou-Saleh, Haissam; Nasrallah, Gheyath K.... more authors ... less authors ( Frontiers Medi , 2018 , Article Review)The Epstein–Barr virus (EBV) is a DNA lymphotropic herpesvirus and the causative agent of infectious mononucleosis. EBV is highly prevalent since it affects more than 90% of individuals worldwide and has been linked to ... -
Evaluation of Global Genomic DNA Methylation in Human Whole Blood by Capillary Electrophoresis UV Detection
Zinellu, Angelo; Sotgiu, Elisabetta; Assaretti, Stefano; Sotgia, Salvatore; Paliogiannis, Panagiotis; Pintus, Gianfranco; Mangoni, Arduino A.; Carru, Ciriaco... more authors ... less authors ( Hindawi Publishing Corporation , 2017 , Article)Alterations in global DNA methylation are implicated in various pathophysiological processes. The development of simple and quick, yet robust, methods to assess DNA methylation is required to facilitate its measurement and ... -
Flavin Oxidase-Induced ROS Generation Modulates PKC Biphasic Effect of Resveratrol on Endothelial Cell Survival.
Posadino, Anna Maria; Giordo, Roberta; Cossu, Annalisa; Nasrallah, Gheyath K; Shaito, Abdullah; Abou-Saleh, Haissam; Eid, Ali H; Pintus, Gianfranco... more authors ... less authors ( MDPI , 2019 , Article)Dietary intake of natural antioxidants is thought to impart protection against oxidative-associated cardiovascular diseases. Despite many in vivo studies and clinical trials, this issue has not been conclusively resolved. ... -
Flavonoids in hypertension: a brief review of the underlying mechanisms.
Maaliki, Dina; Shaito, Abdullah A; Pintus, Gianfranco; El-Yazbi, Ahmed; Eid, Ali H ( Elsevier , 2019 , Article)Flavonoids are a diverse group of bioactive polyphenolic compounds abundant in dietary plants and herbs. Regular consumption of flavonoids exerts cardio-vasculoprotective effects and may reduce the onset or progression of ... -
Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety
Shaito, Abdullah; Thuan, Duong Thi Bich; Phu, Hoa Thi; Nguyen, Thi Hieu Dung; Hasan, Hiba; Halabi, Sarah; Abdelhady, Samar; Nasrallah, Gheyath K.; Eid, Ali H.; Pintus, Gianfranco... more authors ... less authors ( Frontiers Media S.A. , 2020 , Article)Cardiovascular diseases (CVDs) are a significant health burden with an ever-increasing prevalence. They remain the leading causes of morbidity and mortality worldwide. The use of medicinal herbs continues to be an ... -
Herbal medicine for slowing aging and aging-associated conditions: Efficacy, mechanisms and safety
Phu, Hoa T.; Thuan, Duong T.B.; Nguyen, Thi H.D.; Posadino, Anna M.; Eid, Ali H.; Pintus, Gianfranco... more authors ... less authors ( Bentham , 2020 , Article)Aging and aging-associated diseases are issues with unsatisfactory answers in the medical field. Aging causes important physical changes which, even in the absence of the usual risk factors, render the cardiovascular system ...