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    D-Dimer Concentrations and COVID-19 Severity: A Systematic Review and Meta-Analysis

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    fpubh-08-00432.pdf (2.213Mb)
    Date
    2020-08-04
    Author
    Paliogiannis, Panagiotis
    Mangoni, Arduino
    Dettori, Paola
    Nasrallah, Gheyath
    Pintus, Gianfranco
    Zinellu, Angelo
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    Abstract
    Coronavirus disease 2019 (COVID-19) is a recently described infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since late 2019, COVID-19 has rapidly spread in virtually all countries, imposing the adoption of significant lockdown and social distancing measures. The activation of the coagulation cascade is a common feature of disseminated intravascular coagulation and adverse clinical outcomes in COVID-19 patients. In this study, we conducted a meta-analysis aiming to investigate differences in serum D-dimer concentrations in patients with and without severe COVID-19 disease. An electronic search in Medline (PubMed), Scopus and Web of Science was performed with no language restrictions, and 13 articles were reporting on 1,807 patients (585, 32.4% with severe disease) were finally identified and included in the meta-analysis. The pooled results of all studies revealed that the D-dimer concentrations were significantly higher in patients with more severe COVID-19 (SMD: 0.91 mg/L; 95% CI, 0.75 to 1.07 mg/L, p < 0.0001). The heterogeneity was moderate (I 2 = 46.5%; p = 0.033). Sensitivity analysis showed that the effect size was not modified when any single study was in turn removed (effect size range, 0.87 mg/L to 0.93 mg/L). The Begg’s (p = 0.76) and Egger’s tests (p = 0.38) showed no publication bias. In conclusion, our systematic review and meta-analysis showed that serum D-dimer concentrations in patients with severe COVID-19 are significantly higher when compared to those with non-severe forms.
    DOI/handle
    http://dx.doi.org/10.3389/fpubh.2020.00432
    http://hdl.handle.net/10576/15426
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    • Biomedical Sciences [‎834‎ items ]
    • COVID-19 Research [‎849‎ items ]

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