Browsing by Author "El-Yazbi, Ahmed"
Now showing items 1-15 of 15
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Adipose tissue immunomodulation: A novel therapeutic approach in cardiovascular and metabolic diseases
Alzaim, Ibrahim; Hammoud, Safaa H.; Al-Koussa, Houssam; Ghazi, Alaa; Eid, Ali H.; El-Yazbi, Ahmed F.... more authors ... less authors ( Frontiers Media , 2020 , Article)Adipose tissue is a critical regulator of systemic metabolism and bodily homeostasis as it secretes a myriad of adipokines, including inflammatory and anti-inflammatory cytokines. As the main storage pool of lipids, ... -
Adipose tissue mitochondrial dysfunction and cardiometabolic diseases: On the search for novel molecular targets
Ibrahim, AlZaim; Eid, Ali H.; Abd-Elrahman, Khaled S.; El-Yazbi, Ahmed F. ( Elsevier , 2022 , Article)Cardiometabolic diseases present an escalating global health and economic burden. Such a surge is driven by epidemic prevalence rates of metabolic disorders, such as obesity and type 2 diabetes, and their associated ... -
Corrigendum to “Peri-renal adipose inflammation contributes to renal dysfunction in a non-obese prediabetic rat model: Role of anti-diabetic drugs” [Biochem. Pharmacol. 186 (2021) 114491]
Hammoud, Safaa H.; AlZaim, Ibrahim; Mougharbil, Nahed; Koubar, Sahar; Eid, Ali H.; Eid, Assaad A.; El-Yazbi, Ahmed F.... more authors ... less authors ( Elsevier , 2023 , Other)We regret to report that a mistake occurred in preparation of Fig. 4. The modified figure is included below. We apologize for any confusion this might have created. -
Early metabolic impairment as a contributor to neurodegenerative disease: Mechanisms and potential pharmacological intervention
Fakih, Walaa; Zeitoun, Ralph; AlZaim, Ibrahim; Eid, Ali H.; Kobeissy, Firas; Abd-Elrahman, Khaled S.; El-Yazbi, Ahmed F.... more authors ... less authors ( Wiley , 2022 , Article Review)The metabolic syndrome comprises a family of clinical and laboratory findings, including insulin resistance, hyperglycemia, hypertriglyceridemia, low high-density lipoprotein cholesterol levels, and hypertension, in addition ... -
Editorial: Methods and application in cardiovascular and smooth muscle pharmacology: 2021
El-Yazbi, Ahmed F.; Eid, Ali H.; Zouein, Fouad A.; Abd-Elrahman, Khaled S. ( Frontiers Media S.A. , 2022 , Other)Despite significant advances in basic, translational, and clinical research tackling heart disease, cardiovascular pathologies remain among the leading causes of mortality and morbidity worldwide, being responsible for ... -
High fat diet exacerbates long-term metabolic, neuropathological, and behavioral derangements in an experimental mouse model of traumatic brain injury
Stanley, Ibeh; Bakkar, Nour-Mounira Z.; Ahmad, Fatima; Nwaiwu, Judith; Barsa, Chloe; Mekhjian, Sarine; Reslan, Mohammad Amine; Eid, Ali H.; Harati, Hayat; Nabha, Sanaa; Mechref, Yehia; El-Yazbi, Ahmed F.; Kobeissy, Firas... more authors ... less authors ( Elsevier , 2023 , Article)AimsTraumatic brain injury (TBI) constitutes a serious public health concern. Although TBI targets the brain, it can exert several systemic effects which can worsen the complications observed in TBI subjects. Currently, ... -
Mechanisms underlying the effects of caloric restriction on hypertension
Ahmad A., Al Attar; Fahed, Gracia I.; Hoballah, Malak M.; Pedersen, Shona; El-Yazbi, Ahmed F.; Nasser, Suzanne A.; Bitto, Alessandra; Orekhov, Alexander N.; Eid, Ali H.... more authors ... less authors ( Elsevier , 2022 , Article)Hypertension is a major risk factor for cardiovascular disease (CVD) as well as a major contributor to all-cause mortality and disability worldwide. The pathophysiology of hypertension is highly attributed to a dysfunctional ... -
Peri-renal adipose inflammation contributes to renal dysfunction in a non-obese prediabetic rat model: Role of anti-diabetic drugs
Hammoud, Safaa H.; AlZaim, Ibrahim; Mougharbil, Nahed; Koubar, Sahar; Eid, Ali H.; Eid, Assaad A.; El-Yazbi, Ahmed F.... more authors ... less authors ( Elsevier , 2021 , Article)Diabetic nephropathy is a major health challenge with considerable economic burden and significant impact on patients’ quality of life. Despite recent advances in diabetic patient care, current clinical practice guidelines ... -
Perirenal Adipose Tissue Inflammation: Novel Insights Linking Metabolic Dysfunction to Renal Diseases
Hammoud, Safaa H.; AlZaim, Ibrahim; Al-Dhaheri, Yusra; Eid, Ali H.; El-Yazbi, Ahmed F. ( Frontiers Media S.A. , 2021 , Article)A healthy adipose tissue (AT) is indispensable to human wellbeing. Among other roles, it contributes to energy homeostasis and provides insulation for internal organs. Adipocytes were previously thought to be a passive ... -
Role of RhoA and Rho-associated kinase in phenotypic switching of vascular smooth muscle cells: Implications for vascular function
Tedy, Sawma; Shaito, Abdullah; Najm, Nicolas; Sidani, Munir; Orekhov, Alexander; El-Yazbi, Ahmed F.; Iratni, Rabah; Eid, Ali H.... more authors ... less authors ( Elsevier , 2022 , Article Review)Cardiovascular disease (CVD) continues to be the primary cause of global mortality. Vascular smooth muscle cells (VSMCs) are integral components of vascular structure and function, evident by their vital roles in modulating ... -
Sex Differences in Cardiovascular Impact of Early Metabolic Impairment: Interplay between Dysbiosis and Adipose Inflammation
Dwaib, Haneen S.; AlZaim, Ibrahim; Ajouz, Ghina; Eid, Ali H.; El-Yazbi, Ahmed ( American Society for Pharmacology and Experimental Therapy (ASPET) , 2022 , Article)The evolving view of gut microbiota has shifted toward describing the colonic flora as a dynamic organ in continuous interaction with systemic physiologic processes. Alterations of the normal gut bacterial profile, known ... -
The pleiotropic effects of antithrombotic drugs in the metabolic-cardiovascular-neurodegenerative disease continuum: Impact beyond reduced clotting
Alaaeddine, Rana A.; AlZaim, Ibrahim; Hammoud, Safaa H.; Arakji, Aya; Eid, Ali H.; Abd-Elrahman, Khaled S.; El-Yazbi, Ahmed F.... more authors ... less authors ( Portland Press Ltd , 2021 , Article Review)Antithrombotic drugs are widely used for primary and secondary prevention, as well as treatment of many cardiovascular disorders. Over the past few decades, major advances in the pharmacology of these agents have been made ... -
Thromboinflammatory Processes at the Nexus of Metabolic Dysfunction and Prostate Cancer: The Emerging Role of Periprostatic Adipose Tissue
Alzaim, Ibrahim; Al-Saidi, Aya; Hammoud, Safaa H.; Darwiche, Nadine; Al-Dhaheri, Yusra; Eid, Ali H.; El-Yazbi, Ahmed F.... more authors ... less authors ( MDPI , 2022 , Article)The increased global prevalence of metabolic disorders including obesity, insulin resistance, metabolic syndrome and diabetes is mirrored by an increased incidence of prostate cancer (PCa). Ample evidence suggests that ... -
Western diet aggravates neuronal insult in post-traumatic brain injury: Proposed pathways for interplay
Abdullah, Shaito; Hasan, Hiba; Habashy, Karl John; Fakih, Walaa; Abdelhady, Samar; Ahmad, Fatima; Zibara, Kazem; Eid, Ali H.; El-Yazbi, Ahmed F.; Kobeissy, Firas H.... more authors ... less authors ( Elsevier , 2020 , Article Review)Traumatic brain injury (TBI) is a global health burden and a major cause of disability and mortality. An early cascade of physical and structural damaging events starts immediately post-TBI. This primary injury event ... -
Worsening baroreflex sensitivity on progression to type 2 diabetes: Localized vs. systemic inflammation and role of antidiabetic therapy
Bakkar, Nour-Mounira Z.; Mougharbil, Nahed; Mroueh, Ali; Kaplan, Abdullah; Eid, Ali H.; Fares, Souha; Zouein, Fouad A.; El-Yazbi, Ahmed F.... more authors ... less authors ( American Physiological Society , 2020 , Article)Cardiac autonomic neuropathy (CAN) is an early cardiovascular manifestation of type 2 diabetes (T2D) that constitutes an independent risk factor for cardiovascular mortality and morbidity. Nevertheless, its underlying ...