Browsing by Author "Kathiresan, Sekar"

Now showing items 1-6 of 6

    • Association of Habitual Alcohol Intake with Risk of Cardiovascular Disease 

      Biddinger, Kiran J.; Emdin, Connor A.; Haas, Mary E.; Wang, Minxian; Hindy, George; ... more authors ( American Medical Association , 2022 , Article)
      Importance: Observational studies have consistently proposed cardiovascular benefits associated with light alcohol consumption, while recent genetic analyses (ie, mendelian randomization studies) have suggested a possible ...

    • Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants 

      Aragam, Krishna G.; Jiang, Tao; Goel, Anuj; Kanoni, Stavroula; Wolford, Brooke N.; ... more authors ( Nature Research , 2022 , Article)
      The discovery of genetic loci associated with complex diseases has outpaced the elucidation of mechanisms of disease pathogenesis. Here we conducted a genome-wide association study (GWAS) for coronary artery disease (CAD) ...

    • Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale 

      Li, Xihao; Li, Zilin; Zhou, Hufeng; Gaynor, Sheila M.; Liu, Yaowu; ... more authors ( Nature Research , 2020 , Article)
      Large-scale whole-genome sequencing studies have enabled the analysis of rare variants (RVs) associated with complex phenotypes. Commonly used RV association tests have limited scope to leverage variant functions. We propose ...

    • Genome-wide polygenic score, clinical risk factors, and long-term trajectories of coronary artery disease 

      Hindy, George; Aragam, Krishna G.; Ng, Kenney; Chaffin, Mark; Lotta, Luca A.; ... more authors ( American Heart Association , 2020 , Article)
      OBJECTIVE: To determine the relationship of a genome-wide polygenic score for coronary artery disease (GPSCAD) with lifetime trajectories of CAD risk, directly compare its predictive capacity to traditional risk factors, ...

    • Rare coding variants in 35 genes associate with circulating lipid levels—A multi-ancestry analysis of 170,000 exomes 

      George, Hindy; Dornbos, Peter; Chaffin, Mark D.; Liu, Dajiang J.; Wang, Minxian; ... more authors ( Elsevier , 2022 , Article)
      Large-scale gene sequencing studies for complex traits have the potential to identify causal genes with therapeutic implications. We performed gene-based association testing of blood lipid levels with rare (minor allele ...

    • Transethnic Transferability of a Genome-wide Polygenic Score for Coronary Artery Disease. 

      Fahed, Akl C; Aragam, Krishna G; Hindy, George; Chen, Yii-Der Ida; Chaudhary, Kumardeep; ... more authors ( American Heart Association , 2020 , Article)
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