Browsing by Author "Sahebkar, Amirhossein"

Now showing items 1-20 of 85

    • Adrenoceptor Desensitization: Current Understanding of Mechanisms 

      Maaliki, Dina; Jaffa, Aneese A.; Nasser, Suzanne; Sahebkar, Amirhossein; Eid, Ali H. ( The American Society for Pharmacology and Experimental Therapeutics , 2024 , Article Review)
      G-protein coupled receptors (GPCRs) transduce a wide range of extracellular signals. They are key players in the majority of biologic functions including vision, olfaction, chemotaxis, and immunity. However, as essential ...

    • Advancements in decoy oligodeoxynucleotides targeting STAT3 and STAT5 for cancer therapy 

      Maryam, Mahjoubin-Tehran; Rezaei, Samaneh; Eid, Ali H.; Kesharwani, Prashant; Sahebkar, Amirhossein ( Elsevier , 2025 , Article)
      The Signal Transducer and Activator of Transcription (STAT) proteins are a group of cytoplasmic transcription factors. This group comprises seven members, named STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, and STAT6. These ...

    • Bariatric Surgery Improves Serum CD40L Levels as a Predictor of Cardiovascular Risk: Systematic Review and Meta-analysis 

      Jamialahamdi, Tannaz; Eid, Ali H.; Nguyen, Ninh T.; Gadde, Kishore M.; Sukhorukov, Vasily N.; ... more authors (2024 , Article)
      CD40 and its ligand have been recently implicated in the pathogenesis of cardiovascular disease (CVD). This meta-analysis examined the effect of bariatric surgery in reducing circulating CD40L levels. A systematic review ...

    • Beyond fat: Does semaglutide affect lean mass? 

      Tannaz, Jamialahmadi; Eid, Ali H.; Gadde, Kishore M.; Almahmeed, Wael; Kroh, Matthew; ... more authors ( Elsevier , 2025 , Article)
      This opinion paper aims to discuss the influence of semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), on lean mass beyond its impact on weight loss. Although significant weight loss is achieved with ...

    • Biochemical and cellular basis of oxidative stress: Implications for disease onset 

      Aramouni, Karl; Assaf, Roland; Shaito, Abdullah; Fardoun, Manal; Al-Asmakh, Maha; ... more authors ( Wiley , 2023 , Article Review)
      Cellular oxidation–reduction (redox) systems, which encompass pro- and antioxidant molecules, are integral components of a plethora of essential cellular processes. Any dysregulation of these systems can cause molecular ...

    • Bridging conventional medicine and traditional, complementary, and alternative approaches: Fostering collaborative attempts for a holistic healthcare system 

      Eid, Ali H.; Sahebkar, Amirhossein ( Elsevier , 2023 , Article)
      Dear Editor, We read the paper entitled “The future of integrative health: vision, values, and principles for positive, sustainable systemic change” by Kemper, which was published last month.1 The points discussed therein ...

    • Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the Global Burden of Disease Study 2021 

      Stein Emil, Vollset; Ababneh, Hazim S; Abate, Yohannes Habtegiorgis; Abbafati, Cristiana; Abbasgholizadeh, Rouzbeh; ... more authors ( Elsevier , 2024 , Article)
      BackgroundFuture trends in disease burden and drivers of health are of great interest to policy makers and the public at large. This information can be used for policy and long-term health investment, planning, and ...

    • C-peptide in diabetes: A player in a dual hormone disorder? 

      Dakroub, Ali; Dbouk, Ali; Asfour, Aref; Nasser, Suzanne A.; El-Yazbi, Ahmed F.; ... more authors ( Wiley-Blackwell , 2024 , Article)
      C-peptide, a byproduct of insulin synthesis believed to be biologically inert, is emerging as a multifunctional molecule. C-peptide serves an anti-inflammatory and anti-atherogenic role in type 1 diabetes mellitus (T1DM) ...

    • Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019. 

      Harvey, James D; Henrikson, Hannah Jacqueline; Lu, Dan; Pennini, Alyssa; Xu, Rixing; ... more authors ( American Medical Association , 2021 , Article)
      The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden. ...

    • Cardioprotective Effect of Rheum turkestanicum Against Doxorubicin-Induced Toxicity in Rats 

      Hosseini, Azar; Safari, Mohammad Kazem; Rajabian, Arezoo; Boroumand-Noughabi, Samaneh; Eid, Ali H.; ... more authors ( Frontiers Media S.A. , 2022 , Article)
      Background: Doxorubicin as an anti-cancer drug causes cardiotoxicity, limiting its tolerability and use. The mechanism of toxicity is due to free radical production and cardiomyocytes injury. This research evaluated Rheum ...

    • Cardioprotective effect of Sanguisorba minor against isoprenaline-induced myocardial infarction in rats 

      Hosseini, Azar; Ghorbani, Atieh; Alavi, Mohaddeseh Sadat; Forouhi, Nima; Rajabian, Arezoo; ... more authors ( Frontiers Media SA , 2023 , Article)
      Introduction: Oxidative stress is a major instigator of various cardiovascular diseases, including myocardial infarction (MI). Despite available drugs, there is still an increased need to look for alternative therapies or ...

    • Cholinergic Conundrum: A Pharmacological Perspective on the Acetylcholine Enigma of Depression 

      Khachab, Maha; Sahebkar, Amirhossein; Eid, Ali H. ( Bentham Science Publishers , 2025 , Article)
      The cholinergic hypothesis of depression has emerged as a compelling framework for understanding and treating this widespread mental health disorder. In this issue of Current Reviews in Clinical and Experimental Pharmacology, ...

    • Correction to: The Effect of Bariatric Surgery on PAI-1 Levels: A Systematic Review and Meta-analysis (Obesity Surgery, (2024), 34, 10, (3876-3887), 10.1007/s11695-024-07473-1) 

      Jamialahamdi, Tannaz; Mirhadi, Elaheh; Almahmeed, Wael; Sukhorukov, Vasily N.; Eid, Ali H.; ... more authors (2025 , Article)
      In the published article, in the Funding Section the grant number is incorrect. The correct grant number is 24-45-20004.

    • Development of a flexible liver phantom for hepatocellular carcinoma treatment planning: a useful tool for training & education 

      Al-Thani, Abdulla; Sharif, Abdulrahman; El Borgi, Sami; Abdulla, Shameel; Ahmed Saleh, Mahmoud Raja; ... more authors ( BioMed Central Ltd , 2024 , Article)
      Purpose: Hepatocellular carcinoma (HCC) is one of the most common types of liver cancer that could potentially be surrounded by healthy arteries or veins that a surgeon would have to avoid during treatment. A realistic 3D ...

    • Diagnostic Value of Non-invasive Liver Function Tests in Liver Fibrosis and Changes in These Parameters Post-metabolic Surgery 

      Jangjoo, Sara; Emami, Nima; Sahranavard, Mehrdad; Shah, Najeeb Z.; Alidadi, Mona; ... more authors ( Springer , 2023 , Article)
      Purpose: This study aimed to ascertain the diagnostic accuracy of non-invasive liver function tests in liver fibrosis and assess their changes after metabolic surgery. Materials and Methods: 1005 individuals with severe ...

    • The differential expression of adipose tissue genes in short, medium and long-term periods after bariatric surgery 

      Mahjoubin-Tehran, Maryam; Atkin, Stephen L.; Jamialahmadi, Tannaz; Kroh, Matthew; Eid, Ali H.; ... more authors ( Springer Nature , 2024 , Article)
      Bariatric surgery is an approved treatment for obesity that consistently improves metabolic syndrome, with well-documented beneficial effects on dyslipidemia, cardiovascular risk, nonalcoholic fatty liver disease and glucose ...

    • Drug-use disorders in the Eastern Mediterranean Region: a glance at GBD 2019 findings 

      Amirkafi, Ali; Mohammadi, Faezeh; Tehrani-Banihashemi, Arash; Abbasi-Kangevari, Mohsen; Abbasi-Kangevari, Zeinab; ... more authors ( Springer , 2023 , Article)
      Purpose: The aim of this study is to investigate drug use disorders which are a major cause of Disability Adjusted Life Years (DALYs) in the Eastern Mediterranean Region (EMR). Methods: This article is a part of the global ...

    • Drugs from the ocean floor 

      Maha, Khachab; Sahebkar, Amirhossein; Eid, Ali H. ( Elsevier , 2025 , Other)
      The past decades have demonstrated the pharmaceutical, nutraceutical, and market potentials of bioactive compounds extracted from marine organisms. These marine bioactive compounds possess unique chemical structures and ...

    • Effect of Bariatric Surgery on Intima Media Thickness: A Systematic Review and Meta-Analysis 

      Jamialahmadi, Tannaz; Reiner, Željko; Alidadi, Mona; Almahmeed, Wael; Kesharwani, Prashant; ... more authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)
      Background: Obesity, and in particular extreme obesity, as a global health problem is an important risk factor for many diseases, including atherosclerotic cardiovascular disease (ACVD). Bariatric surgery might stop or ...

    • The Effect of Bariatric Surgery on PAI-1 Levels: A Systematic Review and Meta-analysis 

      Jamialahamdi, Tannaz; Mirhadi, Elaheh; Almahmeed, Wael; Sukhorukov, Vasily N.; Eid, Ali H.; ... more authors ( Springer Nature , 2024 , Article)
      The purpose of this meta-analysis was to determine the effect of bariatric surgery on circulating PAI-1. The meta-analysis was provided by comprehensive meta-analysis (CMA) V4 software. Meta-analysis of 33 studies showed ...