Browsing by Author "Billa, Nashiru"
Now showing items 1-19 of 19
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Advances in delivery methods of Arthrospira platensis (spirulina) for enhanced therapeutic outcomes
( Taylor & Francis , 2022 , Article)Arthrospira platensis (A. platensis) aqueous extract has massive amounts of natural products that can be used as future drugs, such as C-phycocyanin, allophycocyanin, etc. This extract was chosen because of its high ... -
Applications of polydopaminic nanomaterials in mucosal drug delivery
( Elsevier , 2023 , Article Review)Polydopamine (PDA) is a biopolymer with unique physicochemical properties, including free-radical scavenging, high photothermal conversion efficiency, biocompatibility, biodegradability, excellent fluorescent and theranostic ... -
Characterization and ex vivo evaluation of curcumin nanoethosomes for melanoma treatment
( Taylor & Francis , 2022 , Article)This study aimed at developing curcumin nanoethosomes (Cur-Ets) with superior skin permeation intended for melanoma treatment. Although curcumin is active against many types of skin cancers, a suitable topical formulation ... -
Curcumin and Derivatives in Nanoformulations with Therapeutic Potential on Colorectal Cancer
( Springer Science and Business Media Deutschland GmbH , 2022 , Article)There is growing concern in the rise of colorectal cancer (CRC) cases globally, and with this rise is the presentation of drug resistance. Like other cancers, current treatment options are either invasive or manifest severe ... -
An evaluation of tocotrienol ethosomes for transdermal delivery using Strat-M® membrane and excised human skin
( Taylor and Francis Ltd. , 2021 , Article)Tocotrienol (TRF) ethosomes were developed and evaluated in vitro for potential transdermal delivery against melanoma. The optimised TRF ethosomal size ranged between 64.9 ± 2.2 nm to 79.6 ± 3.9 nm and zeta potential (ZP) ... -
Improved bioavailability of poorly soluble drugs through gastrointestinal muco-adhesion of lipid nanoparticles
( Multidisciplinary Digital Publishing Institute (MDPI) , 2021 , Article)Gastrointestinal absorption remains indispensable in the systemic delivery of most drugs, even though it presents several challenges that, paradoxically, may also provide opportunities that can be exploited to achieve ... -
Lyophilized drug-loaded solid lipid nanoparticles formulated with beeswax and theobroma oil
( MDPI AG , 2021 , Article)Solid lipid nanoparticles (SLNs) have the potential to enhance the systemic availability of an active pharmaceutical ingredient (API) or reduce its toxicity through uptake of the SLNs from the gastrointestinal tract or ... -
Nano-vitamin C: A promising candidate for therapeutic applications
( Elsevier , 2023 , Article Review)Vitamin C is an important nutrient implicated in different physiological functions in humans. Despite its important biological functions, therapeutic applications of vitamin C are rare and its use is further impacted by ... -
A novel approach of encapsulating curcumin and succinylated derivative in mannosylated-chitosan nanoparticles
( Elsevier , 2022 , Article)Curcumin (CUR) manifests anti-colon cancer activity but suffers from low solubility, bioavailability, and instability, rendering it not as effective as its chemotherapeutic cousins. Here, we conjugate CUR to succinic ... -
Orally Administered Amphotericin B Nanoformulations: Physical Properties of Nanoparticle Carriers on Bioavailability and Clinical Relevance
( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)Amphotericin B is an effective polyene antifungal considered as a “gold standard” in the management of fungal infections. Currently, it is administered mainly by IV due to poor aqueous solubility, which precludes its ... -
Pharmacokinetics and tissue distribution of an orally administered mucoadhesive chitosan-coated amphotericin B-Loaded nanostructured lipid carrier (NLC) in rats
( Taylor and Francis Inc. , 2020 , Article)Oral delivery of amphotericin B (AmpB) is desirable because it provides a more patient-friendly mode of administration compared to the current delivery approach akin with the marketed AmpB formulations. The goal of the ... -
Physicochemical modifications in microwave-irradiated chitosan: biopharmaceutical and medical applications
( Taylor & Francis , 2024 , Article)Biopharmaceutical and biomedical applications of chitosan has evolved exponentially in the past decade, owing to its unique physicochemical properties. However, further applications can be garnered from modified chitosan, ... -
The potential role of vitamin C in empowering cancer immunotherapy
( Elsevier , 2022 , Article)Vitamin C also known as L-ascorbic acid is a nutrient naturally occurring in many fruits and vegetables and widely known for its potent antioxidant activity. Several studies have highlighted the importance of using high ... -
Prospects of Curcumin Nanoformulations in Cancer Management
( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)There is increasing interest in the use of natural compounds with beneficial pharmacological effects for managing diseases. Curcumin (CUR) is a phytochemical that is reportedly effective against some cancers through its ... -
Soliciting the Oral Route as a Logical Approach to Managing Colon Cancer
( Frontiers Media S.A. , 2021 , Article)According to Global Cancer Incidence, Mortality and Prevalence (GLOBOCAN) 2018, colon cancer (CC) is the third most common cancer in men and second in women worldwide (Bray et al., 2018). Approximately 1.8 million new colon ... -
Solid Dispersion Formulations by FDM 3D Printing—A Review
( MDPI , 2022 , Article)Additive manufacturing (AM) is revolutionizing the way medicines are designed, manufactured, and utilized. Perhaps, AM appears to be ideal for the fit-for-purpose manufacturing of medicines in contrast to the several ... -
Studies on anti-colon cancer potential of nanoformulations of curcumin and succinylated curcumin in mannosylated chitosan
( Elsevier , 2023 , Article)Colon cancer (CRC) is the second leading cause of death and the third most diagnosed cancer worldwide. Although curcumin (CUR) has demonstrated a potent anticancer activity, it is characterized by its poor solubility, low ... -
A Validated Reverse-Phase High Performance Liquid Chromatography (RP-HPLC) Method for the Quantification of Gamma-Tocotrienol in Tocotrienol Rich Fractions of Crude Palm Oil
( Bentham , 2021 , Article)Background: Palm oil and its constituents have wide applications in food, cosmet-ics and pharmaceutical industries. The tocotrienol-rich fractions of crude palm oil have drawn greater research interest in recent years due ... -
A Window for Enhanced Oral Delivery of Therapeutics via Lipid Nanoparticles
( Dove Medical Press , 2024 , Article)Oral administration of dosage forms is convenient and beneficial in several respects. Lipid nanoparticulate dosage forms have emerged as a useful carrier system in deploying low solubility drugs systemically, particularly ...
