Browsing by Author "MRAICHE, FATIMA"
Now showing items 1-20 of 26
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Algae-derived bioactive compounds with anti-lung cancer potential
( MDPI , 2020 , Article Review)Lung cancer is one of the major causes of death worldwide. Natural molecules with anti-lung cancer potential are of a great interest and considered as very promising alternative to substitute or enhance the efficiency of ... -
Anti-hypertrophic effect of Na+/H+ exchanger-1 inhibition is mediated by reduced cathepsin B
( Elsevier , 2020 , Article)Previous studies have established the role of Na+/H+ exchanger isoform-1 (NHE1) and cathepsin B (Cat B) in the development of cardiomyocyte hypertrophy (CH). Both NHE1 and Cat B are activated under acidic conditions ... -
Asterarcys quadricellulare (Chlorophyceae) protects H9c2 cardiomyoblasts from H2O2-induced oxidative stress
( Springer , 2022 , Article)Oxidative stress has recently been identified as an important mediator of cardiovascular diseases. The need to find efficient antioxidant molecules is essential in the disease’s prevention. Therefore, the present study ... -
Cathepsin B Induced Cardiomyocyte Hypertrophy Requires Activation of The Na+/H+ Exchanger Isoform-1
(2016 , Master Thesis)Multiple studies have demonstrated that proteases, specifically cathepsin B (Cat B) and matrix metalloproteinase-9 (MMP-9) contribute to the remodeling of the extracellular matrix (ECM), a hallmark of cardiac hypertrophy ... -
The Cellular Interplay Between Na+/H+ Exchanger Isoform I and Osteopontin in Cardiac Hypertrophy
(2014 , Master Thesis)The Na+/H+ exchanger-1 (NHE1) is a ubiquitously expressed housekeeping glycoprotein that functions to regulate intracellular pH. Enhanced expression/activity of NHE1 has been implicated in cardiac hypertrophy (CH). Recently, ... -
Cisplatin encapsulated nanoparticles from polymer blends for anti-cancer drug delivery
( Royal Society of Chemistry , 2022 , Article)Developing novel nanocarriers for anticancer drug delivery has become a ‘promising niche’. The toxicity of the carrier and its efficacy in treatment modalities have become cardinal points as they can impede the progress ... -
Correction to: Developing Leadership Skills in Pharmacy Education
( Springer Nature , 2023 , Article)The article “Developing Leadership Skills in Pharmacy Education” was originally published electronically on the publisher’s internet portal on 22 March 2022 with an error in the author group. The family name of the third ... -
The design and implementation of an undergraduate health professional degree elective course on scientific writing, peer assessment, and critical appraisal
( Elsevier , 2022 , Other)Background and purpose: Strong writing skills are critical to the pharmacy profession. This paper describes the design, delivery, and impact of a course intended to develop pharmacy students' scientific writing, peer ... -
Developing Leadership Skills in Pharmacy Education
( Springer , 2022 , Article)Leadership could refer to holding official leadership positions or advocating for patients and the profession. Different pharmacy organizations recommend the inclusion of leadership development in pharmacy education and ... -
Editorial: Recent advancements in neoadjuvant chemotherapy for specific breast cancer subtypes
( Frontiers Media S.A. , 2022 , Article)Most locally advanced breast cancer patients undergo pre-surgery treatment known as neoadjuvant chemotherapy (NAC). The purpose of NAC is to reduce the tumor’s size and improve surgical outcomes, cosmetic results, and ... -
THE EFFECT OF GENETIC AND NON-GENETIC FACTORS ON WARFARIN DOSE VARIABILITY IN QATARI POPULATION
(2018 , Master Thesis)Introduction: Genetic and non-genetic factors were shown to affect warfarin dosing; however, their effect may vary from one population to the other. No previous studies were conducted on the Qatari population to elucidate ... -
The Efficacy of Etoposide on H9c2 Cardiomyoblasts Against Doxorubicin Induced Cardiotoxicity
( OMICS International , 2015 , Article)Background: Doxorubicin (DOX), a widely used anticancer drug, has been associated with cardiotoxicity. Recently, DOX-induced cardiotoxicity has been attributed to topoisomerase II (TOPII)-β expression and activity. In our ... -
Empagliflozin inhibits angiotensin II-induced hypertrophy in H9c2 cardiomyoblasts through inhibition of NHE1 expression
( Springer , 2022 , Article)Diabetes mellitus (DM)-induced cardiac morbidities have been the leading cause of death among diabetic patients. Recently, sodium-glucose cotransporter-2 (SGLT-2) inhibitors including empagliflozin (EMPA), which have been ... -
Evaluating the effects of sodium glucose co-transporter -2 inhibitors from a renin–angiotensin–aldosterone system perspective in patients infected with COVID-19: contextualizing findings from the dapagliflozin in respiratory failure in patients with COVID-19 study
( Springer , 2022 , Article Review)Numerous studies demonstrate parallels between CVD, type 2 diabetes mellitus (T2DM) and COVID-19 pathology, which accentuate pre-existing complications in patients infected with COVID-19 and potentially exacerbate the infection ... -
Examining Pharmacy Alumni’s Perceptions of Job Satisfaction, Achievements, and Preparedness: A Mixed-Methods Study
( Elsevier , 2023 , Article)ObjectivesThere is a scarcity of research that holistically explores pharmacy alumni’s employment experience and their professional performance. Job satisfaction is linked to professionals' productivity and their educational ... -
Identifying the core concepts of pharmacology education: A global initiative
( Wiley-Blackwell , 2022 , Article)Background and Purpose: In recent decades, a focus on the most critical and fundamental concepts has proven highly advantageous to students and educators in many science disciplines. Pharmacology, unlike microbiology, ... -
Inhibition of p90 ribosomal S6 kinase attenuates cell migration and proliferation of the human lung adenocarcinoma through phospho-GSK-3β and osteopontin
( Springer-Verlag , 2016 , Article)p90 ribosomal S6 kinase (p90RSK) constitutes a family of serine/threonine kinases that have been shown to be involved in cell proliferation of various malignancies via direct or indirect effects on the cell-cycle machinery. ... -
Na+/H+ exchanger isoform 1 induced osteopontin expression in cardiomyocytes involves NFAT3/Gata4
( Springer-Verlag , 2015 , Article)Osteopontin (OPN), a multifunctional glycophosphoprotein, has been reported to contribute to the development and progression of cardiac remodeling and hypertrophy. Cardiac-specific OPN knockout mice were protected against ... -
Nanotechnology – a robust tool for fighting the challenges of drug resistance in non-small cell lung cancer
( Beilstein-Institut Zur Forderung der Chemischen Wissenschaften , 2023 , Article)Genomic and proteomic mutation analysis is the standard of care for selecting candidates for therapies with tyrosine kinase inhibitors against the human epidermal growth factor receptor (EGFR TKI therapies) and further ... -
p90 ribosomal S6 kinase: a potential therapeutic target in lung cancer
( BioMed Central , 2016 , Article)A global survey of cancer has shown that lung cancer is the most common cause of the new cancer cases and cancer deaths in men worldwide. The mortality from lung cancer is more than the combined mortality from breast, ...
