Browsing by Author "Shaito, Abdullah"
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3D hydrogel/ bioactive glass scaffolds in bone tissue engineering: Status and future opportunities
Abdullah, Aldhaher; Shahabipour, Fahimeh; Shaito, Abdullah; Al-Assaf, Saphwan; Elnour, Ahmed A.M.; Sallam, El Bashier; Teimourtash, Shahin; Elfadil, Abdelgadir A.... more authors ... less authors ( Elsevier , 2023 , Article Review)Repairing significant bone defects remains a critical challenge, raising the clinical demand to design novel bone biomaterials that incorporate osteogenic and angiogenic properties to support the regeneration of vascularized ... -
Acute exposure to cigarette smoking followed by myocardial infarction aggravates renal damage in an in vivo mouse model
Kobeissy, Firas; Shaito, Abdullah; Kaplan, Abdullah; Baki, Lama; Hayek, Hassan; Dagher-Hamalian, Carole; Nehme, Ali; Ghali, Rana; Abidi, Emna; Husari, Ahmad; Zeidan, Asad; Zouein, Fouad A.; Zibara, Kazem... more authors ... less authors ( Hindawi Limited , 2017 , Article)Cigarette smoking (S) is a risk factor for progressive chronic kidney disease, renal dysfunction, and renal failure. In this study, the effect of smoking on kidney function was investigated in a mouse model of myocardial ... -
Attitudes and beliefs regarding the use of herbs and supplementary medications with COVID-19: A systematic review
Abderrezzaq, Soltani; Jaam, Myriam; Nazar, Zachariah; Stewart, Derek; Shaito, Abdullah ( Elsevier , 2022 , Article)Background and aimThere is growing interest in using herbs and supplementary medications to treat and/or prevent COVID-19, evidenced by multiple reports exploring their effectiveness and safety. From a health psychology ... -
Biochemical and cellular basis of oxidative stress: Implications for disease onset
Aramouni, Karl; Assaf, Roland; Shaito, Abdullah; Fardoun, Manal; Al-Asmakh, Maha; Sahebkar, Amirhossein; Eid, Ali H.... more authors ... less authors ( Wiley , 2023 , Article Review)Cellular oxidation–reduction (redox) systems, which encompass pro- and antioxidant molecules, are integral components of a plethora of essential cellular processes. Any dysregulation of these systems can cause molecular ... -
Biological applications of imiquimod analogues: An update (Review)
Obeid, Joelle; Shaito, Abdullah; Hajj, Hiba El; Deleuze-Masquefa, Carine; Bonnet, Pierre Antoine; El-Sabban, Marwan; Saliba, Jessica... more authors ... less authors ( Spandidos Publications , 2023 , Article Review)The last decade witnessed intensive efforts in drug discovery and the emergence of thousands of molecules with potential for use as therapeutic targets. However, only a few hundred of these molecules reached the stage of ... -
The Brain And Exercise: In Sickness And In Health
Reslan, Mohammad Amine; Tabet, Maha; Yehya, Yara; Shaito, Abdullah; Kobeissy, Firas ( Frontiers Media , 2022 , Article)The brain, like any other organ in the body, is made up of various types of cells. Nerve cells called neurons are the major cells in the brain. Their main function is to transfer messages and orders to and from the organs ... -
Cancer Metastasis: Dynamic Hetero-cellular Communications Between Cancer Cells and Host Tissues
Saliba, Jessica; El-Sabban, Maya; Shaito, Abdullah; El-Harakeh, Mohammad; Obeid, Joelle; El Hajj, Hiba; El-Sabban, Marwan... more authors ... less authors ( Springer International Publishing , 2023 , Book chapter)Metastasis is the most devastating aspect of cancer. Originally, tumor cells arise from a single clone, and then they undergo additional mutations and acquire invasive and metastatic features. These acquired mutations are ... -
Crosstalk between Microglia and Neurons in Neurotrauma: An Overview of the Underlying Mechanisms.
Haidar, Muhammad Ali; Ibeh, Stanley; Shakkour, Zaynab; Reslan, Mohammad Amine; Nwaiwu, Judith; Moqidem, Yomna Adel; Sader, Georgio; Nickles, Rachel G; Babale, Ismail; Jaffa, Aneese A; Salama, Mohamed; Shaito, Abdullah; Kobeissy, Firas... more authors ... less authors ( Bentham Science Publishers , 2022 , Article Review)Microglia are the resident immune cells of the brain and play a crucial role in housekeeping and maintaining homeostasis of the brain microenvironment. Upon injury or disease, microglial cells become activated, at least ... -
Epac as a tractable therapeutic target
Hasan, Slika; Mansour, Hadi; Nasser, Suzanne A.; Shaito, Abdullah; Kobeissy, Firas; Orekhov, Alexander N.; Pintus, Gianfranco; Eid, Ali H.... more authors ... less authors ( Elsevier , 2023 , Article)In 1957, cyclic adenosine monophosphate (cAMP) was identified as the first secondary messenger, and the first signaling cascade discovered was the cAMP-protein kinase A (PKA) pathway. Since then, cAMP has received increasing ... -
Ethanolic extract of Origanum syriacum L. leaves exhibits potent anti-breast cancer potential and robust antioxidant properties
Mesmar, Joelle; Abdallah, Rola; Hamade, Kamar; Baydoun, Serine; Al-Thani, Najlaa; Shaito, Abdullah; Maresca, Marc; Badran, Adnan; Baydoun, Elias... more authors ... less authors ( Frontiers Media , 2022 , Article)Background: Breast cancer (BC) is the second most common cancer overall. In women, BC is the most prevalent cancer and the leading cause of cancer-related mortality. Triple-negative BC (TNBC) is the most aggressive BC, ... -
Flavin Oxidase-Induced ROS Generation Modulates PKC Biphasic Effect of Resveratrol on Endothelial Cell Survival.
Posadino, Anna Maria; Giordo, Roberta; Cossu, Annalisa; Nasrallah, Gheyath K; Shaito, Abdullah; Abou-Saleh, Haissam; Eid, Ali H; Pintus, Gianfranco... more authors ... less authors ( MDPI , 2019 , Article)Dietary intake of natural antioxidants is thought to impart protection against oxidative-associated cardiovascular diseases. Despite many in vivo studies and clinical trials, this issue has not been conclusively resolved. ... -
Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety
Shaito, Abdullah; Thuan, Duong Thi Bich; Phu, Hoa Thi; Nguyen, Thi Hieu Dung; Hasan, Hiba; Halabi, Sarah; Abdelhady, Samar; Nasrallah, Gheyath K.; Eid, Ali H.; Pintus, Gianfranco... more authors ... less authors ( Frontiers Media S.A. , 2020 , Article)Cardiovascular diseases (CVDs) are a significant health burden with an ever-increasing prevalence. They remain the leading causes of morbidity and mortality worldwide. The use of medicinal herbs continues to be an ... -
Hormones in experimental autoimmune encephalomyelitis (EAE) animal models
Ghareghani, Majid; Ghanbari, Amir; Eid, Ali; Shaito, Abdullah; Mohamed, Wael; Mondello, Stefania; Zibara, Kazem... more authors ... less authors ( De Gruyter , 2021 , Article)Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) in which activated immune cells attack the CNS and cause inflammation and demyelination. While the etiology of MS is still ... -
Intercellular Communication in Cancer
Shaito, Abdullah; Saliba, Jessica; Obeid, Joelle; El-Harakeh, Mohammad; El Hajj, Hiba; El-Sabban, Marwan; Rezaei, Nima... more authors ... less authors ( Springer , 2023 , Book chapter)Junctional complexes play a central role in maintaining tissue hemostasis. The barrier function of epithelial cells, that maintain tissues coherence and coordination of cellular synchronicity, is a consequence of a junctional ... -
Mitoquinone supplementation alleviates oxidative stress and pathologic outcomes following repetitive mild traumatic brain injury at a chronic time point
Maha, Tabet; El-Kurdi, Marya; Haidar, Muhammad Ali; Nasrallah, Leila; Reslan, Mohammad Amine; Shear, Deborah; Pandya, Jignesh D.; El-Yazbi, Ahmed F.; Sabra, Mirna; Mondello, Stefania; Mechref, Yehia; Shaito, Abdullah; Wang, Kevin K.; El-Khoury, Riyad; Kobeissy, Firas... more authors ... less authors ( Elsevier , 2022 , Article)Traumatic brain injury (TBI) is a major cause of disability and death. Mild TBI (mTBI) constitutes ~75% of all TBI cases. Repeated exposure to mTBI (rmTBI), leads to the exacerbation of the symptoms compared to single mTBI. ... -
Nano-Engineering in Traumatic Brain Injury
Al-Thani, Najlaa; Haider, Mohammad Z.; Al-Mansoob, Maryam; Patel, Stuti; Ahmad, Salma M.S.; Kobeissy, Firas; Shaito, Abdullah... more authors ... less authors ( Wiley , 2023 , Book chapter)Traumatic brain injury (TBI) is a leading cause of mortality and chronic disability worldwide TBI involves an initial primary phase triggered by an impactful force to the brain and a subsequent secondary pathological phase. ... -
Origanum syriacum L. Attenuates the Malignant Phenotype of MDA-MB231 Breast Cancer Cells
AlKahlout, Amal; Fardoun, Manal; Mesmar, Joelle; Abdallah, Rola; Badran, Adnan; Nasser, Suzanne A.; Baydoun, Serine; Kobeissy, Firas; Shaito, Abdullah; Iratni, Rabah; Muhammad, Khalid; Baydoun, Elias; Eid, Ali H.... more authors ... less authors ( Frontiers Media , 2022 , Article)Breast cancer is the leading cause of cancer-related deaths among women. Among breast cancer types, triple negative breast cancer (TNBC) is the most aggressive, and is resistant to hormonal and chemotherapeutic treatments. ... -
Oxidative Stress-Induced Endothelial Dysfunction in Cardiovascular Diseases
Shaito, Abdullah; Aramouni, Karl; Assaf, Roland; Parenti, Astrid; Orekhov, Alexander; El Yazbi, Ahmed; Pintus, Gianfranco; Eid, Ali H.... more authors ... less authors ( IMR Press , 2022 , Article Review)Cardiovascular disease (CVD) is a major cause of mortality worldwide. A better understanding of the mechanisms underlying CVD is key for better management or prevention. Oxidative stress has been strongly implicated in the ... -
Phytochemicals as Micronutrients: What Is their Therapeutic Promise in the Management of Alzheimer’s Disease?
Reslan, Mohammad Amine; Issa, Hawraa; Al-Haj, Nadine; Ibeh, Stanley; Yehya, Yara; Hassan, Houssein Hajj; Kobeissy, Firas; Eid, Ali H.; Zibara, Kazem; Shaito, Abdullah; Mohamed, Wael; Yamashita, Toshihide... more authors ... less authors ( Springer Singapore , 2022 , Book chapter)Alzheimer’s disease (AD) is a debilitating neurodegenerative disease with devastating outcomes to patients and exhaustive burdens to healthcare systems. Alzheimer’s disease has always been the focus of extensive research ... -
Phytochemicals as Micronutrients: What Is their Therapeutic Promise in the Management of Traumatic Brain Injury?
Al-Haj, Nadine; Issa, Hawraa; El Zein, Ola; Ibeh, Stanley; Reslan, Mohammad Amine; Yehya, Yara; Kobeissy, Firas; Zibara, Kazem; Eid, Ali H.; Shaito, Abdullah; Mohamed, Wael; Yamashita, Toshihide... more authors ... less authors ( Springer Singapore , 2022 , Book chapter)Traumatic brain injury (TBI) is one of the key causes of deaths and disabilities worldwide. TBI progresses in two phases. The primary phase of injury is the direct result of the physical damage caused by the external force ...