تصفح حسب المؤلف "n 2014186546"

السجلات المعروضة 1 -- 2 من 2

    • Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale 

      Li, Xihao; Li, Zilin; Zhou, Hufeng; Gaynor, Sheila M.; Liu, Yaowu; ... more authors ( Nature Research , 2020 , Article)
      Large-scale whole-genome sequencing studies have enabled the analysis of rare variants (RVs) associated with complex phenotypes. Commonly used RV association tests have limited scope to leverage variant functions. We propose ...

    • Rare coding variants in 35 genes associate with circulating lipid levels—A multi-ancestry analysis of 170,000 exomes 

      George, Hindy; Dornbos, Peter; Chaffin, Mark D.; Liu, Dajiang J.; Wang, Minxian; ... more authors ( Elsevier , 2022 , Article)
      Large-scale gene sequencing studies for complex traits have the potential to identify causal genes with therapeutic implications. We performed gene-based association testing of blood lipid levels with rare (minor allele ...