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AuthorHumphrey, John M
AuthorAl-Absi, Enas S
AuthorHamdan, Munia M
AuthorOkasha, Sara S
AuthorAl-Trmanini, Diyna M
AuthorEl-Dous, Hend G
AuthorDargham, Soha R
AuthorSchieffelin, John
AuthorAbu-Raddad, Laith J
AuthorNasrallah, Gheyath K
Available date2019-02-06T07:37:19Z
Publication Date2019-01-31
Publication NamePLoS ONEen_US
Identifierhttp://dx.doi.org/10.1371/journal.pone.0211574
CitationHumphrey JM, Al-Absi ES, Hamdan MM, Okasha SS, Al-Trmanini DM, El-Dous HG, et al. (2019) Dengue and chikungunya seroprevalence among Qatari nationals and immigrants residing in Qatar. PLoS ONE 14(1): e0211574. https://doi.org/10.1371/journal.pone.0211574
ISSN1932-6203
URIhttp://hdl.handle.net/10576/11290
AbstractThe objective of this study is to characterize the seroprevalence of anti-dengue (DENV) and anti-chikungunya (CHIKV) antibodies among blood donors residing in Qatar who are Middle East and North Africa (MENA) nationals and non-nationals. Sera were collected from adult blood donors in Qatar from 2013 to 2016 and tested for anti-DENV and anti-CHIKV IgG using commercial microplate enzyme-linked immunosorbent assays. Age-specific seroprevalence was summarized by region/nationality: Asia (India, Philippines), Middle East (Iran, Jordan, Lebanon, Pakistan, Palestine, Syria, Yemen), North Africa (Egypt, Sudan), Qatar. The adjusted odds of anti-DENV and anti-CHIKV IgG seropositivity was estimated by logistic regression. Among 1,992 serum samples tested, Asian nationals had higher adjusted odds of being seropositive for anti-DENV antibodies compared to nationals of the Middle East (aOR 0.05, 95% CI 0.04-0.07), North Africa (aOR 0.14, 95% CI 0.10-0.20), and Qatar (aOR 0.01, 95% CI 0.01-0.03). Asian nationals also had higher adjusted odds of being seropositive for anti-CHIKV antibodies compared to those from the Middle East (aOR 0.14, 95% CI 0.07-0.27), North Africa (aOR 0.50, 95% CI 0.26-0.96), and Qatar (aOR 0.38, 95% CI 0.15-0.96). The adjusted odds of being anti-DENV seropositive was higher among anti-CHIKV seropositive adults, and vice versa (aOR 1.94, 95% CI 1.09-3.44), suggesting co-circulation of these viruses. DENV and CHIKV exposure is lower in Qatar and MENA nationals compared to Asian nationals suggesting a lower burden of DENV and CHIKV disease in the MENA. Antibodies to both viruses were detected in nationals from most MENA countries, supporting the need to better understand the regional epidemiology of these viruses.
SponsorThis work was supported by Qatar University student grants [QUST-1-CHS-2018-3/4, received by ESA, MMH, SSO, DMA, HGE] and the Qatar National Research Fund [UREP19-013-3- 001, received by LJA and GKN]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Languageen
PublisherPublic Library of Science
SubjectDengue
Subjectchikungunya
Subjectseroprevalence
SubjectQatar
TitleDengue and chikungunya seroprevalence among Qatari nationals and immigrants residing in Qatar.
TypeArticle
Pagination1-13
Issue Number1
Volume Number14


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