Biomedical Sciences
Recent Submissions
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N-Lactoyl amino acids: insights from metabolite genome-wide association studies and phenome-wide association analysis
( Oxford University Press , 2025 , Article)N-lactoyl-amino acids (Lac-AA) are emerging as important metabolites with diverse physiological roles. This study integrates metabolomics and genomics to investigate the genetic determinants and clinical relevance of three ... -
In Vitro Analysis of the Dynamic Role of the Bacterial Virulence Factors in Skin Wound Healing
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article)The skin acts as a primary barrier against environmental insults and maintains homeostasis. Injury initiates a wound healing cascade of hemostasis, inflammation, proliferation, and remodeling. In chronic wounds, persistent ... -
Deciphering the genetic diversity in the Arabian Peninsula and Africa: insights from Y-STR data
( Springer Nature , 2025 , Article)Middle Eastern and African populations make up a significant portion of the global population and exhibit substantial genetic diversity. However, genetic studies on these populations have been largely underrepresented ... -
Microsecond simulations to investigate the structural mechanism of super-resistant double mutations in BTK to the covalent inhibitor ibrutinib in multiple leukemia
( Nature Research , 2025 , Article)Bruton’s Tyrosine Kinase (BTK) is an anchor in B-cell receptor signaling and plays an important role in chronic lymphocytic leukemia (CLL). The use of covalent inhibitors of BTK, such as ibrutinib, enhances the survival ... -
Mental health of university students: a cross-sectional study from Qatar
( Nature Research , 2025 , Article)This study explored the prevalence, associated factors, and management strategies related to mental health among university students in Qatar. A cross-sectional survey was conducted among students aged 18 and older. Data ... -
Effectiveness and durability of a fourth dose of ancestral-strain mRNA vaccines against SARS-CoV-2 infection: a nationwide matched cohort study in Qatar
( Nature Research , 2025 , Article)Concerns about waning immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the emergence of new variants underscore the need for booster doses. Using a matched cohort design, this ... -
Snake venom in conjugation with silica nanoparticles: an emerging cancer therapy
( Walter de Gruyter GmbH , 2025 , Article Review)Cancer remains one of the most prevalent causes of mortality worldwide and thus necessitates the development of novel therapeutic strategies. Snake venom, consisting of a complex mixture of bioactive proteins and peptides, ... -
Selenium Nanoparticles in Cancer Therapy: Unveiling Cytotoxic Mechanisms and Therapeutic Potential
( John Wiley and Sons Inc , 2025 , Article Review)Background: Cancer represents a complex group of diseases characterized by abnormal cell proliferation, invasion, and metastasis. These features pose significant challenges to conventional therapeutic approaches, necessitating ... -
Laboratory-acquired infections in the Middle East and North Africa region: a systematic review of reported cases and biosafety gaps
( Elsevier , 2025 , Article)BackgroundLaboratory-acquired infections (LAIs) are a significant occupational health hazard to laboratory workers, who can become infected by various pathogens handled as part of their work, including bacteria, fungi, ... -
Estimating SARS-CoV-2 infection incidence and detection rates: Demonstrating a novel surveillance method
( Elsevier , 2025 , Article)ObjectivesAssessing the cumulative incidence of infection conventionally relies on documented infections or serological surveys, both of which have limitations. This study introduces a novel and practical method leveraging ... -
The microbiome-lymphoma Axis: A systematic review and Meta-analysis of gut Dysbiosis pattern in diffuse large B-cell lymphoma
( Elsevier , 2025 , Article Review)BackgroundGut microbiota has emerged as a critical mediator of immune homeostasis and cancer biology. Increasing evidence suggests that gut dysbiosis may play a significant role in the pathogenesis of diffuse large B-cell ... -
ATM inhibitors in cancer radiotherapy: Mechanisms, clinical development, and future directions
( Elsevier , 2025 , Article Review)Ataxia-telangiectasia mutated (ATM) kinase plays a pivotal role in the cellular response to DNA damage. Under normal conditions, ATM acts as a tumor suppressor by regulating pathways that lead to apoptosis and cell cycle ... -
Intranasal CD40-targeted recombinant MERS-CoV S1 protein is superior to intramuscular immunization in eliciting systemic and mucosal immune responses in mice
( Elsevier , 2026 , Article)The Middle East respiratory syndrome coronavirus (MERS-CoV) is a global One Health challenge with a potential pandemic threat, with no approved vaccines or antiviral drugs available to date. Thus, there is an urgent need ... -
ANTI-CANCEROUS POTENTIAL OF EXTRACTS OF QATARI PLANTS AGAINST A549 LUNG CANCER CELLS AND IDENTIFICATION OF THEIR BIOACTIVE COMPOUNDS UREP30-002-3-002 (BH - 250026)
( QRDI Council , 2025 , Conference)• Lung cancer is the leading cause of cancer deaths worldwide, with NSCLC accounting for most cases. • In Qatar, incidence is rising, driven by tobacco use and late-stage diagnosis. • Current therapies face major limitations, ... -
Thymol's Nanoencapsulation Reduces its Toxicity in Human Cells and Zebrafish Embryos
( Saudi Pharmacy Association (SPS)- Ministry of Health , 2025 , Conference)Thymol, a monoterpenoid and a major bioactive constituent of essential oils (EOs) derived from the plants of Lamiacea family such as Thyme, garnered wider research interest for its diverse biological activity and industrial ... -
PBA 23: Nanoencapsulation of Thymol Mitigates its Toxicity in Cells and Zebrafish Embryos
( College of Education, Qatar University , 2025 , Conference)Thymol, a monoterpenoid and a major boactive constituent of essential oils (EOs) derived from the plants of Lamiacea species such as Thyme, has garnered wider research interest for its diverse pharmaceutical, food, and ... -
Therapeutic Insights into Rubus ulmifolius Schott Leaf Extract: In Vitro Antifungal, Enzyme Inhibition, and Anticancer Activities Integrated with Network Pharmacology and Molecular Docking Analyses of Colorectal and Ovarian Cancer
( MDPI , 2025 , Article)Background/Objectives: This study evaluated the antifungal, enzyme inhibitory, and anticancer properties of the ethyl acetate (EtOAc) leaves extract of Rubus ulmifolius Schott using in vitro assays and in silico analysis. ... -
Edaravone: Advances on cytoprotective effects, pharmacological properties, and mechanisms of action
( Elsevier , 2025 , Article Review)Neurological diseases often lead to life-altering consequences, underscoring the urgent need for therapies that can reverse or mitigate their effects. Effective management of neurological disorders necessitates a thorough ... -
Nanoencapsulation mitigates the toxicity of thymol in human cells and zebrafish embryos
( Taylor and Francis Group , 2025 , Article)This study evaluated the cytotoxicity of free thymol (FT) and thymol encapsulated in monolayer (MNCT) and layer-by-layer nanocapsules (LNCT) in normal human (MCF10A, HaCaT, HdFn), and cancer cell lines (MDA-MB-231, A549, ... -
Bariatric metabolic surgery and cancer risk: Target trial emulation using iterative time distribution matching.
( The Association of Basic Medical Sciences , 2025 , Article)Bariatric metabolic surgery (BMS) is a common intervention for severe obesity, yet its effects on cancer risk remain unclear. Observational studies and meta-analyses yield inconsistent findings, while randomized controlled ...
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